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anti-Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4) Antibodies

Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. Additionally we are shipping Cleavage and Polyadenylation Specific Factor 4, 30kDa Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CPSF4 100360200  
CPSF4 54188 Q8BQZ5
CPSF4 10898 O95639
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Top anti-Cleavage and Polyadenylation Specific Factor 4, 30kDa Antibodies at antibodies-online.com

Showing 10 out of 71 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-CPSF4 Antibody Titration: 0.2-1 ug/ml Positive Control: Jurkat cell lysate CPSF4 is supported by BioGPS gene expression data to be expressed in Jurkat 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of CPSF4 Antibody (Center) in Jurkat cell line lysates (35ug/lane).CPSF4 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 11 to 14 Days
$507.83
Details
Human Rabbit Un-conjugated WB Western blot analysis of CPSF4 Antibody (Center) (ABIN653570) in Jurkat cell line lysates (35 µg/lane).CPSF4 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated IP, WB 100 μL Log in to see 7 to 9 Days
$559.35
Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of HeLa cells, using CPSF4 antibody. ABIN6273104 at 1/100 staining Human gastric tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated IP, WB 0.1 mL Log in to see 7 to 9 Days
$559.35
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human gastric carcinoma labeled with Anti-CPSF4/CPSF30 Polyclonal Antibody, Unconjugated (ABIN1386751) at 1:200 followed by conjugation to the secondary antibody and DAB staining Lane 1: rat brain lysates Lane 2: human colon carcinoma lysates probed with Anti CPSF4/CPSF30 Polyclonal Antibody, Unconjugated (ABIN1386751) at 1:200 in 4 °C. Followed by conjugation to secondary antibody at 1:3000 90min in 37 °C. Predicted band 27kD. Observed band size: 23kD, 27kD. 100 μL Log in to see 3 to 7 Days
$317.90
Details
Human Rabbit Un-conjugated WB Western blot analysis of extract of various cells, using CPSF4 antibody. Western blot analysis of extracts of various cell lines, using CPSF4 antibody (ABIN4903367) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 15s. 100 μL Log in to see 11 to 13 Days
$366.77
Details
Human Rabbit Un-conjugated WB Western blot analysis of CPSF4 Antibody in Jurkat cell line lysates (35ug/lane) 400 μL Log in to see 2 to 3 Days
$515.63
Details

Top referenced anti-Cleavage and Polyadenylation Specific Factor 4, 30kDa Antibodies

  1. Human Polyclonal CPSF4 Primary Antibody for IP, WB - ABIN256698 : Li, Noah, Noah: Alanine substitutions within a linker region of the influenza A virus non-structural protein 1 alter its subcellular localization and attenuate virus replication. in The Journal of general virology 2011 (PubMed)

More Antibodies against Cleavage and Polyadenylation Specific Factor 4, 30kDa Interaction Partners

Human Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4) interaction partners

  1. The authors define the molecular architecture of the core human CPSF complex comprising CPSF160, WDR33, CPSF30 and Fip1 and identify specific domains involved in inter-subunit interactions. Together, these results shed light on the function of CPSF in mediating polyA signal-dependent RNA cleavage and polyadenylation.

  2. Residues F103 and M106 within the NS1-CPSF4 binding region are important for viral replication.

  3. Cleavage and polyadenylation specific factor 4 targets NF-kappaB/cyclooxygenase-2 signaling to promote the growth and survival of non-small cell lung carcinoma cells.

  4. These findings support a role for iron in some zinc-finger proteins. Using electrophoretic mobility shift assays and fluorescence anisotropy, we report that CPSF30 selectively recognizes the AU-rich hexamer (AAUAAA) sequence present in pre-mRNA, providing the first molecular-based evidence to our knowledge for CPSF30/RNA binding.

  5. unexpectedly found that CPSF subunits CPSF30 and Wdr33 directly contact AAUAAA

  6. CPSF4 upregulates human TERT promoter activity, human TERT expression and telomerase activity.

  7. Data show that 4 drug-like compounds from traditional Chinese Medicine (TCM) database were selected as potential inhibitors for the cleavage and polyadenylation specific factor CPSF30-binding site of influenza A virus of non-structural protein 1 (NS1A).

  8. CPSF4 plays a critical role in regulating lung cancer cell proliferation and survival and may be a potential prognostic biomarker and therapeutic target for lung adenocarcinoma.

  9. Data show that the NS1A protein of the pathogenic H5N1 influenza A/Hong Kong/483/97 (HK97) virus isolated from humans has an intrinsic defect in CPSF30 binding.

Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4) Antigen Profile

Protein Summary

Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene.

Gene names and symbols associated with CPSF4

  • cleavage and polyadenylation specific factor 4 (CPSF4) antibody
  • cleavage and polyadenylation specific factor 4, 30kDa (Cpsf4) antibody
  • cleavage and polyadenylation specific factor 4 (LOC733099) antibody
  • cleavage and polyadenylation specific factor 4 (LOC100360200) antibody
  • cleavage and polyadenylation specific factor 4 S homeolog (cpsf4.S) antibody
  • cleavage and polyadenylation specific factor 4 (cpsf4) antibody
  • cleavage and polyadenylation specific factor 4 (Cpsf4) antibody
  • 30kDa antibody
  • C79664 antibody
  • CPSF30 antibody
  • NAR antibody
  • NEB1 antibody

Protein level used designations for CPSF4

no arches , GLEAN_10339 , cleavage and polyadenylation specific factor 4 , cleavage and polyadenylation specificity factor subunit 4 , cleavage and polyadenylation specific factor 4, 30kDa , CPSF 30 kDa subunit , cleavage and polyadenylation specific factor 4, 30kD subunit , cleavage and polyadenylation specificity factor 30 kDa subunit , clipper homolog , clipper/CPSF 30K , musculus clipper/cleavage and polyadenylation specificity factor 30 kDa subunit , NS1 effector domain-binding protein 1 , cleavage-polyadenylation specificity factor, 30kD , neb-1 , no arches homolog , no arches-like zinc finger protein , cleavage-polyadenylation specificity factor, 30 kD

GENE ID SPECIES
463572 Pan troglodytes
660072 Tribolium castaneum
733099 Bombyx mori
100360200 Rattus norvegicus
444766 Xenopus laevis
493312 Xenopus (Silurana) tropicalis
708119 Macaca mulatta
100224162 Taeniopygia guttata
54188 Mus musculus
304277 Rattus norvegicus
10898 Homo sapiens
416494 Gallus gallus
489859 Canis lupus familiaris
280875 Bos taurus
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