Cystatin E/M Proteins (CST6)

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Additionally we are shipping CST6 Antibodies (98) and CST6 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CST6 1474 Q15828
CST6 73720  
Rat CST6 CST6 171096  
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Top CST6 Proteins at antibodies-online.com

Showing 10 out of 17 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Human Cells Human His tag 10 μg Log in to see 20 to 21 Days
$250.80
Details
Human Cells Mouse His tag 10 μg Log in to see 20 to 21 Days
$250.80
Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,465.26
Details
Mammalian Cells Mouse His tag   50 μg Log in to see 4 Days
$522.50
Details
Mammalian Cells Human His tag   50 μg Log in to see 4 Days
$522.50
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$608.00
Details
Escherichia coli (E. coli) Human His tag 0.5 mg Log in to see 13 to 16 Days
$492.31
Details
HEK-293 Cells Human His tag Validation with Western Blot 10 μg Log in to see 8 to 11 Days
$504.90
Details
Escherichia coli (E. coli) Human His tag 50 μg Log in to see 15 to 19 Days
$492.31
Details

CST6 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, , ,
Mouse (Murine) , ,

More Proteins for Cystatin E/M (CST6) Interaction Partners

Human Cystatin E/M (CST6) interaction partners

  1. Data suggest that melanoma cells internalize/absorb cystatin C (show CST3 Proteins) from culture media, leading to increased intracellular cystatin C (show CST3 Proteins) levels; cystatin E/M is internalized as well but at modest rate due to down-regulation of cell migration; however, the effect of intracellular cystatin E/M on down-regulation of legumain (show LGMN Proteins) activity is pronounced.

  2. Results provide evidence that cystatin E/M is a tumor suppressor gene which plays an important role in the regulation of NF-kappaB (show NFKB1 Proteins).

  3. Low CST6 expression is associated with breast cancer.

  4. Developed a Methylation-Sensitive High Resolution Melting Analysis (MS-HRMA) assay for the investigation of CST6 promoter methylation in breast cancer patients.CST6 promoter was methylated in 39/80 of FFPEs.

  5. The CST6 promoter is highly methylated in circulating cell-free DNA of breast cancer patients, but not in healthy individuals.

  6. Data show a regulatory role of cystatin E/M in controlling both intra- and extracellular legumain (show LGMN Proteins) activity.

  7. The ectopic expression of CST6 in cancer cells rescued mice from overt osteolytic metastasis and deaths in the animal study, while CST6 knockdown markedly enhanced cancer cell bone metastasis and shortened animal survival.

  8. An association between the quantity of CST6 methylation and the expression statuses of estrogen receptor (show ESR1 Proteins), progesterone receptor (show PGR Proteins), and HER4 (show ERBB4 Proteins) in tumor tissues was found

  9. the level of cystatin E/M regulates legumain (show LGMN Proteins) activity and hence the invasive potential of human melanoma cells

  10. CST6 is not a major gene contributing to type 1 and 2 harlequin ichthyosis

Mouse (Murine) Cystatin E/M (CST6) interaction partners

  1. Using quenched activity-based probes, we identified mouse cathepsin B (CtsB (show CTSB Proteins)), which is expressed in the lower regions of the hair follicle, as an additional target of mouse Cst6

  2. conclude that a tightly regulated balance between cathepsin L (show CTSL1 Proteins) and cystatin M/E is essential for tissue integrity in epidermis, hair follicles, and corneal epithelium

  3. cystatin M/E has a role in skin barrier formation and a potential role as a tumor suppressor gene [review]

CST6 Protein Profile

Protein Summary

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. This gene encodes a cystatin from the type 2 family, which is down-regulated in metastatic breast tumor cells as compared to primary tumor cells. Loss of expression is likely associated with the progression of a primary tumor to a metastatic phenotype.

Gene names and symbols associated with Cystatin E/M Proteins (CST6)

  • cystatin E/M (CST6)
  • cystatin E/M (Cst6)
  • 1110017E11Rik protein
  • CST6 protein
  • ichq protein
  • N28197 protein

Protein level used designations for Cystatin E/M Proteins (CST6)

cystatin E/M , cystatin M , cystatin-M , cystatin 6 , cystatin M/E , cystatin-6 , cystatin-E , cysteine proteinase inhibitor , harlequin ichthyosis , harlequin ichthysosis , cystatin N

GENE ID SPECIES
466668 Pan troglodytes
503685 Bos taurus
714999 Macaca mulatta
1474 Homo sapiens
483719 Canis lupus familiaris
73720 Mus musculus
171096 Rattus norvegicus
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