Collagen, Type IX, alpha 1 Proteins (COL9A1)

COL9A1 encodes one of the three alpha chains of type IX collagen, which is a minor (5-20%) collagen component of hyaline cartilage. Additionally we are shipping COL9A1 Antibodies (50) and COL9A1 Kits (25) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
COL9A1 1297 P20849
Mouse COL9A1 COL9A1 12839 Q05722
COL9A1 305104  
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Top COL9A1 Proteins at

Showing 6 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Human Cells Human Fc Tag 100 μg Log in to see 20 to 21 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
Human Cells Human His tag   10 μg Log in to see 15 to 16 Days
Escherichia coli (E. coli) Rat Un-conjugated SDS-PAGE analysis of Rat COL9a1 Protein. 100 μg Log in to see 11 to 18 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days

COL9A1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Rat (Rattus) ,

More Proteins for Collagen, Type IX, alpha 1 (COL9A1) Interaction Partners

Zebrafish Collagen, Type IX, alpha 1 (COL9A1) interaction partners

Human Collagen, Type IX, alpha 1 (COL9A1) interaction partners

  1. the COL9A1 rs35470562 variant may contribute to congenital talipes equinovarus susceptibility in the Chinese population examined.

  2. We observed a significant association between rs6910140 of COL9A1 and KBD, suggesting a role of COL9A1 in the development of KBD.

  3. The study demonstrated that hypermethylation is associated with down-regulation of COL9A1 expression in osteoarthritic (OA) cartilage and highlights the pivotal role of epigenetics in OA.

  4. The NC2 (show GTF2H5 Proteins) domain of type IX collagen determines the chain composition but also the chain register of the triple helix.

  5. Type IX collagen interacts with fibronectin (show FN1 Proteins) providing an important molecular bridge in articular cartilage

  6. A second, novel mutation was identified in COL9A1, causing autosomal recessive Stickler syndrome together with the previously described nucleotide change in two separate families.

  7. COL9A1 protein is highly expressed in patients with idiopathic congenital talipes equinovarus (ICTEV) and rs1135056, which is located in the coding region of COL9A1 gene, may be associated with the pathogenesis of ICTEV.

  8. NC2 (show GTF2H5 Proteins) domain of collagen IX provides chain selection and heterotrimerization

  9. Data show that the proximal-promoter region of the human COL9A1 gene can drive expression of a reporter gene in chondrocytic RCS (show ARPP21 Proteins) cells, but not in nonchondrocytic cell lines.

  10. the amino-terminal NC4 domain of human collagen IX interacts with glycosaminoglycans and cartilage oligomeric matrix protein (show COMP Proteins)

Mouse (Murine) Collagen, Type IX, alpha 1 (COL9A1) interaction partners

  1. An accelerated hypertrophic differentiation caused by a disturbed Ihh (show IHH Proteins)-PTHrP signaling pathway may lead to a higher bone mineral density in the vertebral bodies of newborn Col (show HDAC1 Proteins) IX -/- mice and, as a result, to the early onset of disc degeneration.

  2. Results show that absence of Col (show HDAC1 Proteins) IX induces early developmental, structural and biomechanical alterations in both vertebral body and intervertebral disc which eventually cause severe degenerative changes in the aging spine.

  3. They test the hypothesis that aged Col9a1(-/-) mice would reduce joint pain by adopting locomotor behaviors that reduce both the magnitude and daily frequency of joint loading.

  4. Loss of type IX collagen and COMP (show COMP Proteins) leads to matrix aberrations that may make cartilage more susceptible to degeneration.

  5. all long bones are shorter and broader in newborn Col9a1-/- mice

  6. Col9a1(-/-) mice present behavioral changes consistent with anatomic signs of osteoarthritis and intervertebral disc degeneration.

COL9A1 Protein Profile

Protein Summary

This gene encodes one of the three alpha chains of type IX collagen, which is a minor (5-20%) collagen component of hyaline cartilage. Type IX collagen is usually found in tissues containing type II collagen, a fibrillar collagen. Studies in knockout mice have shown that synthesis of the alpha 1 chain is essential for assembly of type IX collagen molecules, a heterotrimeric molecule, and that lack of type IX collagen is associated with early onset osteoarthritis. Mutations in this gene are associated with osteoarthritis in humans, with multiple epiphyseal dysplasia, 6, a form of chondrodysplasia, and with Stickler syndrome, a disease characterized by ophthalmic, orofacial, articular, and auditory defects. Two transcript variants that encode different isoforms have been identified for this gene.

Gene names and symbols associated with COL9A1

  • collagen, type IX, alpha 1b (col9a1b)
  • collagen, type IX, alpha 1 L homeolog (col9a1.L)
  • collagen type IX alpha 1 chain (COL9A1)
  • collagen, type IX, alpha 1 (Col9a1)
  • collagen type IX alpha 1 chain (Col9a1)
  • collagen alpha-1(IX) chain (LOC101102992)
  • cb339 protein
  • Col9a-1 protein
  • DJ149L1.1.2 protein
  • EDM6 protein
  • MED protein
  • MGC82441 protein
  • sb:cb339 protein
  • STL4 protein
  • wu:fa12a12 protein
  • wu:fa12d02 protein
  • wu:fc22c08 protein
  • wu:fc38d08 protein
  • zgc:85892 protein

Protein level used designations for COL9A1

collagen type IX alpha I , collagen, type IX, alpha 1 , alpha 1 type IX collagen , collagen alpha-1(IX) chain-like , alpha-1(IX) collagen chain , cartilage-specific short collagen , collagen IX, alpha-1 polypeptide , collagen alpha-1(IX) chain , procollagen, type IX, alpha 1 , alpha(IX) collagen-proteoglycan , cartilage alpha(IX) collagen

406548 Danio rerio
446631 Xenopus laevis
462810 Pan troglodytes
100446946 Pongo abelii
100601529 Nomascus leucogenys
1297 Homo sapiens
12839 Mus musculus
100723407 Cavia porcellus
100155319 Sus scrofa
305104 Rattus norvegicus
771873 Gallus gallus
481873 Canis lupus familiaris
282195 Bos taurus
101102992 Ovis aries
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