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The product of CHD4 belongs to the SNF2/RAD54 helicase family. Additionally we are shipping CHD4 Antibodies (90) and CHD4 Proteins (7) and many more products for this protein.
Showing 2 out of 7 products:
that CHD4 is not only a potential prognostic biomarker for triple-negative breast cancer (TNBC) patient survival, but is also a powerful candidate in the development of new anti-cancer agents in TNBC
the N-terminal part of CHD4 interacts with an unstructured A-rich region in promoter and pre-rRNA antisense "), a long noncoding RNA that is transcribed in an orientation antisense to pre-rRNA
RNA interference identifies CHD4 as an essential gene in regulating breast cancer growth.
Data suggest TCF19 interacts with histone 3 lysine 4 trimethylation through its plant homeodomain finger; TCF19 expression appears to regulate gluconeogenesis in hepatocytes; TCF19 interacts with CHD4 causing NuRD complex recruitment to gene promoters of enzymes involved in gluconeogenesis. (TCF19 = transcription factor 19; CHD4 = chromodomain helicase DNA binding protein 4; NuRD = nucleosome-remodeling-deacetylase)
CHD3 (show CHD3 ELISA Kits) and CHD4 exhibit distinct nuclear localization patterns in unperturbed cells, revealing a subset of specific target genes.
The findings identify that CHD4 deficiency preferentially impairs cell survival via increasing the level of p21 (show CDKN1A ELISA Kits).
Mutation in CHD4 gene is associated with congenital heart defects.
this work identifies CHD4 as an epigenetic coregulator of PAX3 (show PAX3 ELISA Kits)-FOXO1 (show FOXO1 ELISA Kits) activity, providing rational evidence for CHD4 as a potential therapeutic target in alveolar rhabdomyosarcoma.
CHD4 recruits repressive chromatin proteins to sites of DNA damage repair, including DNA methyltransferases where it imposes de novo DNA methylation. At TSGs, CHD4 retention helps maintain DNA hypermethylation-associated transcriptional silencing.
this study identifies the Chd4-Tbx3 (show TBX3 ELISA Kits) axis in controlling ESC fate and a role of H2A.Z (show H2AFZ ELISA Kits) in maintaining the stability of Chd4 proteins.
Direct CHD4-mediated repression of skeletal and smooth muscle myofibril isoforms is required for normal cardiac sarcomere formation, function, and embryonic survival early in gestation. Unique CHD4 binding sites are found in smooth muscle myosin heavy chain, fast skeletal alpha-actin, and the fast skeletal troponin complex genes.
Chd4 mutant embryos died before birth and exhibited severe edema, blood-filled lymphatics, and liver hemorrhage. CHD4-deficient embryos developed normal lymphovenous (LV) valves, which regulate the return of lymph to the blood circulation; however, these valves lacked the fibrin-rich thrombi that prevent blood from entering the lymphatic system.
This secreted effector, toxoplasma inhibitor of STAT1 (show STAT1 ELISA Kits)-dependent transcription (TgIST), translocates to the host cell nucleus, where it recruits mouse Mi-2/NuRD to STAT1 (show STAT1 ELISA Kits)-dependent promoters, resulting in altered chromatin and blocked transcription.
this study shows that the chromatin remodeler Mi-2beta controls epidermal homeostasis by regulating the genes involved in keratinocyte and immune-cell activation to maintain an inactive state
preservation of the identity of the two striated (show NSDHL ELISA Kits) muscle types depends on epigenetic repression of the alternate lineage gene program by the chromatin remodeling complex Chd4/NuRD.
complex lacking CHD4 that has HDAC (show HDAC3 ELISA Kits) activity can exist as a stable species. The addition of recombinant CHD4 to this nucleosome deacetylase complex reconstitutes a NuRD complex with nucleosome remodeling activity.
CHD4 depletion modulates expression of acute myeloid leukemia (show BCL11A ELISA Kits) cell genes that regulate tumor formation in vivo and colony formation in vitro.
CHD4 allows cells to undertake lineage commitment in vivo by modulating the frequency with which lineage-specification genes are expressed.
Chromatin immunoprecipitation assays showed that CHD4-containing NuRD complexes directly bound the promoters of these genes in endothelial cells
CHD4 functions as a MAP required for MT stabilization and is involved in generating spindle bipolarity.
The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein.
chromodomain helicase DNA binding protein 4
, chromodomain-helicase-DNA-binding protein 4
, ATP-dependent helicase CHD4
, Mi-2 autoantigen 218 kDa protein
, Mi-2 autoantigen
, Mi-2 beta