C2orf40 antibody

Catalog No. ABIN1387821

Product Details anti-C2orf40 Antibody

Target: C2orf40 (Chromosome 2 Open Reading Frame 40 (C2orf40))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C2orf40 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ECRG4/C2orf40

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for C2orf40

Target: C2orf40 (Chromosome 2 Open Reading Frame 40 (C2orf40))

Alternative Name: ECRG4 (C2orf40 Products)

Synonyms: ECRG4 antibody, ecrg4 antibody, ecrg4-A antibody, Ecrg4 antibody, chromosome 2 open reading frame, human C2orf40 antibody, chromosome 13 open reading frame, human C2orf40 antibody, chromosome 11 open reading frame, human C2orf40 antibody, chromosome 2 open reading frame 40 antibody, chromosome 2 open reading frame 40 L homeolog antibody, RIKEN cDNA 1500015O10 gene antibody, similar to RIKEN cDNA 1500015O10 antibody, C2H2orf40 antibody, C13H2orf40 antibody, C11H2orf40 antibody, C2orf40 antibody, c2orf40.L antibody, 1500015O10Rik antibody, RGD1305645 antibody

Background:

Synonyms: AUGN_HUMAN, Augurin, C2orf40, Esophageal cancer-related gene 4 protein.

Background: ECRG4, also known as augurin or C2orf40, is a 148 amino acid secreted protein. Belonging to the augurin family, ECRG4 is thought to be a hormone. It has also been suggested that ECRG4 may act as a tumor suppressor. The gene that encodes ECRG4 maps to human chromosome 2, which consists of 237 million bases encoding over 1,400 genes, making up approximately 8 % of the human genome. A number of genetic diseases are linked to genes on chromosome 2. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene. The lipid metabolic disorder sitosterolemia is associated with ABCG5 and ABCG8. An extremely rare recessive genetic disorder, Alstr syndrome is due to mutations in the ALMS1 gene. Interestingly, chromosome 2 contains what appears to be a vestigial second centromere and vestigial telomeres which gives credence to the hypothesis that human chromosome 2 is the result of an ancient fusion of two ancestral chromosomes.

Gene ID: 84417