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CNTNAP4 product belongs to the neurexin family, members of which function in the vertebrate nervous system as cell adhesion molecules and receptors.
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This study is the first demonstration for association of the CNTNAP4 gene and one of its intronic CNV polymorphisms with aging.
A quantitative analysis of central corneal thickness and a subsequent analysis of primary open-angle glaucoma (POAG), SNPs in two cell adhesion molecules, NTM (show NTM Proteins) and CNTNAP4, were identified and may increase POAG susceptibility in a subset of cases.
Caspr4 inhibits neuronal differentiation in a LNX (show LNX1 Proteins)-dependent manner.
Cntnap4 is localized presynaptically and its loss leads to a reduction in the output of cortical parvalbumin (PV (show PVALB Proteins))-positive GABAergic (gamma-aminobutyric acid producing) basket cells.
This gene product belongs to the neurexin family, members of which function in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, and thrombospondin N-terminal-like domains. Alternative splicing results in two transcript variants encoding different isoforms.
contactin associated protein-like 4
, cell recognition protein CASPR4
, contactin associated protein-like 5
, contactin-associated protein-like 4
, contactin associated protein 4
, contactin-associated protein-like 4-like
, cell recognition molecule Caspr4