anti-Chromosome 8 Open Reading Frame 4 (C8orf4) Antibodies

C8orf4 encodes a member of the vitamin B12-binding protein family. Additionally we are shipping and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
C8orf4 56892 Q9NR00
C8orf4    
C8orf4    
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Top anti-C8orf4 Antibodies at antibodies-online.com

Showing 10 out of 33 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-C8orf4 Antibody Titration: 1.0 ug/ml Positive Control: 293T Whole Cell 100 μL 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC, WB Immunohistochemistry of paraffin-embedded rat lung using C8orf4 antibody at dilution of 1:100 (40x lens). Immunohistochemistry of paraffin-embedded human stomach using C8orf4 antibody at dilution of 1:100 (40x lens). 100 μL 11 to 13 Days
$366.77
Details
Human Rabbit Un-conjugated IHC, WB Immunohistochemistry of paraffin-embedded rat lung using C8orf4 antibody (ABIN5975014) at dilution of 1/100 (40x lens). Immunohistochemistry of paraffin-embedded human stomach using C8orf4 antibody (ABIN5975014) at dilution of 1/100 (40x lens). 100 μL 11 to 16 Days
$426.40
Details
Guinea Pig Rabbit Un-conjugated WB   100 μL 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated IHC Immunohistochemistry of paraffin-embedded rat lung using C8orf4 antibody. Immunohistochemistry of paraffin-embedded mouse brain using C8orf4 antibody. 200 μL 12 to 14 Days
$438.90
Details
Human Rabbit Un-conjugated IHC (p) Immunohistochemical staining of human duodenum with C8orf4 polyclonal antibody  shows moderate nuclear and cytoplasmic positivity in glandular cells at 1:200-1:500 dilution. 100 μL 11 to 12 Days
$577.33
Details
Human Rabbit Alexa Fluor 488 IF (p)   100 μL 3 to 7 Days
$416.90
Details
Human Rabbit Alexa Fluor 555 IF (p)   100 μL 3 to 7 Days
$416.90
Details
Human Rabbit Alexa Fluor 647 IF (p)   100 μL 3 to 7 Days
$416.90
Details
Human Rabbit Alexa Fluor 350 IF (p)   100 μL 3 to 7 Days
$416.90
Details

Top referenced anti-C8orf4 Antibodies

  1. Human Polyclonal C8orf4 Primary Antibody for IHC, IHC (p) - ABIN4358061 : Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013 (PubMed)

More Antibodies against C8orf4 Interaction Partners

Human Chromosome 8 Open Reading Frame 4 (C8orf4) interaction partners

  1. The expressions of C8orf4 (TCIM) and beta-catenin increase synergystically in cervical squamous cell carcinoma (CSCC) and high-grade intraepithelial lesions compared with low-grade lesions and normal cervical tissues. The methylation level of C8orf4 is decreased in CSCCs and is responsible for the increased expression of C8orf4.

  2. Identified a new circRNA, circZFR, that was significantly upregulated in papillary thyroid carcinoma (PTC). CircZFR could promote C8orf4 expression via serving as a competing endogenous RNA of miR-1261 in PTC cells. Rescue assays indicated that restoration of C8orf4 significantly attenuated the inhibitory effects of circZFR knockdown on PTC cell proliferation, migration and invasion.

  3. Decreased capacity of fibrotic lung fibroblasts to up-regulate COX-2 expression and COX-2-derived PGE2 synthesis is due to an indirect epigenetic mechanism involving hypermethylation of the transcriptional regulator, c8orf4.

  4. C8orf4 negatively regulates the self-renewal of liver CSCs via suppression of NOTCH2 signalling

  5. the high expression of TC1 was common in oral tongue squamous cell carcinomas and correlated with the expression of b-catenin and cyclin D1 and the progression of oral tongue squamous cell carcinomas

  6. TC-1 overexpression promotes cell proliferation in human non-small cell lung cancer that can be inhibited by PD173074.

  7. TC-1 expression is associated with aggressive biologic behavior in lung cancer and might coordinate with the Wnt/beta-catenin pathway as a positive upstream regulator that induces these behaviors.

  8. The higher expression of TC-1 in ovarian compared to colorectal adenocarcinomas suggests its potential use as a marker

  9. The SNP rs10958605 in the C8orf4 gene had the smallest p value in analyses of the motor outcome.

  10. A significant association was found between the copy-number deletions of C8orf4 and the risk of hematological malignancies.

  11. Overexpression of TC-1 may be important in thyroid carcinogenesis.

  12. data indicate that TC1 is a novel upstream regulator of the Wnt/beta-catenin pathway that enhances aggressive behavior of cancers

  13. The TC1 coordinates the up-regulation of Wnt/beta-catenin target genes that are implicated in the aggressive biological behavior of cancers.

  14. Gene induces transformed phenotype when overexpressed in a cancer breast cell line.

  15. TC-1 over expression is transforming and may link with the FGFR pathway in a subset of breast cancer.

  16. Our data suggest that TC1 is a novel heat shock response regulator.

  17. intrinsically disordered TC-1 interacts with Cby via its transient helical structure

  18. TC1 was involved in the mitogen-activated ERK1/2 signaling pathway and positively regulated G(1)- to S-phase transition of the cell cycle.

C8orf4 Antigen Profile

Protein Summary

This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt\\/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1\\/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies.

Gene names and symbols associated with C8orf4

  • transcriptional and immune response regulator (TCIM) antibody
  • chromosome 22 open reading frame, human C8orf4 (C22H8ORF4) antibody
  • TC-1 antibody
  • TC1 antibody

Protein level used designations for C8orf4

human thyroid cancer 1 , thyroid cancer protein 1 , uncharacterized protein C8orf4 , chromosome 8 open reading frame 4

GENE ID SPECIES
56892 Homo sapiens
771032 Gallus gallus
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