anti-Cyclin T1 (CCNT1) Antibodies

CCNT1 encodes a member of the highly conserved cyclin C subfamily. Additionally we are shipping Cyclin T1 Kits (12) and Cyclin T1 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CCNT1 904 O60563
CCNT1 12455 Q9QWV9
CCNT1 315291  
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Top anti-Cyclin T1 Antibodies at

Showing 10 out of 62 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
Human Rabbit Un-conjugated EIA, FACS, IHC (p), WB <span>CCNT1 Antibody (Center) flow cytometric analysis of MCF-7 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.</span> <span>CCNT1 Antibody (Center) western blot analysis in K562 cell line lysates (35µg/lane).This demonstrates the CCNT1 antibody detected the CCNT1 protein (arrow).</span> 0.4 mL Log in to see 6 to 8 Days
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-CCNT1 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:1562500<br><b>Positive Control: </b>721_B cell lysate 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated FACS, WB CCNT1 Antibody (Center) (ABIN654626) flow cytometric analysis of MCF-7 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Log in to see 10 to 11 Days
Human Rabbit Un-conjugated IHC (p), WB   100 μg Log in to see 4 to 6 Days
Bat Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
Human Rabbit Un-conjugated EIA, IHC (fro), IHC (p), IP, WB   0.1 mL Log in to see 12 to 15 Days
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 16 Days
Human Rabbit Un-conjugated IP, IHC, ELISA, WB Amino acids are numbered on the bottom of each protein. The cyclin box is indicated. Human cyclins T2a and T2b have 642 amino acids in common but different carboxyl termini (black boxes). Background Information:  Cyclin T1, together with the kinase CDK9, is a component of the transcription elongation factor P-TEFb which binds the human immunodeficiency virus type 1 (HIV-1) transactivator Tat. Tat stimulates human HIV-1 viral transcription elongation.  This suggests that cyclin T1/cdk9(PITALRE) is one of the HIV-1 required host cellular cofactors generated during T cell activation. Cyclin T1/cdk9(PITALRE) is shown to interact with Tat to restore Tat activation in HeLa nuclear extracts depleted of P-TEFb.   P-TEFb facilitates transcription by phosphorylating the carboxy-terminal domain (CTD) of RNA polymerase II. The cdk9(PITALRE) activity and cyclin T1 are essential for activation of transcription when tethered to the heterologous Rev response element RNA via the regulator of expression of virion Rev.  Cyclin T1 is an exceptionally large cyclin and is therefore a candidate for interactions with regulatory proteins. Anti-Cyclin T1 antibody was diluted 1:500 to detect Cyclin T1 in human skin tissue. Tissue was formalin fixed and paraffin embedded. No pre-treatment of sample was required. The image shows the localization of antibody as the precipitated red signal, with a hematoxylin purple nuclear counter stain. 100 μL Log in to see 1 to 2 Days
Human Rabbit Un-conjugated IHC (p), IP, ELISA, WB Human Skin (formalin-fixed, paraffin-embedded) stained with CCNT1 antibody ABIN218501 at 1:500 followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μL Log in to see 7 to 9 Days

CCNT1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human ,
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Mouse (Murine) ,

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Rat (Rattus) ,

Top referenced anti-Cyclin T1 Antibodies

  1. Cow (Bovine) Polyclonal Cyclin T1 Primary Antibody for WB - ABIN2792158 : Sun, Zheng, Zhao, Lee, Goldstein: Increased in vivo activation of microglia and astrocytes in the brains of mice transgenic for an infectious R5 human immunodeficiency virus type 1 provirus and for CD4-specific expression of human cyclin T1 in response to stimulation by lipopolysaccharide in Journal of virology 2008 (PubMed)

  2. Human Polyclonal Cyclin T1 Primary Antibody for EIA, FACS - ABIN951765 : Moiola, De Luca, Gardner, Vazquez, De Siervi: Cyclin T1 overexpression induces malignant transformation and tumor growth. in Cell cycle (Georgetown, Tex.) 2010 (PubMed)
    Show all 5 Pubmed References

More Antibodies against Cyclin T1 Interaction Partners

Fruit Fly (Drosophila melanogaster) Cyclin T1 (CCNT1) interaction partners

  1. We conclude that a subset of non-paused, pre-cellular genes are among the most susceptible to reduced P-TEFb (show CDK9 Antibodies), SEC and Mediator levels in Drosophila embryos.

  2. following P-TEFb (show CDK9 Antibodies) inhibition, most polymerases were restricted to within 150 bp of the transcription initiation site of the active Drosophila melanogaster Hsp70 gene, and live-cell imaging demonstrated that these polymerases were stably associated

Human Cyclin T1 (CCNT1) interaction partners

  1. ASF/SF2 (show SRSF1 Antibodies) is identified as a splicing regulator (show PTBP2 Antibodies) of cyclin T1, which contributes to the control of the subsequent transcription events.

  2. The TAR (show RBM8A Antibodies) central loop contacts the CycT1 Tat (show TAT Antibodies)-TAR (show RBM8A Antibodies) recognition motif (TRM) and the second Tat (show TAT Antibodies) Zn(2+)-binding loop. Hydrogen-deuterium exchange (HDX) shows that AFF4 (show AFF4 Antibodies) helix 2 is stabilized in the TAR (show RBM8A Antibodies) complex despite not touching the RNA, explaining how it enhances TAR (show RBM8A Antibodies) binding to the SEC 50-fold.

  3. Quantitative measurement of the molecular interactions among Tat (show TAT Antibodies), CycT1 and CDK9 (show CDK9 Antibodies) has showed that any third molecule enhances the binding between the other two molecules. These findings suggest that each component of the Tat:P-TEFb (show TEF Antibodies) complex stabilizes the overall complex, thereby supporting the efficient transcriptional elongation during viral RNA synthesis.

  4. the introduction of HIV-1 Tat (show TAT Antibodies) and Mg12+ ion resulted in the active site architectural characteristics of phosphorylated CDK9 (show CDK9 Antibodies)/cyclin T1 complex

  5. AFF4 (show AFF4 Antibodies) is positioned to make unexpected direct contacts with HIV Tat (show TAT Antibodies), and Tat (show TAT Antibodies) enhances P-TEFb/CCNT1 affinity for AFF4 (show AFF4 Antibodies).

  6. Plk1 (show PLK1 Antibodies) negatively regulates the RNA polymerase II (show 0 Antibodies)-dependent transcription through inhibiting the activity of cyclin T1/Cdk9 (show CDK9 Antibodies) complex.

  7. The sequence domain of human cytomegalovirus pUL97 responsible for the interaction with cyclin T1 was between amino acids 231-280.

  8. the release of P-TEFb from the 7SK snRNP (show LSM2 Antibodies) led to increased synthesis of HEXIM1 (show HEXIM1 Antibodies) but not HEXIM2 (show HEXIM2 Antibodies)

  9. All of the hCD4/R5/cT1 (show CTF1 Antibodies) mice developed disseminated infection of tissues that included the spleen, small intestine, lymph nodes and lungs after intravenous injection with an HIV-1 infectious molecular clone

  10. positive transcription elongation factor b (P-TEFb (show CDK9 Antibodies), made of CDK9 (show CDK9 Antibodies) and CycT1) is released from its inhibitory complex by histone deacetylase (show HDAC1 Antibodies) inhibitors, which also activate HIV transcription

Mouse (Murine) Cyclin T1 (CCNT1) interaction partners

  1. Data show that the minimal 90-amino acid AF9 (show MLLT3 Antibodies) fragment in MLL (show MLL Antibodies)-AF9 (show MLLT3 Antibodies) retains an ability to form higher order complexes with AF4*P-TEFb and with DOT1 (show DOT1L Antibodies).

  2. Data show that the CDK9 (show CDK9 Antibodies) and cyclin T1 subunits of P-TEFb are present in mouse oocytes and preimplantation embryos, and that CDK9 (show CDK9 Antibodies) is essential for embryonic genome activation in the mouse.

  3. Cyclin T1 oncogenic function and suggest a role for this protein in controlling cell cycle probably via Rb/E2F1 (show E2F1 Antibodies) pathway.

  4. CDK9 (show CDK9 Antibodies) has the intrinsic property to shuttle between nucleus and cytoplasm, and enhanced expression of cyclin T1 promotes its nuclear localization.

  5. P-TEFb is a key mediator of Myc (show MYC Antibodies) activated transcription by stimulating elongation

  6. Tat (show TAT Antibodies) and trans-activation-responsive (TAR (show RBM8A Antibodies)) RNA-independent induction of HIV-1 long terminal repeat by this protein requires Sp1 (show SP1 Antibodies).

  7. cyclin T1 binds with granulin (show GRN Antibodies) to inhibit transcription

  8. location of the cyclin T1 gene regulatory elements is male germ cell-specific

  9. These data link the P-TEFb equilibrium to the intracellular transcriptional demand and proliferative/differentiated states of cells.

  10. knockdown of CycT1 from P-TEFb abolishes both of the different chromatin loops regulating CD4 (show CD4 Antibodies) expression

Cyclin T1 (CCNT1) Antigen Profile

Protein Summary

This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9, and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, there are multiple forms of positive transcription elongation factor b, which may include one of several different cyclins along with cyclin-dependent kinase 9. The complex containing the encoded cyclin and cyclin-dependent kinase 9 acts as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and is both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner are also involved in triggering transcript elongation through phosphorylation of the carboxy-terminal domain of the largest RNA polymerase II subunit. Overexpression of this gene is implicated in tumor growth. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with anti-Cyclin T1 (CCNT1) Antibodies

  • Cyclin T (CycT) antibody
  • cyclin T1 (CCNT1) antibody
  • cyclin T1 (ccnt1) antibody
  • cyclin T1 (Ccnt1) antibody
  • cyclin T1 L homeolog (ccnt1.L) antibody
  • 2810478G24Rik antibody
  • AI115585 antibody
  • anon-74EFc antibody
  • CCNT antibody
  • CG6292 antibody
  • Cyclin-T1 antibody
  • CycT1 antibody
  • Dmcyclin T antibody
  • Dmel\\CG6292 antibody
  • dT antibody
  • fi75b02 antibody
  • HIVE1 antibody
  • ORE-14 antibody
  • P-TEFb antibody
  • p124 antibody
  • si:dkey-18f23.10 antibody
  • wu:fi75b02 antibody

Protein level used designations for anti-Cyclin T1 (CCNT1) Antibodies

CG6292-PA , CG6292-PB , CG6292-PC , CG6292-PD , CycT-PA , CycT-PB , CycT-PC , CycT-PD , CyclinT , cyclin T , cyclin T1 , cyclin T2 , dCyclin T , cyclin-T1-like , CDK9-associated C-type protein , cyclin C-related protein , cyclin-T1 , human immunodeficiency virus type 1 (HIV-1) expression (elevated) 1 , cyclin-T , cycT1 , cyclin T1 protein

39961 Drosophila melanogaster
707754 Macaca mulatta
100170179 Xenopus (Silurana) tropicalis
100409876 Callithrix jacchus
100352150 Oryctolagus cuniculus
100583185 Nomascus leucogenys
904 Homo sapiens
12455 Mus musculus
315291 Rattus norvegicus
334465 Danio rerio
734952 Xenopus laevis
486564 Canis lupus familiaris
407194 Bos taurus
100033893 Equus caballus
450146 Pan troglodytes
100860835 Capra hircus
101106415 Ovis aries
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