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anti-Coiled-Coil Domain Containing 8 (CCDC8) Antibodies

CCDC8 encodes a coiled-coil domain-containing protein. Additionally we are shipping Coiled-Coil Domain Containing 8 Kits (12) and Coiled-Coil Domain Containing 8 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CCDC8 83987 Q9H0W5
CCDC8 494320 P62521
CCDC8 434130 D3YZV8
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Top anti-Coiled-Coil Domain Containing 8 Antibodies at antibodies-online.com

Showing 10 out of 47 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB CCDC8 antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human tonsil tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CCDC8 antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. CCDC8 Antibody (C-term) western blot analysis in Jurkat cell line lysates (35µg/lane).This demonstrates the CCDC8 antibody detected the CCDC8 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated IHC (p), WB CCDC8 antibody (C-term) (ABIN654511) immunohistochemistry analysis in formalin fixed and paraffin embedded human tonsil tissue followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Western blot analysis of CCDC8 using HuvEc whole cell lysates ABIN6279318 at 1/100 staining Mouse muscle tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated IP, WB Western Blot: CCDC8 Antibody [NBP1-50021] - Detection of Human CCDC8 by Western Blot and Immunoprecipitation. Samples: Whole cell lysate from 293T (5, 15 and 50 mcg for WB; 1 mg for IP, 20% of IP loaded) and K562 (K; 50 mcg) cells. Antibodies: Affinity purified rabbit anti-CCDC8 antibody used for WB at 0.04 mcg/ml (A) and 0.1 mcg/ml (B) and used for IP at 6 mcg/mg lysate. CCDC8 was also immunoprecipitated by rabbit anti-CCDC8 antibody which recognizes a downstream epitope. For blotting immunoprecipitated CCDC8, the ReliaBLOT (R) Reagents and Procedures were used. Detection: Chemiluminescence with exposure times of 10 seconds (A and B). 0.1 mL Log in to see 7 to 9 Days
$559.35
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: CCDC8 Antibody [NBP1-85085] - Staining of human cell line A-431 shows positivity in plasma membrane & cytoplasm. Western Blot: CCDC8 Antibody [NBP1-85085] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.Lane 2: Human cell line RT-4.Lane 3: Human cell line U-251MG sp.Lane 4: Human plasma (IgG/HSA depleted).Lane 5: Human liver tissue.Lane 6: Human tonsil tissue 0.1 mL Log in to see 10 to 13 Days
$494.38
Details
Human Mouse Un-conjugated WB Western Blot analysis of CCDC8 expression in transfected 293T cell line by CCDC8 MaxPab polyclonal antibody.Lane 1: CCDC8 transfected lysate(59.40 KDa).Lane 2: Non-transfected lysate. CCDC8 MaxPab polyclonal antibody. Western Blot analysis of CCDC8 expression in human spleen. 50 μg Log in to see 11 to 12 Days
$440.00
Details
Human Rabbit Un-conjugated ELISA, WB   100 μL Log in to see 16 Days
$293.00
Details
Human Rabbit Un-conjugated IP Immunoprecipitation: CCDC8 Antibody [NBP1-50022] - Detection of Human CCDC8 by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from 293T cells. Antibodies: Affinity purified rabbit anti-CCDC8 antibody used for IP at 6 mcg/mg lysate. CCDC8 was also immunoprecipitated by rabbit anti-CCDC8 antibody which recognizes an upstream epitope. For blotting immunoprecipitated CCDC8 was used at 0.4 mcg/ml, and the ReliaBLOT Reagents and Procedures were incorporated. Detection: Chemiluminescence with an exposure time of 10 seconds. 100 μL Log in to see 7 to 9 Days
$559.35
Details
Human Rabbit Un-conjugated IHC, ELISA, WB   200 μL Log in to see 11 to 16 Days
$658.43
Details
Human Rabbit HRP IHC (p), WB   100 μL Log in to see 14 to 21 Days
$416.90
Details

Top referenced anti-Coiled-Coil Domain Containing 8 Antibodies

  1. Human Polyclonal CCDC8 Primary Antibody for IP, WB - ABIN4288660 : Dai, Tang, Jung, Qin, Aaronson, Gu: Differential effects on p53-mediated cell cycle arrest vs. apoptosis by p90. in Proceedings of the National Academy of Sciences of the United States of America 2011 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal CCDC8 Primary Antibody for WB - ABIN949718 : Hanson, Murray, OSullivan, Urquhart, Daly, Bhaskar, Biesecker, Skae, Smith, Cole, Kirk, Chandler, Kingston, Donnai, Clayton, Black: Exome sequencing identifies CCDC8 mutations in 3-M syndrome, suggesting that CCDC8 contributes in a pathway with CUL7 and OBSL1 to control human growth. in American journal of human genetics 2011 (PubMed)

  3. Human Polyclonal CCDC8 Primary Antibody for ICC, IF - ABIN4288662 : Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013 (PubMed)

More Antibodies against Coiled-Coil Domain Containing 8 Interaction Partners

Human Coiled-Coil Domain Containing 8 (CCDC8) interaction partners

  1. Variants near TTN and CCDC8 were associated with KI67 expression, and rs2288563 and rs2562832 in TTN are potential biomarkers for the prediction of clinical outcomes in hepatitis B-related hepatocellular carcinoma patients.

  2. CCDC8 may suppress the invasion and metastasis of non-small cell lung cancer cells.

  3. CUL7, OBSL1 and CCDC8 modulate the alternative splicing of the INSR

  4. The CUL7, OBSL1, and CCDC8 proteins form a 3M complex that functions in maintaining microtubule and genome integrity and normal development.

  5. Mutations in CUL7, OBSL1 and CCDC8 in 3-M syndrome lead to disordered growth factor signalling.

  6. discussion of roles of CCDC8, CUL7 (cullin 7), and OBSL1 (obscurin-like 1) in growth and development using findings from patients with Miller-McKusick-Malvaux syndrome and Silver-Russell syndrome [REVIEW]

  7. p90 is a critical cofactor for p53-mediated apoptosis through promoting Tip60-mediated p53 acetylation.

  8. We propose that CUL7, OBSL1, and CCDC8 are members of a pathway controlling mammalian growth.

Coiled-Coil Domain Containing 8 (CCDC8) Antigen Profile

Protein Summary

This gene encodes a coiled-coil domain-containing protein. The encoded protein functions as a cofactor required for p53-mediated apoptosis following DNA damage, and may also play a role in growth through interactions with the cytoskeletal adaptor protein obscurin-like 1. Mutations in this gene are a cause of 3M syndrome-3 (3M3).

Gene names and symbols associated with CCDC8

  • coiled-coil domain containing 8 (CCDC8) antibody
  • coiled-coil domain containing 8 (Ccdc8) antibody
  • 3M3 antibody
  • ENSMUSG00000041117 antibody
  • p90 antibody
  • PPP1R20 antibody

Protein level used designations for CCDC8

coiled-coil domain-containing protein 8 , protein phosphatase 1, regulatory subunit 20 , probable Coiled-coil domain-containing protein 8 , coiled-coil domain-containing protein 8 homolog

GENE ID SPECIES
83987 Homo sapiens
494320 Rattus norvegicus
484430 Canis lupus familiaris
434130 Mus musculus
100725448 Cavia porcellus
101116079 Ovis aries
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