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COL12A1 encodes the alpha chain of type XII collagen, a member of the FACIT (fibril-associated collagens with interrupted triple helices) collagen family. Additionally we are shipping COL12A1 Antibodies (30) and and many more products for this protein.
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Certain core genes, including COL12A1, glutathione Stransferase alpha3 (GSTA3), fibrinogen alpha chain (FGA) and fibrinogen gamma chain (FGG), were the first reported to be associated with Gastric Cancer. Survival analysis suggested that these four genes, COL12A1 (P=0.002), GSTA3 (P=3.4x106), FGA (P=0.00075) and FGG (P=1.4x105), were significant poor prognostic factors of gastric cancer.
In conclusion, the novel main finding of this study was a significant interaction between the COL5A1 rs12722 T/C and COL12A1 rs970547 A/G variants and risk of anterior cruciate ligament injury.
Extracellular matrix proteins expression profiling in chemoresistant variants of the A2780 ovarian cancer cell line.
The study indicates that the spectrum of causative genes in extracellular matrix-related myopathies be extended to include COL12A1.
collagen alpha-1 (XII) chain was expressed at dramatically higher (~10-fold) levels in breast
results show that this gene interacts collagen x1 encoded genes to modulate the risk for AT
COL3A1 rs1800255, COL6A1 rs35796750 and COL12A1 rs970547 were not significantly associated with sit-and-reach, straight leg raise or total shoulder rotation range of motion
Type XII collagen is overexpressed in permanent human and mouse corneal scars and could represent a new target to treat corneal scarring.
In addition to binding collagen I, COMP binds to collagens XII and XIV via their C-terminal collagenous domains.
COL12A1 is associated with anterior cruciate ligament ruptures among females
this study identifies COL12A1 as the likely gene candidate within the recurrent 6q13 breakpoint and provides an alternative approach for detecting 6q13 anomalies in nondividing cells of chondromyxoid fibroma.
induction of expression by sheare stress is associated with atherogenesis
Results suggest that collagens XII and XIV might serve different functions during human embryonic development although their structures are highly similar.
both COL12A1 and COL4A5 constitute good candidate target genes in the pathogenesis of subungual exostosis
These data demonstrate, for the first time, a functional relationship between collagens VI and XII during osteogenesis.
data demonstrate important regulatory roles for type XII collagen in osteoblast differentiation and bone matrix formation
new information on the mechanical strain-mediated transcriptional control of alpha 1(XII)-mediated fibrillogenesis in the bone.
Wnt/beta-catenin signaling induces expression of col12a1a/b and deposition of Collagen XII, which is necessary for axons to actively navigate the non-neural lesion site environment.
collagen XII is implicated in tissue cohesion by stabilizing fascia and by linking fascia to basement membranes
This gene encodes the alpha chain of type XII collagen, a member of the FACIT (fibril-associated collagens with interrupted triple helices) collagen family. Type XII collagen is a homotrimer found in association with type I collagen, an association that is thought to modify the interactions between collagen I fibrils and the surrounding matrix. Alternatively spliced transcript variants encoding different isoforms have been identified.
collagen alpha-1(XII) chain
, collagen type XII proteoglycan
, procollagen, type XII, alpha 1
, collagen XII
, collagen type XII alpha 1 chain
, collagen, type XII, alpha 1
, type XII collagen alpha 1 chain
, collagen alpha-1(XII) chain-like
, type XII collagen