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Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. Additionally we are shipping CKMT1A Antibodies (67) and CKMT1A Proteins (9) and many more products for this protein.
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Mitochondrial creatine kinase CKMT1 is necessary for survival of EVI1-expressing cells in subjects with EVI1-positive AML.
CKMT1 is a key regulator of the permeability transition pore through a complex that is distinct from the classical permeability transition pore.
the knock-down of the mitochondrial creatine kinase-1 (CKMT1) by RNA interference causes the dissipation of the mitochondrial membrane potential
ASB9 interacts with the creatine kinase system and negatively regulates cell growth.
MtCK, but not NDPK-D, shows some specificity in the nature of the lipids transferred and it is not active with phosphatidylcholine alone
uMtCK in prostate neoplasm cells (LNCaP) contributes to overproduction of reactive oxygen species, activation of Akt signaling pathway and more aggressive phenotypes including androgen independence development.
Hypothalamic plasticity of neuropeptide Y is lacking in brain-type creatine kinase double knockout mice with defective thermoregulation
mitochondrial creatine kinase expression in hepatocellular carcinoma may be caused by hepatocarcinogenesis per se but not by loss of mitochondrial integrity, of which ASB9 could be a negative regulator
UbCKmit was expressed selectively in neurons and localized in their mitochondria in dendrites, cell bodies
Brain type and mitochondrial ubiquitous CK double knockout mice have a reduced body weight, and demonstrate a severely impaired spatial learning in both a dry and a wet maze, lower nestbuilding activity and diminished acoustic startle reflex responses.
Data suggest that amyloid precursor protein may regulate cellular energy levels and mitochondrial function via a direct interaction and stabilization of ubiquitous mitochondrial creatine kinase.
Mt-CK(-/-) on a C57BL/6 background do not develop LV hypertrophy or dysfunction even up to 1 year, and this may be explained by a compensatory increase in MM-CK activity and mitochondrial volume
Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase\; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins.
, acidic-type mitochondrial creatine kinase
, creatine kinase U-type, mitochondrial
, creatine kinase, mitochondrial 1 (ubiquitous)
, ubiquitous mitochondrial creatine kinase
, creatine kinase, mitochondrial 1A
, creatine kinase, ubiquitous mitochondrial
, creatine kinase, mitochondrial 1, ubiquitous
, creatine kinase, mitochondrial 1B
, Acidic-type mitochondrial creatine kinase
, Ubiquitous mitochondrial creatine kinase
, mitochondrial creatine kinase 1B