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CBX4 Products

(Chromobox Homolog 4 (CBX4))

Categories

E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones\; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

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Featured CBX4 Categories

CBX4 Antibodies

High quality antibodies with extensive validation data.

CBX4 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended CBX4 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, IF, IHC
Validations
  • (3)
Cat. No. ABIN7150950
Quantity 100 μg
Datasheet Datasheet
Reactivity Cow, Dog, Guinea Pig, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application IHC, WB
Validations
  • (1)
  • (2)
Cat. No. ABIN2779230
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7150954
Quantity 100 μL
Datasheet Datasheet

Recommended CBX4 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6209563
Quantity 96 tests
Datasheet Datasheet

Recommended CBX4 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3131894
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3091174
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1348212
Quantity 2 μg
Datasheet Datasheet

Latest Publications for our CBX4 products

Han, Wang, Li, Dong, Zhang, Yan: "HIF-1α SUMOylation affects the stability and transcriptional activity of HIF-1α in human lens epithelial cells." in: Graefe's archive for clinical and experimental ophthalmology, Vol. 253, Issue 8, pp. 1279-90, (2015) (PubMed).

Peuget, Bonacci, Soubeyran, Iovanna, Dusetti: "Oxidative stress-induced p53 activity is enhanced by a redox-sensitive TP53INP1 SUMOylation." in: Cell death and differentiation, Vol. 21, Issue 7, pp. 1107-18, (2014) (PubMed).

Hao, Midic, Garriga, Latham: "Contribution of CBX4 to cumulus oophorus cell phenotype in mice and attendant effects in cumulus cell cloned embryos." in: Physiological genomics, Vol. 46, Issue 2, pp. 66-80, (2014) (PubMed).

Ismail, Gagné, Caron, McDonald, Xu, Masson, Poirier, Hendzel: "CBX4-mediated SUMO modification regulates BMI1 recruitment at sites of DNA damage." in: Nucleic acids research, Vol. 40, Issue 12, pp. 5497-510, (2012) (PubMed).

Oh, Kim, Mouradian, Chung: "Human Polycomb protein 2 promotes ?-synuclein aggregate formation through covalent SUMOylation." in: Brain research, Vol. 1381, pp. 78-89, (2011) (PubMed).

Yang, Sharrocks: "The SUMO E3 ligase activity of Pc2 is coordinated through a SUMO interaction motif." in: Molecular and cellular biology, Vol. 30, Issue 9, pp. 2193-205, (2010) (PubMed).

Vincenz, Kerppola: "Different polycomb group CBX family proteins associate with distinct regions of chromatin using nonhomologous protein sequences." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 43, pp. 16572-7, (2008) (PubMed).

Jones, Fusi, Higham, Abdel-Hafiz, Horwitz, Lam, Brosens: "Regulation of the SUMO pathway sensitizes differentiating human endometrial stromal cells to progesterone." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 44, pp. 16272-7, (2006) (PubMed).

Kagey, Melhuish, Wotton: "The polycomb protein Pc2 is a SUMO E3." in: Cell, Vol. 113, Issue 1, pp. 127-37, (2003) (PubMed).

Synonyms and alternative names related to CBX4

chromobox 4 (CBX4), chromobox 4 (Cbx4), chromobox 4 S homeolog (cbx4.S), chromobox homolog 4 (CBX4), chromobox homolog 4 (Pc class homolog, Drosophila) (cbx4), cbx4-a, im:6911625, MPc2, NBP16, PC2, XPolycomb, zgc:158588

Protein level used designations for CBX4

  • chromobox homolog 4
  • E3 SUMO-protein ligase CBX4
  • chromobox protein homolog 4
  • polycomb 2 homolog
  • NS5ATP1-binding protein 16
  • Pc class 2 homolog
  • chromobox homolog 4 (Pc class homolog, Drosophila)
  • chromobox homolog 4 (Pc class homolog)
  • chromobox homolog 4 (Polycomb)
  • chromobox protein (CHCB3)
  • chromobox-like protein 4
  • polycomb 2
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