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The protein encoded by CDK20 contains a kinase domain most closely related to the cyclin-dependent protein kinases. Additionally we are shipping Cyclin-Dependent Kinase 20 Antibodies (105) and Cyclin-Dependent Kinase 20 Proteins (12) and many more products for this protein.
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Results delineate an immunosuppressive mechanism of the hepatoma-intrinsic CCRK signalling and highlight an overexpressed kinase target whose inhibition might empower hepatocellular carcinoma immunotherapy
A CCRK-EZH2 epigenetic circuitry drives hepatocarcinogenesis and associates with tumor recurrence and poor survival of patient.
In glioblastoma cells with deregulated high levels of CCRK, its depletion restores cilia through ICK and an ICK-related kinase MAK, thereby inhibiting glioblastoma cell proliferation.
Data indicate that expression of ERAS, LHX1, and CCRK is increased in aggressive subgroups of medulloblastomas.
Cell cycle-related kinase is a direct androgen receptor-regulated gene that drives beta-catenin/T cell factor-dependent hepatocarcinogenesis
results suggest for the first time that CCRK is involved in colorectal cancer carcinogenesis and G1/S cell cycle transition by regulating Cdk2, cyclin E and Rb.
identification of p42, a novel cyclin-dependent kinase-activating kinase (CAK) activity in human cells; p42 is essential for the phosphorylation of Thr-160 and activation of CDK2 and is indispensable for cell growth
Depletion of PNQALRE by >80% due to RNA interference (RNAi) impairs cell proliferation, but fails to arrest the cell cycle at a discrete point.
Overexpression of CCRK is associated with ovarian carcinoma.
heart expresses a splice variant of CCRK, which promotes cardiac cell growth and survival; differs from the generic isoform in protein-protein interactions, substrate specificity and regulation of cell cycle; and is down-regulated in heart failure
The protein encoded by this gene contains a kinase domain most closely related to the cyclin-dependent protein kinases. The encoded kinase may activate cyclin-dependent kinase 2 and is involved in cell growth. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
, CDK-activating kinase p42
, cell cycle-related kinase
, cell division protein kinase 20
, cyclin-dependent protein kinase H
, cyclin-kinase-activating kinase p42
, cell cycle related kinase
, cell cycle-related kinase cardiac
, CDK-related protein kinase PNQLARE
, cyclin-dependent kinase 20
, LOW QUALITY PROTEIN: cyclin-dependent kinase 20