Chromobox Homolog 3 Proteins (CBX3)

At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. Additionally we are shipping Chromobox Homolog 3 Antibodies (193) and Chromobox Homolog 3 Kits (39) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CBX3 11335 Q13185
Rat CBX3 CBX3 297093  
CBX3 12417  
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Top Chromobox Homolog 3 Proteins at

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 to 35 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
Wheat germ Human GST tag 10 μg 11 to 12 Days
Escherichia coli (E. coli) Human His tag 100 μg 15 to 19 Days
Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg 11 Days
Escherichia coli (E. coli) Human Un-conjugated SDS-PAGE analysis of Human Chromobox Homolog 3 Protein. 100 μg 11 to 18 Days
Escherichia coli (E. coli) Mouse Un-conjugated SDS-PAGE analysis of Mouse Chromobox Homolog 3 Protein. 100 μg 11 to 18 Days
Yeast Orang-Utan His tag   1 mg 60 to 71 Days
Yeast Human Un-conjugated   100 μg 11 to 16 Days

CBX3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

More Proteins for Chromobox Homolog 3 (CBX3) Interaction Partners

Human Chromobox Homolog 3 (CBX3) interaction partners

  1. Direct epigenetic repression of the transcription-repressive regulators NCOR2 and ZBTB7A by the histone reader protein HP1gamma leads to activation of protumorigenic genes in lung adenocarcinoma.

  2. CBX3 is of great significance in the prognosis and progression of human osteosarcoma. CBX3 is highly expressed in human osteosarcoma tissues. The dismal prognosis of patients suffering from osteosarcoma can be predicted by high CBX3 expression.

  3. We report a significant upregulation of CBX3/HP1-gamma in non-small cell lung cancer patients

  4. c-Myc was capable of upregulating HP1gamma by directly binding to the E-box element in the first intron of HP1gamma gene, and the upregulated HP1gamma, in turn, repressed the expression of miR-451a by enhancing H3K9 methylation at the promoter region of miR-451a.

  5. CBX3 was overexpressed in pancreatic adenocarcinoma, which was associated with poor prognosis. CDK1 knockdown attenuated the cell cycle transition, proliferation and invasion of CBX3-overexpressing PAAD cells.

  6. CBX3 serves as a positive regulator of aerobic glycolysis via suppressing of the FBP1 in pancreatic cancer cells.

  7. HP1gamma is present in the nucleus and the cytoplasm interacting with actin, a protein complex that may exert different functions depending on its subcellular localization.

  8. CBX3 has a role in promoting tumor proliferation by regulating G1/S phase via p21 downregulation and associates with poor prognosis in tongue squamous cell carcinoma

  9. The deletion of CBX3 directly enforces the expression of CDK6 and p21.

  10. These data indicate that HP1-gamma is a novel epigenetic repressor of epsilon-globin gene expression.

  11. these data underscore the importance of IDRs 1, 2, and 3 in defining the structural and dynamic properties of HP1gamma, discoveries that have both mechanistic and potentially biomedical relevance.

  12. In contrast to HP1alpha, HP1gamma could not recognize H3K9me3 in extended nucleosomes.

  13. this study identified miR-30a as a tumor-suppressive microRNA that targets HP1gamma in vitro and in vivo to specifically suppress the growth of colorectal cancer in mouse xenograft models.

  14. BARD1 interacts with H3K9me2 through HP1 and plays a critical role in retention of a BRCA1/BARD1 complex at the site of DNA damage.

  15. CBX3 and CRABP2 expression was markedly increased in lung cancer tissues

  16. our data suggested that HP1gamma plays an important role in promoting non-small cell lung cancer

  17. compartmentalized and total HP1gamma protein expression is increased in PCa and that expression correlates with clinical outcomes better than Gleason score.

  18. HP1gamma affects the spontaneous differentiation potential of P19 cells, and might play major roles in the decision of cell fates in pluripotent stem cells.

  19. study finds that while HP1apha and beta stimulate homologous recombination and single-strand annealing, HP1gamma has an inhibitory role

  20. Identification of CBX3 and ABCA5 as putative biomarkers for tumor stem cells in osteosarcoma.

Cow (Bovine) Chromobox Homolog 3 (CBX3) interaction partners

  1. Dynamic changes of the nuclear-cytoplasmic and subnuclear distribution of members of the Cbx family may be central to the maternal to embryonic transition.

Mouse (Murine) Chromobox Homolog 3 (CBX3) interaction partners

  1. Cbx3 modulates vascular smooth muscle cells contractile and collagen gene expression, as well as VSMC proliferation, migration, and apoptosis via a Notch3 pathway, and plays an important role in controlling injury-induced neointima formation.

  2. Citrullination of HP1gamma is dynamically regulated during mESC differentiation. The citrullinated residues lie within the HP1gamma chromodomain and are important for H3K9me3 binding.

  3. Data indicate that HP1gamma is dispensable for cell cycle exit and normal cardiac growth but has a significant role in maintaining H4K20me3 and regulating a limited number of genes in cardiac myocytes.

  4. HP1gamma is present in the nucleus and the cytoplasm interacting with actin, a protein complex that may exert different functions depending on its subcellular localization.

  5. it is the small size of the Cbx3hypo/hypo neonates, a likely consequence of placental growth and transport defects, combined with a possible inability to thermoregulate that causes the severe postnatal mortality.

  6. Forced expression of HP1gamma facilitated axonal and dendritic development, suggesting that the increase of HP1gamma is a rate limiting step in neuronal maturation.

  7. in addition to histones, bacteria control host transcription by modulating the activity of HP1 proteins, with potential implications in transcriptional reprogramming at the mucosal barrier.

  8. MeCP2 binding triggers the loss of HP1gamma at the chromosomal domain and an increased HP1gamma mobility.

  9. Loss of heterochromatin protein 1 gamma reduces the number of primordial germ cells via impaired cell cycle progression in mice.

  10. the role of the HP1gamma/G9a axis is to retain centromeric regions of unpaired homologous chromosomes in close alignment and facilitate progression of their pairing in early meiotic prophase

  11. identified 4 amino acids (165 to 168) within the chromoshadow domain of Cbx3 that are key elements for Cbx3 interaction with Dia-1- and Cbx3-induced smooth muscle cell differentiation

  12. The Ca2+ channel beta4c subunit interacts with heterochromatin protein 1 gama via a PXVXL binding motif.

  13. Results reveal the role of HP1gamma in ESC self-renewal and in the balance between the pluripotent and the differentiation programs.

  14. 5'-upstream region consists of a multiple regulatory complex which plays important roles in nuclear function such as chromatin organization and RNA processing

  15. Findings demonstrate novel role for HP1gamma in transcription activation.

  16. Pax3 represses transcription through a novel mechanism involving competition between corepressor KAP1 and the heterochromatin-binding protein HP1gamma

Chromobox Homolog 3 (CBX3) Protein Profile

Protein Summary

At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.

Gene names and symbols associated with Chromobox Homolog 3 Proteins (CBX3)

  • chromobox 3 (CBX3)
  • chromobox 3 (Cbx3)
  • chromobox 3 L homeolog (cbx3.L)
  • chromobox protein homolog 3 pseudogene (LOC100355282)
  • chromobox homolog 3a (HP1 gamma homolog, Drosophila) (cbx3a)
  • cbx3 protein
  • cbx3a protein
  • HECH protein
  • Hp1-gamma protein
  • HP1g protein
  • HP1Hs-gamma protein
  • M32 protein
  • wu:fb61b02 protein
  • xhp1g protein
  • zgc:153397 protein

Protein level used designations for Chromobox Homolog 3 Proteins (CBX3)

HP1 gamma homolog , chromobox homolog 3 (HP1 gamma homolog, Drosophila) , chromobox protein homolog 3 , heterochromatin protein 1 homolog gamma , heterochromatin protein HP1 gamma , heterochromatin-like protein 1 , modifier 2 protein , HP1 gamma , heterochromatin protein 1 gamma , chromobox-like protein 3 , chromobox homolog 3 , chromobox homolog 3 a , chromobox protein (CHCB2)

11335 Homo sapiens
297093 Rattus norvegicus
539788 Bos taurus
12417 Mus musculus
399208 Xenopus laevis
395355 Gallus gallus
482015 Canis lupus familiaris
100173451 Pongo abelii
100355282 Oryctolagus cuniculus
100714020 Cavia porcellus
101106931 Ovis aries
751689 Danio rerio
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