anti-Coiled-Coil and C2 Domain Containing 1A (CC2D1A) Antibodies

CC2D1A encodes a transcriptional repressor that binds to a conserved 14-bp 5'-repressor element and regulates expression of the 5-hydroxytryptamine (serotonin) receptor 1A gene in neuronal cells. Additionally we are shipping Coiled-Coil and C2 Domain Containing 1A Kits (17) and Coiled-Coil and C2 Domain Containing 1A Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CC2D1A 54862 Q6P1N0
CC2D1A 212139 Q8K1A6
CC2D1A 288908 Q66HA5
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Top anti-Coiled-Coil and C2 Domain Containing 1A Antibodies at antibodies-online.com

Showing 10 out of 61 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated EIA, WB CC2D1A Antibody (N-term) western blot analysis in K562 cell line lysates (35µg/lane).This demonstrates the CC2D1A antibody detected the CC2D1A protein (arrow). 0.4 mL 6 to 8 Days
$484.00
Details
Human Mouse Un-conjugated IF, IHC (p), WB Western Blot analysis of CC2D1A expression in transfected 293T cell line by CC2D1A MaxPab polyclonal antibody.Lane 1: CC2D1A transfected lysate(104.61 KDa).Lane 2: Non-transfected lysate. CC2D1A MaxPab polyclonal antibody. Western Blot analysis of CC2D1A expression in human liver. 50 μg 11 to 12 Days
$440.00
Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of various cells, using CC2D1A antibody. 100 μL 11 to 13 Days
$366.77
Details
Human Rabbit Un-conjugated WB Western blot analysis in K562 cell line lysates (35ug/lane). 400 μL 2 to 3 Days
$515.63
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of CC2D1A expression in Whole cell lysate from 293T cells ,The lane on the left is treated with the antigen-specific peptide. 100 μL 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated IP, WB CC2D1A MaxPab rabbit polyclonal antibody. Western Blot analysis of CC2D1A expression in human liver. Immunoprecipitation of CC2D1A transfected lysate using anti-CC2D1A MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead , and immunoblotted with CC2D1A MaxPab rabbit polyclonal antibody (D01) . 100 μL 11 to 12 Days
$425.71
Details
Human Rabbit Un-conjugated WB Western blot analysis of extracts of various cell lines, using CC2D1A antibody (ABIN5972761) at 1/1000 dilution. 100 μL 11 to 16 Days
$426.40
Details
Human Rabbit Un-conjugated IHC (p) Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human liver with CC2D1A polyclonal antibody  shows strong cytoplasmic positivity in hepatocytes at 1:50-1:200 dilution. 100 μL 11 to 12 Days
$577.33
Details
Human Rabbit Un-conjugated WB CC2D1A MaxPab rabbit polyclonal antibody. Western Blot analysis of CC2D1A expression in human liver. Western Blot analysis of CC2D1A expression in transfected 293T cell line by CC2D1A MaxPab polyclonal antibody.Lane 1: CC2D1A transfected lysate(104.10 KDa).Lane 2: Non-transfected lysate. 100 μg 11 to 12 Days
$425.71
Details
Human Mouse Un-conjugated IF, IHC, IHC (p), WB   50 μg 11 to 14 Days
$837.83
Details

Top referenced anti-Coiled-Coil and C2 Domain Containing 1A Antibodies

  1. Human Polyclonal CC2D1A Primary Antibody for ICC, IF - ABIN5665683 : Basel-Vanagaite, Attia, Yahav, Ferland, Anteki, Walsh, Olender, Straussberg, Magal, Taub, Drasinover, Alkelai, Bercovich, Rechavi, Simon, Shohat: The CC2D1A, a member of a new gene family with C2 domains, is involved in autosomal recessive non-syndromic mental retardation. in Journal of medical genetics 2006 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal CC2D1A Primary Antibody for IF, IHC (p) - ABIN527223 : Nakamura, Arai, Fujita: Centrosomal Aki1 and cohesin function in separase-regulated centriole disengagement. in The Journal of cell biology 2009 (PubMed)

More Antibodies against Coiled-Coil and C2 Domain Containing 1A Interaction Partners

Human Coiled-Coil and C2 Domain Containing 1A (CC2D1A) interaction partners

  1. Both expressions of CC2D1A and HTR1A genes studied on autism spectrum disorder cases and controls were significantly different

  2. CC2D1A binds to CHMP4B polymers formed on endosomes to regulate the endosomal sorting pathway.CC2D1A regulates degradation and signaling of EGFR and TLR4.

  3. Aki1 was expressed in human diffuse malignant mesothelioma specimens. Expression correlated with phosphorylated CREB1. Aki1 regulates CREB by modulating protein kinase A activity. The Aki1-CREB axis plays an important role in DMM pathogenesis.

  4. Null mutations in CC2D1A consistently cause a variable spectrum of presentations including ID, ASD, and seizures. CC2D1A regulates NF-kappaB signaling.

  5. All of the pancreatic cancer cell lines expressed Aki1. Silencing of Aki1 in Panc1 cells reduced the phosphorylation of Akt and increased the phosphorylation of cleaved PARP.

  6. Non-genomic downregulation of 5-HT1A receptor by 17betaestradiol does not involve NUDR and Freud-1 proteins.

  7. TBK1-associated protein in endolysosomes (TAPE)/CC2D1A is a key regulator linking RIG-I-like receptors to antiviral immunity

  8. CHMP4B interacts directly with CC2D1A and CC2D1B with nanomolar affinity by forming a 1:1 complex.

  9. CC2D1A interaction with CHMP4B/4A blocks HIV-1 budding.

  10. Results suggest the involvement of CC2D1A and CC2D2A in mental retardation in the Han Chinese population, and some specific haplotypes may be susceptible or protective.

  11. Reductions in Freud-1 expression in prefrontal cortex may be associated with early onset of major depressive disorder.

  12. Data suggest that the anti-tumor activity of NF-kappaB inhibitors is associated with p53-mediated activation of autophagy.

  13. central role for TAPE (CC2D1A/Freud-1/Aki-1)in linking TLR3 and TLR4 to innate immune defenses at an early step

  14. CC2D1A activates NF-kappaB through the canonical IKK pathway

  15. these results indicate that cyclin B1-Cdk1 is a kinase of Aki1 during mitosis and that its phosphorylation of Aki1 may regulate mitotic function.

  16. Centrosome-associated Aki1 and cohesin play pivotal roles in preventing premature cleavage in centriole cohesion.

  17. A protein truncating mutation was identified in the gene CC2D1A in nine consanguineous families with severe autosomal recessive mental retardation.

  18. a deletion in the CC2D1A gene has been linked to nonsyndromic mental retardation. This deletion results in the truncation of the helix-loop-helix DNA binding and the C2 domains.

  19. Freud-1 has a key role in regulating DRD2 expression

  20. disruption of transcriptional regulation by mutation of Freud-1 may play a role in abnormal brain function leading to mental retardation

Mouse (Murine) Coiled-Coil and C2 Domain Containing 1A (CC2D1A) interaction partners

  1. Cc2d1a conditional knockout mice therefore recapitulate features of both cognitive and social impairment caused by human CC2D1A mutation

  2. Freud-1 is crucial for 5-HT1A autoreceptor expression and links up-regulation of 5-HT1A autoreceptors to anxiety/depression-like behavior.

  3. CC2D1A and CC2D1B role and function in the endocytic pathway and Notch signalling.

  4. TBK1-associated protein in endolysosomes (TAPE)/CC2D1A is a key regulator linking RIG-I-like receptors to antiviral immunity

  5. Cc2d1a is required for mouse survival and performs essential function in controlling functional maturation of synapses.

  6. Freud-1, is involved in the compensatory mechanisms that modulate the functional state of brain serotonin system, although it is not the only factor for 5-HT(1A) receptor transcriptional regulation.

  7. Freud-1 has a key role in regulating DRD2 expression

  8. Paper describes a function of Cc2d1a/Cc2d1b and its Drosophila homologue l(2)gd in D.melanogaster in Notch trafficking.

  9. Novel calcium-regulated repressor that negatively regulates basal 5-HT1A receptor expression.

Coiled-Coil and C2 Domain Containing 1A (CC2D1A) Antigen Profile

Protein Summary

This gene encodes a transcriptional repressor that binds to a conserved 14-bp 5'-repressor element and regulates expression of the 5-hydroxytryptamine (serotonin) receptor 1A gene in neuronal cells. The DNA binding and transcriptional repressor activities of the protein are inhibited by calcium. A mutation in this gene results in nonsyndromic mental retardation-3.

Gene names and symbols associated with CC2D1A

  • coiled-coil and C2 domain containing 1A (CC2D1A) antibody
  • coiled-coil and C2 domain containing 1A (cc2d1a) antibody
  • coiled-coil and C2 domain containing 1A (Cc2d1a) antibody
  • BC016188 antibody
  • Freud-1 antibody
  • Freud-1/Aki1 antibody
  • MRT3 antibody
  • RGD1306108 antibody
  • Tape antibody

Protein level used designations for CC2D1A

coiled-coil and C2 domain containing 1A , coiled-coil and C2 domain-containing protein 1A , coiled-coil and C2 domain-containing protein 1A-like , Akt kinase-interacting protein 1 , FRE under dual repression-binding protein 1 , five prime repressor element under dual repression-binding protein 1 , five repressor element under dual repression-binding protein 1 , mental retardation, nonsyndromic, autosomal recessive, 3 , putative NF-kappa-B-activating protein 023N , putative NFkB activating protein , 5-HT1A receptor , five' repressor element under dual repression binding protein 1 , freud-1

GENE ID SPECIES
468744 Pan troglodytes
484911 Canis lupus familiaris
513078 Bos taurus
718483 Macaca mulatta
100020918 Monodelphis domestica
100145460 Xenopus (Silurana) tropicalis
100482182 Ailuropoda melanoleuca
100603711 Nomascus leucogenys
54862 Homo sapiens
212139 Mus musculus
288908 Rattus norvegicus
100712639 Cavia porcellus
101119902 Ovis aries
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