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CRMP1 encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system.
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Human Polyclonal CRMP1 Primary Antibody for WB - ABIN550348
Cameron, McKay: Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus. in The Journal of comparative neurology 2001
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Study shows that CRMP1 acts an EMT and metastasis suppressor in prostate cancer cells via its regulation of actin polymerization.
Identify CRMP-1 as a novel regulator of actin filament elongation and reveal a surprisingly important role for CRMP-1, EVL, and actin polymerization in maintaining the structural integrity of epithelial sheets.
The present study reports that miR (show MLXIP Antibodies)-187 was significantly overexpressed in gastric cancer tissues compared to that in non-tumor tissues and was associated with malignant clinical factors such as depth of invasion (P = 0.005), tumor size (P = 0.024), lymph node metastasis . It was found that collapsin response mediator protein 1 (CRMP1), a tumor suppressor, was a direct downstream target of miR (show MLXIP Antibodies)-187.
miR200a-3p promotes the proliferation of human esophageal cancer cells by post-transcriptionally regulating CRMP1.
CRMP1 interacted with Spy1 (show SPDYA Antibodies) which would disturb the association of CRMP1 with actin and was involved in the collapse of growth cones induced by Sema3A (show SEMA3A Antibodies) and regeneration after sciatic nerve crush.
These results demonstrate an important role for CRMP-1 in Listeria actin comet tail formation and open the possibility that CRMP-1 controls cell motility by modulating Arp2 (show ACTR2 Antibodies)/3 activation.
Human CRMP-1 comprises a tetrameric assembly.
Results show that expression of CRMP1 is downregulated in medulloblastoma (MB) tumors. its overexpression inhibits proliferation, migration and invasion of cells suggesting that CRMP1 is implicated in MB pathogenesis.
Aberrant upregulation of CRMP-1 expression may link to the mechanism of developing early-onset preeclampsia.
CRMP1 targets aggregation-prone, N-terminal HTT (show HTT Antibodies) fragments and suppresses their spontaneous self-assembly.
Results indicate that CRMP1 and CRMP4 (show DPYSL3 Antibodies) regulate proper orientation of the basal dendrites of layer V neurons in the cerebral cortex during development.
this paper shows that Nav1.7 (show SCN9A Antibodies), by coupling with CRMP1, mediates the axonal retrograde signaling of Sema3A (show SEMA3A Antibodies) in axonal guidance
We generated CRMP2 (show DPYSL2 Antibodies) gene-deficient (crmp2 (show DPYSL2 Antibodies)(-/-) ) mice. The crmp2 (show DPYSL2 Antibodies)(-/-) mice showed irregular development of dendritic spines in cortical neurons. The level of CRMP1 was increased in crmp2 (show DPYSL2 Antibodies)(-/-) , but the level of CRMP2 (show DPYSL2 Antibodies) was not altered in crmp1(-/-).The phenotypic defects had no genetic interaction between crmp1 and crmp2 (show DPYSL2 Antibodies).
LCRMP (show DPYSL3 Antibodies)-1 and CRMP-1 have opposing functions in regulating cancer cell invasion and metastasis
Data demonstrate that CRMP1 tyrosine 504 is a primary target of the Src (show SRC Antibodies) family of tyrosine kinases (SFKs), specifically Fyn (show FYN Antibodies).
Data link the reduction in PMCA2 (show ATP2B2 Antibodies) expression with perturbations in CRMP1 expression and death of spinal cord neurons, representing an additional mechanism underlying AMPA (show GRIA3 Antibodies)/kainate receptor-mediated excitotoxicity with relevance to neurodegeneration in EAE.
The structural bases for Crmp1 function in plexin-dependent sempahorin3A signaling were studied.
In the olfactory bulb, CRMP1, CRMP2 (show DPYSL2 Antibodies) and CRMP5 (show DPYSL5 Antibodies) are abundant in neuronal progenitors of the subependymal layer and in differentiating interneurons.
Mice lacking Crmp1 showed a decrease in the number of granule cells migrating out of explants of developing cerebellum.
Collapsin response mediator protein 1 (CRMP1)regulates neuronal migration by mediating Reelin (show RELN Antibodies) signaling.
Crmp1 is expressed in numerous sites in the developing nervous system
This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants.
collapsin response mediator protein 1
, cysteine repeat modular protein 1, putative
, dihydropyrimidinase related protein-1
, dihydropyrimidinase-like 1
, dihydropyrimidinase-related protein 1
, unc-33-like phosphoprotein 3
, collapsin response mediator protein-1B