Chromobox Homolog 1 Proteins (CBX1)

CBX1 encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . Additionally we are shipping Chromobox Homolog 1 Antibodies (94) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CBX1 12412 P83917
CBX1 10951 P83916
Rat CBX1 CBX1 360609  
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Top Chromobox Homolog 1 Proteins at

Showing 5 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days

CBX1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
, ,

More Proteins for Chromobox Homolog 1 (CBX1) Interaction Partners

Mouse (Murine) Chromobox Homolog 1 (CBX1) interaction partners

  1. We demonstrate an unexpected duality in the role of HP1b: it is essential in ESCs (show NR2E3 Proteins) for maintaining pluripotency, while it is required for proper differentiation in differentiated cells.

  2. The N-terminal portion of LBR (show LBR Proteins) is probably responsible for the binding to HP1b.

  3. HP1b negatively regulates MMP2 (show MMP2 Proteins) expression in a transcriptional level and prevents MMP2 (show MMP2 Proteins) activation through reducing the expression of MT1MMP (show MMP14 Proteins).

  4. Study concludes that only the 53BP1 (show TP53BP1 Proteins) status in DNA lesions, induced by UVA or gamma-rays, is affected by A-type lamin (show LMNA Proteins) deficiency, which was not observed for heterochromatin-related proteins HP1beta and BMI1 (show BMI1 Proteins).

  5. SUV39h1 (show SUV39H1 Proteins) associated with HP1 beta in fibrillarin (show FBL Proteins)-positive nucleolar regions.

  6. demonstrate that a green fluorescent protein-HP1beta fusion protein is highly mobile within both the euchromatin and heterochromatin of ex vivo resting T cells; T cell activation greatly increased this mobility

  7. HP1 (show CBX5 Proteins) isotypes have specific nonredundant functions; HP1 beta plays an essential role in the shuttling of corepressor transcriptional intermediary factor (TIF)1 (show TRIM24 Proteins) beta from eu- to heterochromatin during cell differentiation in vivo.

  8. The localization, dynamics, and mobility of HP1beta in the in mouse preimplantation embryos (pro)nucleus were examined.

  9. HP1alpha (show CBX5 Proteins) and HP1beta proteins on the heterochromatin of transcriptionally active oocytes and their absence in transcriptionally silent oocytes suggest that they are necessary for the repression of RNA synthesis in heterochromatin domains.

  10. HP1-beta is required for development of the cerebral neocortex and neuromuscular junctions

Human Chromobox Homolog 1 (CBX1) interaction partners

  1. the prolyl residue of the PXXVXL motif appears to play a role distinct from that of Pro in the known HP1beta CSD (show TGFBI Proteins)-PXVXL complexes.

  2. Data show that heterochromatin protein 1-beta (HP1beta) is a prototypic HP1 (show DEFA1 Proteins) protein exemplifying most basal chromatin binding and effects.

  3. increased HP1beta expression is associated with the poor prognosis in breast cancer

  4. In this review, we summarize the current knowledge about targeting and functional mechanisms of PRCs, emphasizing the recent breakthroughs related to CBX proteins under a number of physiological and pathological conditions.

  5. Data suggest the reduction of Heterochromatin Protein 1 isoforms HP1beta followed by a decrease in HP1alpha (show CBX5 Proteins) contributes to the pathogenesis of thyroid carcinomas, and their loss is a potential marker of thyroid malignancy and metastatic potential, respectively.

  6. Phosphorylation at Ser89 and Ser175 results in localized conformational changes in HP1beta that do not compromise the ability of the protein to bind chromatin.

  7. HP1 (show DEFA1 Proteins) isoforms distinctly augment AR signaling and cell growth in prostate cancer. Therefore, silencing of HP1beta and HP1gamma (show CBX3 Proteins) may be a promising therapeutic strategy for treatment of prostate cancer.

  8. The structural plasticity of HP1beta supports its ability to bind and connect a wide variety of binding partners in epigenetic processes.

  9. HP1beta which is associated with PCNA (show PCNA Proteins) in regions of DNA repair, is bound and does not exchange with the mobile pool, suggesting that HP1beta in association with PCNA (show PCNA Proteins) may be a component of a DNA repair complex.

  10. The HP1beta interactome is enriched with Lys (show LYZ Proteins) methylated proteins.Role of HP1beta in DNA damage response.

Chromobox Homolog 1 (CBX1) Protein Profile

Protein Summary

This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Gene names and symbols associated with Chromobox Homolog 1 Proteins (CBX1)

  • chromobox 1 (Cbx1)
  • chromobox 1 (CBX1)
  • chromobox 1 S homeolog (cbx1.S)
  • chromobox homolog 1a (HP1 beta homolog Drosophila) (cbx1a)
  • CBX protein
  • Cbx-rs2 protein
  • cbx1 protein
  • E430007M08Rik protein
  • HP1-BETA protein
  • HP1B protein
  • Hp1beta protein
  • HP1Hs-beta protein
  • HP1Hsbeta protein
  • M31 protein
  • MOD1 protein
  • p25beta protein
  • wu:fe14b09 protein
  • zgc:55739 protein

Protein level used designations for Chromobox Homolog 1 Proteins (CBX1)

HP1 beta , chromobox homolog 1 , chromobox protein homolog 1 , heterochromatin protein 1 homolog beta , heterochromatin protein p25 , modifier 1 protein , HP1 beta homolog , chromobox homolog 1 (HP1 beta homolog Drosophila ) , heterochromatin protein 1-beta , heterochromatin protein p25 beta , chromobox homolog 1 (HP1 beta homolog) , chromobox-like protein 1

12412 Mus musculus
10951 Homo sapiens
491051 Canis lupus familiaris
360609 Rattus norvegicus
444708 Xenopus laevis
374237 Gallus gallus
616506 Bos taurus
326746 Danio rerio
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