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Probable hormone that may induce senescence of oligodendrocyte and neural precursor cells, characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation.. Additionally we are shipping Chromosome 2 Open Reading Frame 40 Kits (6) and Chromosome 2 Open Reading Frame 40 Proteins (6) and many more products for this protein.
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Human Polyclonal C2orf40 Primary Antibody for IHC, IHC (p) - ABIN4306960
Baird, Coimbra, Dang, Lopez, Lee, Krzyzaniak, Winfield, Potenza, Eliceiri: Cell surface localization and release of the candidate tumor suppressor Ecrg4 from polymorphonuclear cells and monocytes activate macrophages. in Journal of leukocyte biology 2012
Show all 2 Pubmed References
mutations in Pakistani patients with dilated cardiomyopathy rs375563861 (C2orf40), rs143187236 (MYOM3), and rs564181443 (RTKN2 (show RTKN2 Antibodies)) have 3 fold or higher allele frequency in South Asians than in the global populations
ECRG4 down-regulates UBE2C (show UBE2C Antibodies) expression in esophageal squamous cell carcinoma cells.
Results from many studies support the discovery that ECRG4 plays a critical role in the pathogenesis of atrial fibrillation. [review]
UBR5 (show UBR5 Antibodies) directly binds to the tumor suppressor esophageal cancer-related gene 4, increasing its ubiquitination to reducing the protein stability of ECRG4 to promote colorectal cancer progression.
positive and negative regulatory elements controlling ECRG4 expression include a counter regulation between promoter methylation and Sp1 (show PSG1 Antibodies) activation.
the overexpression of Beclin 1 (show BECN1 Antibodies) promoted apoptosis and decreased invasion by upregulating the expression of ECRG4 in A549 lung adenocarcinoma cells. Therefore, the selection of Beclin l as a target for gene therapy represents a more effective method for the treatment of lung cancer.
Downregulated ECRG4 is correlated with lymph node metastasis in nasopharyngeal carcinoma
The overexpression of ECRG4 inhibited tumorigenesis.
ECRG4 may be a tumor suppressor in renal cancer and serve as a prognostic marker
low expression or no expression of ECRG4 in esophageal cancer tissues was closely related to the degree of tumor invasion level, TNM (show ODZ1 Antibodies) staging, lymph node metastasis and recurrence and survival after surgery.
proteolytic cleavage by furin (show FURIN Antibodies) is a posttranslational requirement for proaugurin to suppress cell proliferation
identified esophageal cancer-related gene 4 (Ecrg4) as a senescence inducer with implications for the senescence-like state of postmitotic cells in the aging brain.
ECRG4 level in differentiated chondrocytes is decreased during hypertrophic maturation
Probable hormone that may induce senescence of oligodendrocyte and neural precursor cells, characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation.
esophageal cancer related gene 4 protein
, esophageal cancer-related gene 4 protein
, UPF0689 protein C2orf40 homolog
, esophageal cancer-related gene 4 protein homolog