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The protein encoded by CHRNA5 is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. Additionally we are shipping CHRNA5 Antibodies (71) and CHRNA5 Proteins (5) and many more products for this protein.
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The rs13180 (IREB2 (show IREB2 ELISA Kits)), rs16969968 (CHRNA5) and rs1051730 (CHRNA3 (show CHRNA3 ELISA Kits)) were significantly associated with Chronic obstructive pulmonary disease (COPD (show ARCN1 ELISA Kits)) in additive model [Padj =0.00001, odds ratio (OR)=0.64; Padj =0.0001, OR=1.41 and Padj =0.0001, OR=1.47]. The C-G haplotype by rs13180 and rs1051730 was a protective factor for COPD (show ARCN1 ELISA Kits) in our population (Padj =0.0005, OR=0.61).
Our present study suggested that rs667282 in CHRNA5-A3 may modify the prognosis of patients with advanced non-small cell lung cancer
our results show that a genomic region with functionally related genes, such as the CHRNA5/CHRNA3/CHRNB4 cluster, is under coordinated regulatory control.
The minor allele increased the risk of COPD (show ARCN1 ELISA Kits) when compared to the population at large. Homozygosity for the risk allele was associated in both cohorts with all-cause mortality, with any type of cancer among the COPD (show ARCN1 ELISA Kits) patients and with the number of pack-years among the male smokers.
The data replicate previous result suggesting CHRNA5 as a candidate gene for chronic obstructive pulmonary disease (COPD (show ARCN1 ELISA Kits)) and rs8040868 as a risk variant for the development of COPD (show ARCN1 ELISA Kits) in the Swedish population.
The results of this study suggests a pleiotropic role of Chr15q25 CHRNA5-CHRNA3-CHRNB4 gene cluster with complex influences in ADHD, tobacco smoking and cognitive performance.
Polymorphisms in the CHRNA5 and NRXN1 (show NRXN1 ELISA Kits) genes, influenced greater consumption of cigarettes in a Mexican Mestizo population.
RP11-650L12.2 rs149941240 polymorphism was associated with the risk of colorectal cancer.
We determined that the other patients harbored mutations in genes that have not previously been linked to RTT or other neurodevelopmental syndromes, such as the ankyrin repeat containing protein (show EHMT2 ELISA Kits) ANKRD31 or the neuronal acetylcholine receptor subunit alpha-5 (CHRNA5).
quitting smoking is highly beneficial in reducing lung cancer risks for smokers regardless of their CHRNA5 rs16969968 genetic risk status. Smokers with high-risk CHRNA5 genotypes, on average, can largely eliminate their elevated genetic risk for lung cancer by quitting smoking- cutting their risk of lung cancer in half and delaying its onset by 7years for those who develop it.
Chrna5 KO mice did not exhibit high responses to novelty but showed decreased novelty-induced rearing behaviour together with high anxiety. Exposure to high doses of nicotine rescued these phenotypes. Results suggest that altered alpha5*-nAChR (show CHRNA4 ELISA Kits) cholinergic signalling contributes to emotional/behavioural impairments that may be alleviated by nicotine consumption.
These results highlight the involvement of the alpha5 nAChR (show CHRNA4 ELISA Kits) subunit in the development of hyperalgesia, allodynia and inflammation associated with chronic neuropathic and inflammatory pain models.
Overexpression of the genomic cluster CHRNA5/A3/B4 in mice increases somatic signs associated with morphine withdrawal and Knockout of alpha5 gene reduced somatic signs in morphine-treated mice
Data reveal a highly regulated temporal-spatial pattern of alpha5 nAChR (show CHRNA4 ELISA Kits) subunit expression during important periods of lung morphogenesis by FoxA2 (show FOXA2 ELISA Kits).
increased nicotine intake in mice with a null mutation in Chrna5
Polymorphisms located within the Chrna5-Chrna3-Chrnb4 cluster on mouse chromosome 9 were found to co-segregate with alcohol preference, with high-drinking F(2) mice carrying B6 alleles and low-drinking F(2) mice carrying D2 alleles.
The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2).
neuronal acetylcholine receptor subunit alpha-5
, cholinergic receptor, nicotinic, alpha polypeptide 5
, Cholinergic receptor, neuronal nicotinic, alpha polypeptide-5
, acetylcholine receptor, nicotinic, alpha 5 (neuronal)
, neuronal nicotinic acetylcholine receptor, alpha5 subunit
, acetylcholine receptor alpha 5
, cholinergic receptor neuronal nicotinic alpha protein 5
, nicotinic acetylcholine receptor alpha5 subunit