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COLEC10 encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. Additionally we are shipping COLEC10 Kits (30) and COLEC10 Proteins (11) and many more products for this protein.
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During acute-phase responses, the CL-L1 levels display only minor variations. In serum, CL-L1 was found in complexes with mannan-binding lectin-associated serine proteases, suggesting a role in the lectin pathway of complement activation.
mouse collectin liver 1 gene, Cll1 was found on chromosome 15 in a region syntenic with human chromosome 8q
High CLL1 expression is associated with cardiovascular disease.
Exome sequencing reveals mutations in collectin sub-family member 10 (C-type lectin) protein (COLEC10) as a cause of 3MC syndrome with main features include facial dysmorphism, craniosynostosis and cleft lip/palate.
high serum CL-L1 concentration in critically ill children upon PICU admission is associated with an increased risk of infection and prolonged need of intensive care, and counteracts the protective effect of having a high MASP-3 concentration
Data indicate differences in the plasma concentrations of collectin liver 1 and collectin kidney 1, M-ficolin and H-ficol in systemic lupus erythematosus (SLE) patients compared to a group of healthy controls.
Carriers of COLEC10 Arg125Trp had increased CL-L1 serum levels.
Most plasma CL-K1 was found in complex with CL-L1 in a ratio suggesting a heteromeric subunit of 1 CL-L1 & 2 CL-K1 polypeptides.
This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. The other members of this family are secreted proteins and bind to carbohydrate antigens on microorganisms facilitating their recognition and removal. This gene product is a cytosolic protein, a characteristic that suggests that it may have different biological functions than other C-lectins.
collectin sub-family member 10 (C-type lectin)
, collectin liver 1
, collectin liver protein 1
, collectin 34
, collectin 1