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Coiled-Coil Domain Containing 99 Proteins (CCDC99)

Required for the localization of dynein and dynactin to the mitotic kintochore.

list all proteins Gene Name GeneID UniProt
Human CCDC99 CCDC99 54908 Q96EA4
Mouse CCDC99 CCDC99 70385 Q923A2
Rat CCDC99 CCDC99 303037 Q3KR99
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Top Coiled-Coil Domain Containing 99 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$8,498.50
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Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$8,498.50
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$547.80
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,719.83
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More Proteins for Coiled-Coil Domain Containing 99 (CCDC99) Interaction Partners

Fruit Fly (Drosophila melanogaster) Coiled-Coil Domain Containing 99 (CCDC99) interaction partners

  1. Spindly is a novel regulator of mitotic dynein, functioning specifically to target dynein to kinetochores.

Arabidopsis thaliana Coiled-Coil Domain Containing 99 (CCDC99) interaction partners

  1. posttranslational modification of TCP14/15 by SPY inhibits their proteolysis.

  2. The study revealed that SPY-dependent protein O-fucosylation plays a key role in regulating plant development.

  3. SPINDLY regulates cortex proliferation by maintaining cellular redox homeostasis

  4. SPY plays a negative role in plant abiotic stress tolerance, probably by integrating environmental stress signals via gibberellic acid and Cytokinins cross talk.

  5. Data suggest that responses of leaves and flowers to CK are mediated by SPY-dependent TCP14 and TCP15 activities.

  6. spy-4 partially suppressed the reduced abundance of CONSTANS and FLOWERING LOCUS T RNA and the late flowering of gigantea mutant plants

  7. Our results demonstrate that SPY acts as both a repressor of GA responses and a positive regulator of cytokinin signaling. Hence, SPY may play a central role in the regulation of GA/cytokinin cross talk during plant development.

  8. SPY acts in the cytosol to suppress gibberellin responses and to promote cytokinin signaling.

Human Coiled-Coil Domain Containing 99 (CCDC99) interaction partners

  1. Farnesylation of Spindly is essential for its localization, & thus for proper localization of dynein & dynactin (show DCTN1 Proteins), to prometaphase kinetochores. Both Spindly and CENP-E (show CENPE Proteins) farnesylation are required for efficient chromosome congression

  2. hSpindly is farnesylated in vivo and farnesylation is essential for its interaction with the RZZ complex and hence Kinetochore localization.

  3. Spindly is not only required for kinetochore localization of dynein but is a functional component of a mechanism that couples dynein-dependent poleward movement of chromosomes to their efficient attachment to microtubules.

  4. dynein-mediated removal of Spindly from microtubule-attached kinetochores, rather than poleward transport per se, is the critical reaction in checkpoint silencing

  5. [hSpindly] Localization of human Spindly (hSpindly) to kinetochores is controlled by the Rod/Zw10 (show ZW10 Proteins)/Zwilch (show ZWILCH Proteins) (RZZ) complex and Aurora B (show AURKB Proteins).

Mouse (Murine) Coiled-Coil Domain Containing 99 (CCDC99) interaction partners

  1. Overexpression of mSpindly failed to enhance inactivation of SAC (show ADCY10 Proteins) and acceleration of the meiotic process.

Coiled-Coil Domain Containing 99 (CCDC99) Protein Profile

Protein Summary

Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex (By similarity).

Gene names and symbols associated with CCDC99

  • CG15415 gene product from transcript CG15415-RB (Spindly)
  • Tetratricopeptide repeat (TPR)-like superfamily protein (SPY)
  • spindle apparatus coiled-coil protein 1 (spdl1)
  • spindle apparatus coiled-coil protein 1 (SPDL1)
  • spindle apparatus coiled-coil protein 1 (Spdl1)
  • spindle apparatus coiled-coil protein 1 L homeolog (spdl1.L)
  • 1700018I02Rik protein
  • 2600001J17Rik protein
  • 2810049B11Rik protein
  • AA409762 protein
  • Ccdc99 protein
  • ccdc99-a protein
  • ccdc99-b protein
  • CG15415 protein
  • Dmel\\CG15415 protein
  • RGD1306908 protein
  • spdl1 protein
  • spdl1-a protein
  • SPINDLY protein

Protein level used designations for CCDC99

spindly , CG15415-PB , Spindly-PB , coiled-coil domain containing 99 , coiled-coil domain-containing protein 99 , protein Spindly , spindle apparatus coiled-coil domain-containing protein 1 , arsenite-related gene 1 protein , hSpindly , rhabdomyosarcoma antigen MU-RMS-40.4A , rrhabdomyosarcoma antigen protein MU-RMS-40.4A , spindly homolog , Coiled-coil domain-containing protein 99-A , protein Spindly-A , spindle apparatus coiled-coil domain-containing protein 1-A

GENE ID SPECIES
33578 Drosophila melanogaster
820327 Arabidopsis thaliana
100170491 Xenopus (Silurana) tropicalis
515158 Bos taurus
54908 Homo sapiens
70385 Mus musculus
303037 Rattus norvegicus
734358 Xenopus laevis
568360 Danio rerio
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