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The protein encoded by CCNK is a member of the transcription cyclin family. Additionally we are shipping Cyclin K Kits (12) and Cyclin K Proteins (5) and many more products for this protein.
Showing 10 out of 64 products:
Human Monoclonal Cyclin K Primary Antibody for RNAi, ELISA - ABIN563802
Dowejko, Bauer, Bauer, Müller-Richter, Reichert: The human HECA interacts with cyclins and CDKs to antagonize Wnt-mediated proliferation and chemoresistance of head and neck cancer cells. in Experimental cell research 2012
Human Polyclonal Cyclin K Primary Antibody for ICC, IF - ABIN438465
Ekumi, Paculova, Lenasi, Pospichalova, Bösken, Rybarikova, Bryja, Geyer, Blazek, Barboric: Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex. in Nucleic acids research 2015
Cyclin K regulates prereplicative complex assembly to promote mammalian cell proliferation
Structures of CDK12 (show CRKRS Antibodies)/CycK complexes solved in the presence of AMP (show APRT Antibodies)-PNP (show NP Antibodies).
Data show that most mutations prevent formation of the cyclin-dependent kinase 12 (Cdk12 (show CRKRS Antibodies))/cyclin K (CycK) complex, rendering the kinase inactive.
Cyclin K is highly expressed in mammalian testes in a developmentally regulated manner.
Cyclin K interacts with CDK12 and CDK13 but not CDK9 in cells, and is required to maintain self-renewal in ES cells.
Cyclin (show PCNA Antibodies) K1 is the primary cyclin (show PCNA Antibodies) partner for CDK12/CrkRS (show CRKRS Antibodies) and it is required for activation of CDK12/CrkRS (show CRKRS Antibodies) to phosphorylate the C-terminal domain of RNA Pol II (show Pol II Antibodies).
Cyclin K inhibits HIV-1 gene expression and replication by interfering with cyclin-dependent kinase 9 (CDK9 (show CDK9 Antibodies))-cyclin T1 (show CCNT1 Antibodies) interaction in Nef-dependent manner.
These results reveal an unexpectedly direct role for CDK9 (show CDK9 Antibodies)-cyclin K in checkpoint pathways that maintain genome integrity in response to replication stress.
Cyclin K-expressing multiple myeloma LP-1 (show RPLP1 Antibodies) cells have lost their migration properties and display enhanced clonogenic capacities
P-TEFb (show CCNT1 Antibodies) containing cyclin K and Cdk9 (show CDK9 Antibodies) can activate transcription via RNA.
that cyclin K may be a novel molecular link between germ cell development, cancer development and embryonic stem cell maintenance.
Cyclin K-containing kinase complexes maintain self-renewal in murine embryonic stem cells.
The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities.
, cyclin K
, cyclin k