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In acute myeloid leukemia, especially in the M2 subtype, the t(8\;21)(q22\;q22) translocation is one of the most frequent karyotypic abnormalities. Additionally we are shipping Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 Antibodies (91) and many more products for this protein.
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In acute myeloid leukemia, especially in the M2 subtype, the t(8\;21)(q22\;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.
translocated to, 2
, myeloid translocation gene-related protein 1
, protein CBFA2T2
, CBFA2T2 identified gene homolog
, MTG8-like protein
, MTG8-related protein 1
, core-binding factor runt domain alpha subunit 2 translocated to 2 homolog
, core-binding factor, runt domain, alpha subunit 2, translocated to, 2 homolog
, ETO homolog on chromosome 20
, ETO homologous on chromosome 20
, myeloid translocation-related protein 1
, a subunit 2; translocated to, 2
, expressed during neurogenesis