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CBFA2T2 Products

(Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2))

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In acute myeloid leukemia, especially in the M2 subtype, the t(8\;21)(q22\;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008].

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Featured CBFA2T2 Categories

CBFA2T2 Antibodies

High quality antibodies with extensive validation data.

CBFA2T2 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended CBFA2T2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application IHC (p), ELISA, WB
Validations
  • (4)
Cat. No. ABIN522603
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application DB, ICC, FACS, WB
Validations
  • (3)
Cat. No. ABIN930909
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (3)
Cat. No. ABIN522600
Quantity 100 μg
Datasheet Datasheet

Recommended CBFA2T2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3131988
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3093949
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1348157
Quantity 2 μg
Datasheet Datasheet

Latest Publications for our CBFA2T2 products

Meier, Krpic, Rodriguez, Strouboulis, Monti, Krijgsveld, Gering, Patient, Hostert, Grosveld: "Novel binding partners of Ldb1 are required for haematopoietic development." in: Development (Cambridge, England), Vol. 133, Issue 24, pp. 4913-23, (2006) (PubMed).

Synonyms and alternative names related to CBFA2T2

CBFA2/RUNX1 translocation partner 2 (Cbfa2t2), CBFA2/RUNX1 translocation partner 2 (CBFA2T2), core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human) (Cbfa2t2), CBFA2/RUNX1 translocation partner 2 L homeolog (cbfa2t2.L), A430091M07, C330013D05Rik, cbfa2t2-a, Cbfa2t2h, EHT, MTGR1, p85, XETOR, ZMYND3

Protein level used designations for CBFA2T2

  • translocated to, 2
  • myeloid translocation gene-related protein 1
  • protein CBFA2T2
  • CBFA2T2 identified gene homolog
  • MTG8-like protein
  • MTG8-related protein 1
  • core-binding factor runt domain alpha subunit 2 translocated to 2 homolog
  • core-binding factor, runt domain, alpha subunit 2, translocated to, 2 homolog
  • ETO homolog on chromosome 20
  • ETO homologous on chromosome 20
  • myeloid translocation-related protein 1
  • a subunit 2; translocated to, 2
  • expressed during neurogenesis
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