anti-Cleavage and Polyadenylation Specific Factor 4, 30kDa Antibodies
Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain.
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anti-Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4) (C-Term) antibody Primary Antibody
anti-Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4) antibody Primary Antibody
anti-Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4) (AA 96-114) antibody Primary Antibody
anti-Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4) antibody Primary Antibody
anti-Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4) (C-Term) antibody Primary Antibody
anti-Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4) (AA 96-123), (Center) antibody Primary Antibody
anti-Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4) (AA 102-132), (Middle Region) antibody Primary Antibody
anti-Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4) antibody Primary Antibody
anti-Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4) (C-Term) antibody Primary Antibody
anti-Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4) (AA 1-244) antibody Primary Antibody
Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4) Antigen Profile
Protein Summary
Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene.
Gene names and symbols associated with CPSF4
- cleavage and polyadenylation specific factor 4 (CPSF4) antibody
- cleavage and polyadenylation specific factor 4, 30kDa (Cpsf4) antibody
- cleavage and polyadenylation specific factor 4 (LOC733099) antibody
- cleavage and polyadenylation specific factor 4 (LOC100360200) antibody
- cleavage and polyadenylation specific factor 4 S homeolog (cpsf4.S) antibody
- cleavage and polyadenylation specific factor 4 (cpsf4) antibody
- cleavage and polyadenylation specific factor 4 (Cpsf4) antibody
- 30kDa antibody
- C79664 antibody
- CPSF30 antibody
- NAR antibody
- NEB1 antibody
Protein level used designations for CPSF4
no arches , GLEAN_10339 , cleavage and polyadenylation specific factor 4 , cleavage and polyadenylation specificity factor subunit 4 , cleavage and polyadenylation specific factor 4, 30kDa , CPSF 30 kDa subunit , cleavage and polyadenylation specific factor 4, 30kD subunit , cleavage and polyadenylation specificity factor 30 kDa subunit , clipper homolog , clipper/CPSF 30K , musculus clipper/cleavage and polyadenylation specificity factor 30 kDa subunit , NS1 effector domain-binding protein 1 , cleavage-polyadenylation specificity factor, 30kD , neb-1 , no arches homolog , no arches-like zinc finger protein , cleavage-polyadenylation specificity factor, 30 kD
| GENE ID | SPECIES |
|---|---|
| 463572 | Pan troglodytes |
| 660072 | Tribolium castaneum |
| 733099 | Bombyx mori |
| 100360200 | Rattus norvegicus |
| 444766 | Xenopus laevis |
| 493312 | Xenopus (Silurana) tropicalis |
| 708119 | Macaca mulatta |
| 100224162 | Taeniopygia guttata |
| 54188 | Mus musculus |
| 304277 | Rattus norvegicus |
| 10898 | Homo sapiens |
| 416494 | Gallus gallus |
| 489859 | Canis lupus familiaris |
| 280875 | Bos taurus |
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