Cholinergic Receptor, Nicotinic, alpha 2 (Neuronal) (CHRNA2) ELISA Kits

Gene Name	GeneID	UniProt
CHRNA2	170945	P12389
CHRNA2	110902	Q91X60
CHRNA2	1135	Q15822

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Catalog No.	Reactivity	Quantity	Supplier	Delivery	Price	Details
ABIN6200419	Human	96 Tests	Log in to see	11 to 18 Days	$589.86	Details
ABIN1144807	Mouse	96 Tests	Log in to see	15 to 18 Days	$875.60	Details
ABIN1144808	Rat	96 Tests	Log in to see	15 to 18 Days	$875.60	Details
ABIN1144806	Chicken	96 Tests	Log in to see	15 to 18 Days	$1,095.60	Details

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More ELISA Kits for CHRNA2 Interaction Partners

Human Cholinergic Receptor, Nicotinic, alpha 2 (Neuronal) (CHRNA2) interaction partners

In our analysis, we found one pair of SNPs in CHRNA1 and CHRNA7, plus one pair of SNPs in CHRNA2 and CHRNA3 reached corrected significance in tests for GxG interaction. Our study suggested evidence of interactions between CHRNs in controlling the risk of NSCL/P.
A crystal structure of a human neuronal CHRNA2 extracellular domain in pentameric assembly has been reported.
The rare variants in CHRNA2 were significantly associated with smoking status.
a heterozygous single-nucleotide substitution in CHRNA2 gene (c.1126 C>T; p. Arg376Trp) in subjects with benign familial infantile seizures
CHRNA2 mutations play a causative role in autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE).
Results show that D478E variation in nAChR alpha2 subunit increases the peak current responses of both alpha2beta2- and alpha2beta4-nAChRs; but the D478N variation in nAChR alpha2 subunit only increases the peak current responses of alpha2beta2-nAChRs
Level of cigarettes per day during adolescence and young adulthood is associated with CHRNB3A6, CHRNA5A3B4, and CHRNA2
Results indicate that the CHRNA2 signal peptide mutation T22I modulates the function of both alpha2beta2- and alpha2beta4-nAChR and decreases sensitivities to nicotine and acetylcholine, and quite possibly increasing susceptibility to nicotine dependence
findings indicate that both CHRNA2 and CHRNA6 play a significant role in the etiology of ND in AA and EA smokers
mutations of CHRNB2 and CHRNA2 genes may be rare in Chinese autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) population.
How mutations in the nAChRs can cause autosomal dominant nocturnal frontal lobe epilepsy
A new CHRNA2 mutation markedly increases the receptor sensitivity to acetylcholine, indicating that the nicotinic alpha 2 subunit alteration is the underlying cause.
From a panel of 59 single-nucleotide polymorphisms (SNPs) located on 11 candidate genes, we identify four SNPs (one each on CHRNA5 and CHRNA2 and two on CHAT) that appear to have pharmacogenetic relevance in smokin cessation therapy.
data demonstrate the rarity of the identified CHRNA2 mutations in nocturnal frontal lobe epilepsy patients, supporting the recently reported hypothesis of a restricted role for this gene in the disease
The CHRNA2 rs2043063 SNP might be a risk factor for overweight/obesity in Koreans
Results suggest that neither CHRNA4 nor CHRNB2 plays a major role in Japanese methamphetamine-use disorder.
Pleiotropic functional effects of the first epilepsy-associated mutation in the human CHRNA2 gene

CHRNA2 Antigen Profile

Antigen Summary

Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence.

Gene names and symbols associated with CHRNA2

cholinergic receptor nicotinic alpha 2 subunit (CHRNA2) antibody
cholinergic receptor, nicotinic, alpha 2a (neuronal) (chrna2a) antibody
cholinergic receptor nicotinic alpha 2 subunit (Chrna2) antibody
cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal) (Chrna2) antibody
neuronal acetylcholine receptor subunit alpha-2 (CpipJ_CPIJ002436) antibody
neuronal acetylcholine receptor subunit alpha-4-like (LOC100370261) antibody
neuronal acetylcholine receptor subunit alpha-2 (Tsp_10995) antibody

ACHR antibody
Acra-2 antibody
Acra2 antibody
BC011490 antibody
chrna2 antibody
NACHRA2 antibody
zgc:136717 antibody

Protein level used designations for CHRNA2

cholinergic receptor, nicotinic, alpha 2 (neuronal) , alpha-2 subunit, nicotinic acetylcholine receptor , cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal) , neuronal acetylcholine receptor subunit alpha-2 , cholinergic receptor, nicotinic, alpha polypeptide 2a , nicotinic acetylcholine receptor , neuronal acetylcholine receptor subunit alpha-2-like , acetylcholine receptor, nicotinic, alpha 2 (neuronal)

GENE ID	SPECIES
486101	Canis lupus familiaris
395607	Gallus gallus
712868	Macaca mulatta
678575	Danio rerio
170945	Rattus norvegicus
110902	Mus musculus
6033618	Culex quinquefasciatus
100370261	Saccoglossus kowalevskii
100403598	Callithrix jacchus
100451356	Pongo abelii
10903459	Trichinella spiralis
1135	Homo sapiens
472725	Pan troglodytes

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