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Required for the localization of dynein and dynactin to the mitotic kintochore.
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Spindly is a novel regulator of mitotic dynein, functioning specifically to target dynein to kinetochores.
posttranslational modification of TCP14/15 by SPY inhibits their proteolysis.
The study revealed that SPY-dependent protein O-fucosylation plays a key role in regulating plant development.
SPINDLY regulates cortex proliferation by maintaining cellular redox homeostasis
SPY plays a negative role in plant abiotic stress tolerance, probably by integrating environmental stress signals via gibberellic acid and Cytokinins cross talk.
Data suggest that responses of leaves and flowers to CK are mediated by SPY-dependent TCP14 and TCP15 activities.
spy-4 partially suppressed the reduced abundance of CONSTANS and FLOWERING LOCUS T RNA and the late flowering of gigantea mutant plants
Our results demonstrate that SPY acts as both a repressor of GA responses and a positive regulator of cytokinin signaling. Hence, SPY may play a central role in the regulation of GA/cytokinin cross talk during plant development.
SPY acts in the cytosol to suppress gibberellin responses and to promote cytokinin signaling.
Farnesylation of Spindly is essential for its localization, & thus for proper localization of dynein & dynactin (show DCTN1 Proteins), to prometaphase kinetochores. Both Spindly and CENP-E (show CENPE Proteins) farnesylation are required for efficient chromosome congression
hSpindly is farnesylated in vivo and farnesylation is essential for its interaction with the RZZ complex and hence Kinetochore localization.
Spindly is not only required for kinetochore localization of dynein but is a functional component of a mechanism that couples dynein-dependent poleward movement of chromosomes to their efficient attachment to microtubules.
dynein-mediated removal of Spindly from microtubule-attached kinetochores, rather than poleward transport per se, is the critical reaction in checkpoint silencing
[hSpindly] Localization of human Spindly (hSpindly) to kinetochores is controlled by the Rod/Zw10 (show ZW10 Proteins)/Zwilch (show ZWILCH Proteins) (RZZ) complex and Aurora B (show AURKB Proteins).
Overexpression of mSpindly failed to enhance inactivation of SAC (show ADCY10 Proteins) and acceleration of the meiotic process.
Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex (By similarity).
, coiled-coil domain containing 99
, coiled-coil domain-containing protein 99
, protein Spindly
, spindle apparatus coiled-coil domain-containing protein 1
, arsenite-related gene 1 protein
, rhabdomyosarcoma antigen MU-RMS-40.4A
, rrhabdomyosarcoma antigen protein MU-RMS-40.4A
, spindly homolog
, Coiled-coil domain-containing protein 99-A
, protein Spindly-A
, spindle apparatus coiled-coil domain-containing protein 1-A