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E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I.
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The Cbx4 plays a crucial role in the p63-regulated program of epidermal differentiation, maintaining the epithelial identity and proliferative activity in KCs via repression of the selected nonepidermal lineage and cell cycle inhibitor genes.
Data indicate an important role of chromobox homolog 4 protein CBX4 in production of high quality oocytes.
Cbx4 is a crucial regulator for the generation and maintenance of the thymic epithelium and, hence, for thymocyte development.
SUMO interaction motif 2 (SIM2 (show SIM2 Proteins)) is crucial for many of the documented Pc2 functions, which converge on determining its E3 ligase activity.
Our results suggest that Cbx4 functions as a SUMO E3 ligase for Dnmt3a and it might be involved in the functional regulation of DNA methyltransferases by promoting their SUMO modification.
Data show that USP26 interacts with PRC1 (show PRC1 Proteins) components chromobox (CBX (show CBX1 Proteins))-containing proteins CBX4 and CBX6 (show CBX6 Proteins).
Data show that SUMO E3 ligase (show PIAS1 Proteins) CBX4 sumoylates subpopulation of CtIP (show RBBP8 Proteins) to regulate recruitment to breaks and resection.
provide evidence to show that CBX4 may serve as a tumor suppressor in colorectal carcinoma by recruiting HDAC3 (show HDAC3 Proteins) to the Runx2 (show RUNX2 Proteins) promoter to impede Runx2 (show RUNX2 Proteins) expression
Cbx4 is an independent prognostic factor for HCC (show FAM126A Proteins) patients, and the patients with high Cbx4 expression should receive postoperative TACE (show ADAM17 Proteins) treatment to improve their survival
our study demonstrated that miR (show MLXIP Proteins)-195 acts as a tumor suppressor by directly targeting CBX4 in hepatocellular carcinoma
Role of Cbx4 in migration and metastasis of a metastatic hepatocellular carcinoma cell line. Results show that Cbx4 overexpression increases the in vitro vessel formation of vascular endothelial cells in its SUMO interaction motifs-dependent manner.
The presence of CBX4-GFP in the same focus had a minor impact on BMI1 and RING1 recovery kinetics.
High cytoplasmic expression of CBX4 is associated with hepatocellular carcinoma.
our findings demonstrate that Cbx4 plays a critical role in tumor angiogenesis by governing HIF-1alpha (show HIF1A Proteins) protein
ASXL1 (show ASXL1 Proteins) associates with the PRC2 and loss of ASXL1 (show ASXL1 Proteins) in vivo collaborates with NRASG12D to promote myeloid leukemogenesis.
E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones\; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
chromobox homolog 4
, E3 SUMO-protein ligase CBX4
, chromobox protein homolog 4
, polycomb 2 homolog
, NS5ATP1-binding protein 16
, Pc class 2 homolog
, chromobox homolog 4 (Pc class homolog, Drosophila)
, chromobox homolog 4 (Pc class homolog)
, chromobox homolog 4 (Polycomb)
, chromobox protein (CHCB3)
, chromobox-like protein 4
, polycomb 2