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CBX3 Products

(Chromobox Homolog 3 (CBX3))
At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.[provided by RefSeq, Mar 2011].

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Featured CBX3 Categories

CBX3 Antibodies

High quality antibodies with extensive validation data.

CBX3 ELISA Kits

Reliable ELISA kits for a wide range of species.

CBX3 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended CBX3 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, FACS, ICC, IHC, WB
Validations
  • (6)
Cat. No. ABIN5542474
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IF, IHC, WB
Validations
  • (6)
Cat. No. ABIN7260333
Quantity 200 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, IHC, WB
Validations
  • (6)
Cat. No. ABIN5693033
Quantity 100 μg
Datasheet Datasheet

Recommended CBX3 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6965808
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6965807
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6954774
Quantity 96 tests
Datasheet Datasheet

Recommended CBX3 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
Cat. No. ABIN1348210
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3133349
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3090507
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our CBX3 products

Boros, Arnoult, Stroobant, Collet, Decottignies: "Polycomb repressive complex 2 and H3K27me3 cooperate with H3K9 methylation to maintain heterochromatin protein 1? at chromatin." in: Molecular and cellular biology, Vol. 34, Issue 19, pp. 3662-74, (2014) (PubMed).

Yan, Xing, Guo, Fang, Jiao, Guo, Xu, Fang, Holmberg, Nilsson, Liu: "Somatostatin derivative (smsDX) targets cellular metabolism in prostate cancer cells after androgen deprivation therapy." in: PLoS ONE, Vol. 8, Issue 2, pp. e55790, (2013) (PubMed).

Di Cello, Shin, Harbom, Brayton: "Knockdown of HMGA1 inhibits human breast cancer cell growth and metastasis in immunodeficient mice." in: Biochemical and biophysical research communications, Vol. 434, Issue 1, pp. 70-4, (2013) (PubMed).

Lin, Cheng, Yang, Lin, Wang, Lai, Shieh: "Loss of the candidate tumor suppressor BTG3 triggers acute cellular senescence via the ERK-JMJD3-p16(INK4a) signaling axis." in: Oncogene, Vol. 31, Issue 27, pp. 3287-97, (2012) (PubMed).

Thorne, Ouboussad, Lefevre: "Heterochromatin protein 1 gamma and I?B kinase alpha interdependence during tumour necrosis factor gene transcription elongation in activated macrophages." in: Nucleic acids research, Vol. 40, Issue 16, pp. 7676-89, (2012) (PubMed).

Lomberk, Wallrath, Urrutia: "The Heterochromatin Protein 1 family." in: Genome biology, Vol. 7, Issue 7, pp. 228, (2007) (PubMed).

Wang, Koyama, Nishida, Haraguchi, Reith, Tsukamoto: "The assembly and maintenance of heterochromatin initiated by transgene repeats are independent of the RNA interference pathway in mammalian cells." in: Molecular and cellular biology, Vol. 26, Issue 11, pp. 4028-40, (2006) (PubMed).

Vakoc, Mandat, Olenchock, Blobel: "Histone H3 lysine 9 methylation and HP1gamma are associated with transcription elongation through mammalian chromatin." in: Molecular cell, Vol. 19, Issue 3, pp. 381-91, (2005) (PubMed).

Kametaka, Takagi, Hayakawa, Haraguchi, Hiraoka, Yoneda: "Interaction of the chromatin compaction-inducing domain (LR domain) of Ki-67 antigen with HP1 proteins." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 7, Issue 12, pp. 1231-42, (2002) (PubMed).

Nielsen, Ortiz, You, Oulad-Abdelghani, Khechumian, Gansmuller, Chambon, Losson: "Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family." in: The EMBO journal, Vol. 18, Issue 22, pp. 6385-95, (2000) (PubMed).

Synonyms and alternative names related to CBX3

chromobox 3 (CBX3), chromobox 3 (Cbx3), chromobox 3 L homeolog (cbx3.L), chromobox protein homolog 3 pseudogene (LOC100355282), chromobox homolog 3a (HP1 gamma homolog, Drosophila) (cbx3a), cbx3, cbx3a, HECH, HP1-GAMMA, Hp1-gamma, HP1g, HP1Hs-gamma, M32, wu:fb61b02, xhp1g, zgc:153397

Protein level used designations for CBX3

  • HP1 gamma homolog
  • chromobox homolog 3 (HP1 gamma homolog, Drosophila)
  • chromobox protein homolog 3
  • heterochromatin protein 1 homolog gamma
  • heterochromatin protein HP1 gamma
  • heterochromatin-like protein 1
  • modifier 2 protein
  • HP1 gamma
  • heterochromatin protein 1 gamma
  • chromobox-like protein 3
  • chromobox homolog 3
  • chromobox homolog 3 a
  • chromobox protein (CHCB2)
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