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CCDC8 encodes a coiled-coil domain-containing protein. Additionally we are shipping Coiled-Coil Domain Containing 8 Kits (12) and Coiled-Coil Domain Containing 8 Proteins (3) and many more products for this protein.
Showing 10 out of 47 products:
Human Polyclonal CCDC8 Primary Antibody for IP, WB - ABIN4288660 : Dai, Tang, Jung, Qin, Aaronson, Gu: Differential effects on p53-mediated cell cycle arrest vs. apoptosis by p90. in Proceedings of the National Academy of Sciences of the United States of America 2011 (PubMed) Show all 2 Pubmed References
Human Polyclonal CCDC8 Primary Antibody for WB - ABIN949718 : Hanson, Murray, OSullivan, Urquhart, Daly, Bhaskar, Biesecker, Skae, Smith, Cole, Kirk, Chandler, Kingston, Donnai, Clayton, Black: Exome sequencing identifies CCDC8 mutations in 3-M syndrome, suggesting that CCDC8 contributes in a pathway with CUL7 and OBSL1 to control human growth. in American journal of human genetics 2011 (PubMed)
Human Polyclonal CCDC8 Primary Antibody for ICC, IF - ABIN4288662 : Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013 (PubMed)
Variants near TTN and CCDC8 were associated with KI67 expression, and rs2288563 and rs2562832 in TTN are potential biomarkers for the prediction of clinical outcomes in hepatitis B-related hepatocellular carcinoma patients.
CCDC8 may suppress the invasion and metastasis of non-small cell lung cancer cells.
CUL7, OBSL1 and CCDC8 modulate the alternative splicing of the INSR
The CUL7, OBSL1, and CCDC8 proteins form a 3M complex that functions in maintaining microtubule and genome integrity and normal development.
Mutations in CUL7, OBSL1 and CCDC8 in 3-M syndrome lead to disordered growth factor signalling.
discussion of roles of CCDC8, CUL7 (cullin 7), and OBSL1 (obscurin-like 1) in growth and development using findings from patients with Miller-McKusick-Malvaux syndrome and Silver-Russell syndrome [REVIEW]
p90 is a critical cofactor for p53-mediated apoptosis through promoting Tip60-mediated p53 acetylation.
We propose that CUL7, OBSL1, and CCDC8 are members of a pathway controlling mammalian growth.
This gene encodes a coiled-coil domain-containing protein. The encoded protein functions as a cofactor required for p53-mediated apoptosis following DNA damage, and may also play a role in growth through interactions with the cytoskeletal adaptor protein obscurin-like 1. Mutations in this gene are a cause of 3M syndrome-3 (3M3).
coiled-coil domain-containing protein 8 , protein phosphatase 1, regulatory subunit 20 , probable Coiled-coil domain-containing protein 8 , coiled-coil domain-containing protein 8 homolog