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Crystallins are the dominant structural components of the vertebrate eye lens.. Additionally we are shipping Crystallin, beta A1 Antibodies (52) and Crystallin, beta A1 Kits (4) and many more products for this protein.
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We identified a de novo in-frame 3-bp deletion in the proband with an autosomal dominant congenital cataract, but not in her parents, in an Iranian family. This mutation has occurred de novo on a paternal gamete during spermatogenesis. The in-silico results predicted the interaction of CRYBA1 protein with the other CRY (show CRY2 Proteins) as well as proteins responsible for eye cell signaling.
association between a frameshift mutation in exon 6 of CRYBA1/A3 and congenital cataracts
Data indicate that alpha-crystallin B chain (show CRYAB Proteins) and beta-crystallin A3-cyrstallins dissociate to the monomers upon racemization of d-aspartic acids (Asp (show ASIP Proteins)).
A novel splice site mutation in CRYBA1/A3 is associated with autosomal dominant nuclear cataracts in a Chinese family.
A splice site mutation (c.215+1G>A) at the first base of intron 3 of the crystallin beta A3/A1 (CRYBA3/A1) gene has been identified in Chinese congenital polymorphic cataract patients.
ThebetaA3-crystallin and betaB1-crystallin (show CRYBB1 Proteins) homomers and the betaA3/betaB1-crystallin (show CRYBB1 Proteins) heteromer all undergo similar five-state folding pathways which include one dimeric and two monomeric intermediates.
A G-->T splice site mutation of CRYBA1/A3 associated with autosomal dominant suture cataracts in a Chinese family.
The c.279-281delGAG mutation in CRYBA1 is responsible for the autosomal dominant congenital nuclear cataract disease in this Chinese family.
This is the first report of a phenotype of progressive nuclear and cortical cataracts related to the CRYBA3/A1 mutation IVS3+1 G>A.
This study is the first report relating a mutation of CRYBA1/A3 to posterior polar cataract.
CRYbetaA3/A1-crystallin has a role in preventing nuclear cataract impaired lysosomal cargo clearance and calpain activation
Data suggest a mechanism by which betaA3/A1-crystallin regulates lysosomal function by modulating the activity of V-ATPase (show ATP6V1H Proteins).
Data show that betaA3/A1-crystallin affects the signal transducer and activator of transcription 3 (STAT3 (show STAT3 Proteins)) activation in optic nerve astrocytes.
loss of CRYBA1 causes lysosomal dysregulation leading to the impairment of both autophagy and phagocytosis
p53 (show TP53 Proteins) can regulate lens differentiation by controlling expression of the differentiation genes coding for the lens crystallins.
The thermodynamic consequences of the loss of beta A3-crystallin terminal extensions by in vivo proteolytic processing could increase their tendency to associate and so promote the formation of higher order associates in the aging and cataractous lens.
Results show that both betaB2- and betaA3-crystallin bind calcium with moderate affinity.
Crystallins are the dominant structural components of the vertebrate eye lens.
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, lens structural protein
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