anti-Cyclin T1 (CCNT1) Antibodies

CCNT1 encodes a member of the highly conserved cyclin C subfamily. Additionally we are shipping Cyclin T1 Kits (13) and Cyclin T1 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CCNT1 904 O60563
CCNT1 12455 Q9QWV9
CCNT1 315291  
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Top anti-Cyclin T1 Antibodies at

Showing 10 out of 84 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB Cyclin T1 was detected in paraffin-embedded sections of human intestinal cancer tissues using rabbit anti- Cyclin T1 Antigen Affinity purified polyclonal antibody (Catalog # ) at 1 µg/mL. The immunohistochemical section was developed using SABC method (Catalog # SA1022). Cyclin T1 was detected in paraffin-embedded sections of mouse intestine tissues using rabbit anti- Cyclin T1 Antigen Affinity purified polyclonal antibody (Catalog # ) at 1 ??g/mL. The immunohistochemical section was developed using SABC method (Catalog # SA1022). 100 μg 4 to 6 Days
Human Rabbit Un-conjugated ELISA, WB 0.1 mg 2 to 3 Days
Human Rabbit Un-conjugated EIA, FACS, IHC (p), WB CCNT1 Antibody (Center) flow cytometric analysis of MCF-7 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. CCNT1 Antibody (Center) western blot analysis in K562 cell line lysates (35µg/lane).This demonstrates the CCNT1 antibody detected the CCNT1 protein (arrow). 0.4 mL 6 to 8 Days
Cow Rabbit Un-conjugated WB WB Suggested Anti-CCNT1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  721_B cell lysate CCNT1 is supported by BioGPS gene expression data to be expressed in 721_B Host:  Rabbit  Target Name:  CCNT1  Sample Type:  MCF7  Antibody Dilution:  1.0ug/ml  CCNT1 is supported by BioGPS gene expression data to be expressed in MCF7 100 μL 2 to 3 Days
Bat Rabbit Un-conjugated WB 100 μL 11 to 14 Days
Human Rabbit Un-conjugated ELISA, IHC, IHC (p), IP, WB Human Skin (formalin-fixed, paraffin-embedded) stained with CCNT1 antibody ABIN218501 at 1:500 followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Anti-CCNT1 / Cyclin T1 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:500. 50 μL 11 to 14 Days
Human Rabbit Un-conjugated ELISA, IHC, WB Western blot analysis of extracts of K562, using CCNT1 antibody. The lane on the left is treated with the antigen-specific peptide. ABIN6277049 at 1/100 staining Human breast cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL 11 to 12 Days
Human Rabbit Un-conjugated EIA, IHC (fro), IHC (p), IP, WB   0.1 mL 4 to 8 Days
Human Rabbit Un-conjugated IHC, WB 100 μL 11 to 13 Days
Human Rabbit Un-conjugated IP, IHC, ELISA, WB Amino acids are numbered on the bottom of each protein. The cyclin box is indicated. Human cyclins T2a and T2b have 642 amino acids in common but different carboxyl termini (black boxes). Background Information:  Cyclin T1, together with the kinase CDK9, is a component of the transcription elongation factor P-TEFb which binds the human immunodeficiency virus type 1 (HIV-1) transactivator Tat. Tat stimulates human HIV-1 viral transcription elongation.  This suggests that cyclin T1/cdk9(PITALRE) is one of the HIV-1 required host cellular cofactors generated during T cell activation. Cyclin T1/cdk9(PITALRE) is shown to interact with Tat to restore Tat activation in HeLa nuclear extracts depleted of P-TEFb.   P-TEFb facilitates transcription by phosphorylating the carboxy-terminal domain (CTD) of RNA polymerase II. The cdk9(PITALRE) activity and cyclin T1 are essential for activation of transcription when tethered to the heterologous Rev response element RNA via the regulator of expression of virion Rev.  Cyclin T1 is an exceptionally large cyclin and is therefore a candidate for interactions with regulatory proteins. 100 μL 5 to 7 Days

Top referenced anti-Cyclin T1 Antibodies

  1. Cow (Bovine) Polyclonal Cyclin T1 Primary Antibody for WB - ABIN2792158 : Sun, Zheng, Zhao, Lee, Goldstein: Increased in vivo activation of microglia and astrocytes in the brains of mice transgenic for an infectious R5 human immunodeficiency virus type 1 provirus and for CD4-specific expression of human cyclin T1 in response to stimulation by lipopolysaccharide in Journal of virology 2008 (PubMed)

  2. Human Polyclonal Cyclin T1 Primary Antibody for EIA, FACS - ABIN951765 : Moiola, De Luca, Gardner, Vazquez, De Siervi: Cyclin T1 overexpression induces malignant transformation and tumor growth. in Cell cycle (Georgetown, Tex.) 2010 (PubMed)
    Show all 5 Pubmed References

More Antibodies against Cyclin T1 Interaction Partners

Fruit Fly (Drosophila melanogaster) Cyclin T1 (CCNT1) interaction partners

  1. We conclude that a subset of non-paused, pre-cellular genes are among the most susceptible to reduced P-TEFb, SEC and Mediator levels in Drosophila embryos.

  2. following P-TEFb inhibition, most polymerases were restricted to within 150 bp of the transcription initiation site of the active Drosophila melanogaster Hsp70 gene, and live-cell imaging demonstrated that these polymerases were stably associated

Human Cyclin T1 (CCNT1) interaction partners

  1. CycT1 is most highly upregulated in maximally activated memory CD4 T cells as expected, but may become less associated with T cell activation during HIV replication.

  2. ASF/SF2 is identified as a splicing regulator of cyclin T1, which contributes to the control of the subsequent transcription events.

  3. The TAR central loop contacts the CycT1 Tat-TAR recognition motif (TRM) and the second Tat Zn(2+)-binding loop. Hydrogen-deuterium exchange (HDX) shows that AFF4 helix 2 is stabilized in the TAR complex despite not touching the RNA, explaining how it enhances TAR binding to the SEC 50-fold.

  4. Quantitative measurement of the molecular interactions among Tat, CycT1 and CDK9 has showed that any third molecule enhances the binding between the other two molecules. These findings suggest that each component of the Tat:P-TEFb complex stabilizes the overall complex, thereby supporting the efficient transcriptional elongation during viral RNA synthesis.

  5. the introduction of HIV-1 Tat and Mg12+ ion resulted in the active site architectural characteristics of phosphorylated CDK9/cyclin T1 complex

  6. AFF4 is positioned to make unexpected direct contacts with HIV Tat, and Tat enhances P-TEFb/CCNT1 affinity for AFF4.

  7. Plk1 negatively regulates the RNA polymerase II-dependent transcription through inhibiting the activity of cyclin T1/Cdk9 complex.

  8. The sequence domain of human cytomegalovirus pUL97 responsible for the interaction with cyclin T1 was between amino acids 231-280.

  9. the release of P-TEFb from the 7SK snRNP led to increased synthesis of HEXIM1 but not HEXIM2

  10. All of the hCD4/R5/cT1 mice developed disseminated infection of tissues that included the spleen, small intestine, lymph nodes and lungs after intravenous injection with an HIV-1 infectious molecular clone

  11. positive transcription elongation factor b (P-TEFb, made of CDK9 and CycT1) is released from its inhibitory complex by histone deacetylase inhibitors, which also activate HIV transcription

  12. CYCT1b is a newly identified cyclin T1 splice variant whose expression leads to direct inhibition of TAT-transactivated transcription of the HIV-1 LTR promoter

  13. Structural determination of a short-lived conformational state between CCNT1 and CDK9 that is adopted during the phosphorylation cycle.

  14. The authors find that resting CD4(+) T cells, whether naive or memory and independent of their HIV infection status, have low levels of Cyclin T1 and T-loop-phosphorylated CDK9, which increase upon activation.

  15. N-terminal residues in cyclin T1 are specifically involved in the binding of cyclin T1 to HEXIM1 but not to Tat.

  16. MiR-27b, miR-29b, miR-223, and miR-150 are regulators of cyclin T1 protein levels and HIV-1 replication in resting CD4+ T cells.

  17. The role of the CycT1 N-terminal region in Tat action, was investigated.

  18. This investigation reveals a novel mechanism of cyclin T1 regulation and establishes NF90 as a regulator of HIV-1 replication during both productive infection and induction from latency.

  19. Cyclin K inhibits HIV-1 gene expression and replication by interfering with cyclin-dependent kinase 9 (CDK9)-cyclin T1 interaction in Nef-dependent manner.

  20. HCMV inter-regulation with CDK9/cyclin T1 is at least partly based on a pUL69-cylin T1 interaction.

Mouse (Murine) Cyclin T1 (CCNT1) interaction partners

  1. CDK9-cyclin T1 and CDK9-cyclin T2/K complexes have opposing roles in CHOP expression and chronic kidney disease -induced vascular calcification.

  2. Data show that the minimal 90-amino acid AF9 fragment in MLL-AF9 retains an ability to form higher order complexes with AF4*P-TEFb and with DOT1.

  3. Data show that the CDK9 and cyclin T1 subunits of P-TEFb are present in mouse oocytes and preimplantation embryos, and that CDK9 is essential for embryonic genome activation in the mouse.

  4. Cyclin T1 oncogenic function and suggest a role for this protein in controlling cell cycle probably via Rb/E2F1 pathway.

  5. CDK9 has the intrinsic property to shuttle between nucleus and cytoplasm, and enhanced expression of cyclin T1 promotes its nuclear localization.

  6. P-TEFb is a key mediator of Myc activated transcription by stimulating elongation

  7. Tat and trans-activation-responsive (TAR) RNA-independent induction of HIV-1 long terminal repeat by this protein requires Sp1.

  8. cyclin T1 binds with granulin to inhibit transcription

  9. location of the cyclin T1 gene regulatory elements is male germ cell-specific

  10. These data link the P-TEFb equilibrium to the intracellular transcriptional demand and proliferative/differentiated states of cells.

  11. knockdown of CycT1 from P-TEFb abolishes both of the different chromatin loops regulating CD4 expression

  12. the reduced level of CLP-1 introduced in the background of elevated levels of cyclin T1 elevates derepression of P-TEFb activity and emphasizes the importance of the role of CLP-1 in the mechanism governing compensatory hypertrophy in cardiomyocytes.

Cyclin T1 (CCNT1) Antigen Profile

Protein Summary

This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9, and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, there are multiple forms of positive transcription elongation factor b, which may include one of several different cyclins along with cyclin-dependent kinase 9. The complex containing the encoded cyclin and cyclin-dependent kinase 9 acts as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and is both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner are also involved in triggering transcript elongation through phosphorylation of the carboxy-terminal domain of the largest RNA polymerase II subunit. Overexpression of this gene is implicated in tumor growth. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with anti-Cyclin T1 (CCNT1) Antibodies

  • Cyclin T (CycT) antibody
  • cyclin T1 (CCNT1) antibody
  • cyclin T1 (ccnt1) antibody
  • cyclin T1 (Ccnt1) antibody
  • cyclin T1 L homeolog (ccnt1.L) antibody
  • 2810478G24Rik antibody
  • AI115585 antibody
  • anon-74EFc antibody
  • CCNT antibody
  • CG6292 antibody
  • Cyclin-T1 antibody
  • CycT1 antibody
  • Dmcyclin T antibody
  • Dmel\\CG6292 antibody
  • dT antibody
  • fi75b02 antibody
  • HIVE1 antibody
  • ORE-14 antibody
  • P-TEFb antibody
  • p124 antibody
  • si:dkey-18f23.10 antibody
  • wu:fi75b02 antibody

Protein level used designations for anti-Cyclin T1 (CCNT1) Antibodies

CG6292-PA , CG6292-PB , CG6292-PC , CG6292-PD , CycT-PA , CycT-PB , CycT-PC , CycT-PD , CyclinT , cyclin T , cyclin T1 , cyclin T2 , dCyclin T , cyclin-T1-like , CDK9-associated C-type protein , cyclin C-related protein , cyclin-T1 , human immunodeficiency virus type 1 (HIV-1) expression (elevated) 1 , cyclin-T , cycT1 , cyclin T1 protein

39961 Drosophila melanogaster
707754 Macaca mulatta
100170179 Xenopus (Silurana) tropicalis
100409876 Callithrix jacchus
100352150 Oryctolagus cuniculus
100583185 Nomascus leucogenys
904 Homo sapiens
12455 Mus musculus
315291 Rattus norvegicus
334465 Danio rerio
734952 Xenopus laevis
486564 Canis lupus familiaris
407194 Bos taurus
100033893 Equus caballus
450146 Pan troglodytes
100860835 Capra hircus
101106415 Ovis aries
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