Chromosome 13 Open Reading Frame 15 Proteins (C13orf15)

C13orf15 is thought to regulate cell cycle progression. Additionally we are shipping Chromosome 13 Open Reading Frame 15 Antibodies (20) and Chromosome 13 Open Reading Frame 15 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
C13orf15 28984 Q9H4X1
C13orf15 66214 Q9DBX1
Rat C13orf15 C13orf15 117183 Q9Z2P4
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Top Chromosome 13 Open Reading Frame 15 Proteins at antibodies-online.com

Showing 4 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,370.21
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,370.21
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 11 Days
$547.80
Details

C13orf15 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Chromosome 13 Open Reading Frame 15 (C13orf15) Interaction Partners

Human Chromosome 13 Open Reading Frame 15 (C13orf15) interaction partners

  1. RGC32 facilitates epithelial-mesenchymal transition of colorectal cancer cells by activating Smad/Sip1 signaling.

  2. This study demonstrated the up-regulation of RGC-32 contributed to the imbalance of Treg/Th17 cells in patients with Dilated Cardiomyopathy. [RGC-32]

  3. RGC-32 mediates human aortic endothelial cell migration through the regulation of RhoA and ROCK1 expression.

  4. RGCC may be a candidate cell cycle target for neuroprotection during the onset of Alzheimer's disease.

  5. RGC-32 expression on M2-polarized and tumor-associated macrophages is M-CSF-dependent and enhanced by tumor-derived IL-4.

  6. Data suggest that expression of RGC32 is down-regulated in placental trophoblasts in women with pre-eclampsia as compared to women with normal term pregnancies; silencing RGC32 expression by RNA interference inhibits trophoblast migration/invasion.

  7. Suggest that RGC32 is involved in tumorigenesis of human lung cancer, inducing apoptosis and inhibiting cell growth, migration, and invasion.

  8. In conclusion, the present study indicates that C5a may promote the proliferation of breast cancer cells through Akt1 activation of the RGC-32 gene.

  9. results demonstrate for the first time that RGC-32 is a novel membrane regulator for macrophage phagocytosis.

  10. RGC32 promotes cell migration and invasion and induces epithelial-mesenchymal transition in lung cancer cells via the NF-kappaB signaling pathway.

  11. data suggest RGC-32 plays a dual role in multiple sclerosis, both as a regulator of T-cells mediated apoptosis and as a promoter of TGF-beta-mediated profibrotic effects in astrocytes

  12. analysis of upregulation of the cell-cycle regulator RGC-32 in Epstein-Barr virus-immortalized cells, due to transcriptional activation by high levels of the differentially expressed RUNX1c transcription factor

  13. Data demonstrate that RGC-32 interacts with Smad3 to mediate the epithelial-mesenchymal transition of human renal proximal tubular cells.

  14. methylation-associated down-regulation of RGC32 plays an important role in the pathogenesis of NSCLC, particularly in females

  15. RGC-32 may contribute to the development of colon cancer by regulating chromatin assembly.

  16. RGC-32 overexpression might be part of the deregulation of the cell cycle that is required for the growth of tumor cells

  17. Endogenous p53 protein binds to the promoter region of the RGC32 gene, implying p53-dependent transcriptional activity.

  18. Spacial/temporal-specific expression of Rgc32 in the ovary and expression in granulosa cells.

  19. RGC-32 plays a critical role in TGF-beta-induced epithelial-mesenchymal transition of renal tubular cells

  20. Cell cycle induction by C5b-9 in aortic endothelial cells is RGC-32 dependent and this is in part through regulation of Akt and growth factor release.

Mouse (Murine) Chromosome 13 Open Reading Frame 15 (C13orf15) interaction partners

  1. RGC-32 mediates atherogenesis by facilitating monocyte-endothelial cell interaction via the induction of endothelial ICAM-1 and VCAM-1 expression, at least partially, through NF-kappaB signaling pathway.

  2. results identify RGC-32 as a novel regulator of Th17 cell differentiation in vitro and in vivo and suggest that RGC-32 is a potential therapeutic target in multiple sclerosis and other Th17-mediated autoimmune diseases

  3. results demonstrate that RGC-32 contributes to the development of hepatic steatosis by facilitating de novo lipogenesis through activating liver X receptor, leading to the induction of SREBP-1c and its target genes

  4. RGC-32 is involved in controlling the cell cycle of T cells in vivo, and this effect is mediated by IL-2 in a PI3K-dependent fashion.

  5. RGC32 plays an important role in diet-induced obesity and insulin resistance, and thus it may serve as a potential novel drug target for developing therapeutics to treat obesity and metabolic disorders.

  6. results demonstrate for the first time that RGC-32 is a novel membrane regulator for macrophage phagocytosis.

  7. knockdown of RGC-32 by shRNA inhibited VEGF-induced endothelial cell proliferation, migration, and tube formation while blocking VEGFR2 expression.

  8. RGC-32 as a novel fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation.

  9. Smad2 and PEA3 regulate RGC-32 transcription which is essential for smooth muscle cell differentiation from neural crest cells.

Chromosome 13 Open Reading Frame 15 (C13orf15) Protein Profile

Protein Summary

This gene is thought to regulate cell cycle progression. It is induced by p53 in response to DNA damage, or by sublytic levels of complement system proteins that result in activation of the cell cycle. The encoded protein localizes to the cytoplasm during interphase and to centrosomes during mitosis. The protein forms a complex with polo-like kinase 1. The protein also translocates to the nucleus in response to treatment with complement system proteins, and can associate with and increase the kinase activity of cell division cycle 2 protein. In different assays and cell types, overexpression of this protein has been shown to activate or suppress cell cycle progression.

Gene names and symbols associated with C13orf15

  • regulator of cell cycle (RGCC)
  • regulator of cell cycle (Rgcc)
  • regulator of cell cycle (rgcc)
  • 1190002H23Rik protein
  • bA157L14.2 protein
  • C12H13orf15 protein
  • C13orf15 protein
  • Rgc-32 protein
  • Rgc32 protein
  • sb:cb658 protein
  • wu:fa94a05 protein
  • zgc:91870 protein

Protein level used designations for C13orf15

regulator of cell cycle RGCC , response gene to complement 32 protein , RGC-32

GENE ID SPECIES
28984 Homo sapiens
66214 Mus musculus
117183 Rattus norvegicus
100625944 Sus scrofa
614348 Bos taurus
431737 Danio rerio
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