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CBX1 Products

(Chromobox Homolog 1 (CBX1))

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This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008].

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Featured CBX1 Categories

CBX1 Antibodies

High quality antibodies with extensive validation data.

CBX1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended CBX1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, FACS, ICC, IHC, WB
Validations
  • (8)
Cat. No. ABIN5542477
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human, Mouse
Application ICC, IF, IHC (p), WB
Validations
  • (5)
Cat. No. ABIN2856369
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application IF, ELISA, WB
Validations
  • (4)
Cat. No. ABIN524353
Quantity 100 μg
Datasheet Datasheet

Recommended CBX1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6211808
Quantity 96 tests
Datasheet Datasheet

Recommended CBX1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3121084
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1348201
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1348203
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our CBX1 products

Boros, Arnoult, Stroobant, Collet, Decottignies: "Polycomb repressive complex 2 and H3K27me3 cooperate with H3K9 methylation to maintain heterochromatin protein 1? at chromatin." in: Molecular and cellular biology, Vol. 34, Issue 19, pp. 3662-74, (2014) (PubMed).

Leshner, Wang, Lewis, Zheng, Chen, Santy, Wang: "PAD4 mediated histone hypercitrullination induces heterochromatin decondensation and chromatin unfolding to form neutrophil extracellular trap-like structures." in: Frontiers in immunology, Vol. 3, pp. 307, (2012) (PubMed).

Ayoub, Jeyasekharan, Bernal, Venkitaraman: "HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response." in: Nature, Vol. 453, Issue 7195, pp. 682-6, (2008) (PubMed).

Lomberk, Wallrath, Urrutia: "The Heterochromatin Protein 1 family." in: Genome biology, Vol. 7, Issue 7, pp. 228, (2007) (PubMed).

Wang, Koyama, Nishida, Haraguchi, Reith, Tsukamoto: "The assembly and maintenance of heterochromatin initiated by transgene repeats are independent of the RNA interference pathway in mammalian cells." in: Molecular and cellular biology, Vol. 26, Issue 11, pp. 4028-40, (2006) (PubMed).

Stelzl, Worm, Lalowski, Haenig, Brembeck, Goehler, Stroedicke, Zenkner, Schoenherr, Koeppen, Timm, Mintzlaff, Abraham, Bock, Kietzmann, Goedde, Toksöz, Droege, Krobitsch, Korn, Birchmeier, Lehrach et al.: "A human protein-protein interaction network: a resource for annotating the proteome. ..." in: Cell, Vol. 122, Issue 6, pp. 957-68, (2005) (PubMed).

Sharma, Hwang, Pandita, Gupta, Dhar, Parenteau, Agarwal, Worman, Wellinger, Pandita: "Human heterochromatin protein 1 isoforms HP1(Hsalpha) and HP1(Hsbeta) interfere with hTERT-telomere interactions and correlate with changes in cell growth and response to ionizing radiation." in: Molecular and cellular biology, Vol. 23, Issue 22, pp. 8363-76, (2003) (PubMed).

Kametaka, Takagi, Hayakawa, Haraguchi, Hiraoka, Yoneda: "Interaction of the chromatin compaction-inducing domain (LR domain) of Ki-67 antigen with HP1 proteins." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 7, Issue 12, pp. 1231-42, (2002) (PubMed).

Synonyms and alternative names related to CBX1

chromobox 1 (CBX1), chromobox 1 (Cbx1), chromobox homolog 1a (HP1 beta homolog Drosophila) (cbx1a), chromobox 1 S homeolog (cbx1.S), chromobox homolog 1b (HP1 beta homolog Drosophila) (cbx1b), CBX, Cbx, Cbx-rs2, cbx1, E430007M08Rik, HP1-BETA, HP1B, Hp1beta, HP1Hs-beta, HP1Hsbeta, M31, MOD1, p25beta, wu:fe14b09, zgc:55739, zgc:86924

Protein level used designations for CBX1

  • HP1 beta homolog
  • chromobox homolog 1 (HP1 beta homolog Drosophila )
  • chromobox protein homolog 1
  • heterochromatin protein 1 homolog beta
  • heterochromatin protein 1-beta
  • heterochromatin protein p25 beta
  • modifier 1 protein
  • HP1 beta
  • chromobox homolog 1
  • heterochromatin protein p25
  • chromobox homolog 1 (HP1 beta homolog)
  • chromobox-like protein 1
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