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At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. Additionally we are shipping Chromobox Homolog 3 Antibodies (145) and Chromobox Homolog 3 Kits (34) and many more products for this protein.
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HP1gamma is present in the nucleus and the cytoplasm interacting with actin, a protein complex that may exert different functions depending on its subcellular localization.
Forced expression of HP1gamma facilitated axonal and dendritic development, suggesting that the increase of HP1gamma is a rate limiting step in neuronal maturation.
in addition to histones, bacteria control host transcription by modulating the activity of HP1 (show CBX5 Proteins) proteins, with potential implications in transcriptional reprogramming at the mucosal barrier.
MeCP2 binding triggers the loss of HP1gamma at the chromosomal domain and an increased HP1gamma mobility.
Loss of heterochromatin protein 1 gamma reduces the number of primordial germ cells via impaired cell cycle progression in mice.
the role of the HP1gamma/G9a (show EHMT2 Proteins) axis is to retain centromeric regions of unpaired homologous chromosomes in close alignment and facilitate progression of their pairing in early meiotic prophase
identified 4 amino acids (165 to 168) within the chromoshadow domain of Cbx3 that are key elements for Cbx3 interaction with Dia-1 (show CYB5R3 Proteins)- and Cbx3-induced smooth muscle cell differentiation
The Ca2 (show CA2 Proteins)+ channel beta4c subunit interacts with heterochromatin protein 1 gama via a PXVXL binding motif.
Results reveal the role of HP1gamma in ESC self-renewal and in the balance between the pluripotent and the differentiation programs.
Findings demonstrate novel role for HP1gamma in transcription activation.
CBX3 has a role in promoting tumor proliferation by regulating G1/S phase via p21 (show CDKN1A Proteins) downregulation and associates with poor prognosis in tongue squamous cell carcinoma
The deletion of CBX3 directly enforces the expression of CDK6 (show CDK6 Proteins) and p21 (show CDKN1A Proteins).
These data indicate that HP1-gamma is a novel epigenetic repressor of epsilon-globin (show HBe1 Proteins) gene expression.
these data underscore the importance of IDRs 1, 2, and 3 in defining the structural and dynamic properties of HP1gamma, discoveries that have both mechanistic and potentially biomedical relevance.
In contrast to HP1alpha (show CBX5 Proteins), HP1gamma could not recognize H3K9me3 in extended nucleosomes.
this study identified miR (show MLXIP Proteins)-30a as a tumor-suppressive microRNA that targets HP1gamma in vitro and in vivo to specifically suppress the growth of colorectal cancer in mouse xenograft models.
BARD1 (show BARD1 Proteins) interacts with H3K9me2 through HP1 (show DEFA1 Proteins) and plays a critical role in retention of a BRCA1/BARD1 (show BARD1 Proteins) complex at the site of DNA damage.
CBX3 and CRABP2 (show CRABP2 Proteins) expression was markedly increased in lung cancer tissues
our data suggested that HP1gamma plays an important role in promoting non-small cell lung cancer
Dynamic changes of the nuclear-cytoplasmic and subnuclear distribution of members of the Cbx (show CBX1 Proteins) family may be central to the maternal to embryonic transition.
At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.
, chromobox homolog 3
, chromobox protein homolog 3
, heterochromatin protein 1 gamma
, heterochromatin protein 1 homolog gamma
, modifier 2 protein
, HP1 gamma homolog
, chromobox homolog 3 (HP1 gamma homolog, Drosophila)
, heterochromatin protein HP1 gamma
, heterochromatin-like protein 1
, chromobox homolog 3 a
, chromobox protein (CHCB2)
, chromobox-like protein 3