Coagulation Factor V Proteins (F5)

F5 encodes an essential cofactor of the blood coagulation cascade. Additionally we are shipping Coagulation Factor V Antibodies (119) and Coagulation Factor V Kits (63) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
F5 14067 O88783
F5 2153 P12259
Rat F5 F5 304929  
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Top Coagulation Factor V Proteins at

Showing 10 out of 23 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 15 to 18 Days
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 18 Days
Escherichia coli (E. coli) Cow His tag,GST tag 100 μg Log in to see 15 to 18 Days
Human Human Un-conjugated   0.05 mg Log in to see 2 to 3 Days
Escherichia coli (E. coli) Wild boar His tag 100 μg Log in to see 15 to 18 Days
Escherichia coli (E. coli) Cow T7 tag,His tag 100 μg Log in to see 15 to 18 Days
Escherichia coli (E. coli) Pig Un-conjugated   100 μg Log in to see 11 to 18 Days

F5 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,

Human , , ,

More Proteins for Coagulation Factor V (F5) Interaction Partners

Mouse (Murine) Coagulation Factor V (F5) interaction partners

  1. Platelet-derived FV contributes to the control of angiogenesis and is likely associated with thrombin (show F2 Proteins) generation in hind limb ischemia model.

  2. These findings reveal a novel biological function and mechanism of the protein C (show PROC Proteins) pathway in which protein S and the aPC (show APC Proteins)-cleaved form of fV are cofactors for anti-inflammatory cell signaling by aPC (show APC Proteins) in the context of endotoxemia and infection

  3. Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of alpha1-antitrypsin.

  4. The FVL mutation does not influence coagulation activation, lung inflammation or survival in lethal influenza A.

  5. It suggested that there could be a combination of GLA (show GLA Proteins) deficiency and FVL or other thrombosis-related gene defect in patients with genetic severe early-onset thrombosis.

  6. Data suggest that tissue factor (show F3 Proteins) and factor V induction by LPS (show TLR4 Proteins) may in part accelerate mesangioproliferative glomerulonephritis through activation of factor X and downstream proinflammatory and procoagulant mechanisms.

  7. The source of the FVL leading to accelerated thrombosis appears to be circulating, non-platelet-derived plasma FVL.

  8. FVL has the ability to improve the hemophilia A or B phenotype, but this effect is principally evident at the microcirculation level following a particular vascular injury.

  9. observations demonstrate a synergistic interaction between alpha-galactosidase A (show GLA Proteins) deficiency and Factor V Leiden toward tissue fibrin deposition; concomitant mutations in these genes may increase the penetrance of vascular thrombotic events in humans

  10. Fetal gene defects precipitate platelet-mediated pregnancy failure in factor V Leiden mothers.

Human Coagulation Factor V (F5) interaction partners

  1. There were no significant differences in factor V and factor II genotypes between infertile men and normal controls.

  2. FVBonn induces hypercoagulability via a combination of increased activation/procoagulant activity, decreased susceptibility to Activated protein C-mediated inactivation, and slightly reduced APC (show APC Proteins) cofactor activity

  3. prothrombotic mutations in factor V Leiden and prothrombin (show F2 Proteins) as well as older age are risk factors for venous thrombosis

  4. Heterozygous FV Leiden, homozygous PAI-1 4G/4G, heterozygous MTHFR C677T, homozygous MTHFR A1298C, as much as the combined thrombophilic genotypes MTHFR 677T + ACE Iota/D, MTHFR 677T/1298C + ACE D/D, ACE I/D + b-fibrinogen -455 G/A, FV HR2 + b-fibrinogen -455 G/A showed a correlation as risk factors for Recurrent pregnancy loss.

  5. the signaling and anticoagulant functions of APC (show APC Proteins) are in spatially and kinetically distinct compartments, and that it is possible to specifically inhibit the anticoagulant activity of APC (show APC Proteins). Targeting APC (show APC Proteins) with a serpin is remarkably effective and may be safe for long-term prophylactic use in the treatment of hemophilia.

  6. Cleavage of FV at Arg(1545) , which abolishes the anticoagulant properties of FV and commits FV to the procoagulant pathway, is inhibited by binding of the TFPIalpha C-terminus to the FV acidic region

  7. The goal of this study was to evaluate the impact of EHR point-of-care tools on medical record documentation of genetic testing care processes for the common HFE mutations, a thrombophilia panel, and HLA-B27.

  8. The prevalence of FVL polymorphism (16.3 %) was higher in retinopathy of prematurity (ROP (show STXBP1 Proteins)) patients than control subjects in this Turkish cohort. We suggest a possible association of FVL mutation with ROP (show STXBP1 Proteins) at the end of the study.

  9. Factor Va reduced by 100-fold the apparent Kd of myosin for factor Xa (show F10 Proteins) (Kd approximately 0.48 nM), primarily by reducing koff, indicating formation of a stable ternary complex of myosin:Xa:Va.

  10. there is a synergistic effect of the FVL and rs4524 single nucleotide polymorphisms and active cancer on the risk of VTE.

Cow (Bovine) Coagulation Factor V (F5) interaction partners

  1. Data suggest factor Xa (FXa (show F10 Proteins)) and factor Va (FVa) compete to bind FXa (show F10 Proteins) on both PS model membranes and microparticles from activated platelets; this competition between dimerization/prothrombinase (show FGL2 Proteins) complex formation appears to regulate blood coagulation.

Coagulation Factor V (F5) Protein Profile

Protein Summary

This gene encodes an essential cofactor of the blood coagulation cascade. This factor circulates in plasma, and is converted to the active form by the release of the activation peptide by thrombin during coagulation. This generates a heavy chain and a light chain which are held together by calcium ions. The activated protein is a cofactor that participates with activated coagulation factor X to activate prothrombin to thrombin. Defects in this gene result in either an autosomal recessive hemorrhagic diathesis or an autosomal dominant form of thrombophilia, which is known as activated protein C resistance.

Gene names and symbols associated with Coagulation Factor V Proteins (F5)

  • coagulation factor V (f5)
  • coagulation factor V (F5)
  • Ac2-120 protein
  • AI173222 protein
  • Cf-5 protein
  • Cf5 protein
  • FVL protein
  • PCCF protein
  • RPRGL1 protein
  • THPH2 protein

Protein level used designations for Coagulation Factor V Proteins (F5)

coagulation factor V , activated protein C cofactor , activated protein c cofactor , coagulation factor V jinjiang A2 domain , factor V Leiden , proaccelerin, labile factor

100534566 Oreochromis niloticus
14067 Mus musculus
2153 Homo sapiens
304929 Rattus norvegicus
280687 Bos taurus
100715882 Cavia porcellus
397217 Sus scrofa
100685858 Canis lupus familiaris
101123649 Ovis aries
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