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CSRP2 is a member of the CSRP family of genes, encoding a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. Additionally we are shipping Cysteine and Glycine-Rich Protein 2 Antibodies (92) and and many more products for this protein.
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CSRP2 promoted cell proliferation, cell-cycle progression, in vitro colony formation and cell migration ability. Abnormal CSRP2 expression was associated with resistance to chemotherapy; sensitivity was restored by down-regulating CSRP2 expression.
the effect of proteasome inhibition on IL-10 (show IL10 Proteins) activation of the IL-10E1 pathway [Il-10E1]
It is a non-Hsp gene, which is essential for HSF1 (show HSF1 Proteins)-mediated maintenance of whole body homeostasis.
CRP2 (show CEBPB Proteins) sequesters p130Cas (show BCAR1 Proteins) at focal adhesions, thereby reducing lamellipodia formation and blunting vascular smooth muscle cell migration.
CRP2 localization dynamics, which affect CRP2 function, are regulated by the formation of actin stress fibers in conjunction with smooth muscle cell differentiation.
Although CRP2 expression during development is independent of CArG box, its expression in adult vascular smooth muscle requires CArG2 within intron 1 and might be mediated by myocardin factors.
evolutionarily conserved Lin-11, Isl-1 (show ISL1 Proteins), Mac-3 (LIM) domain protein (show PDLIM7 Proteins) that have been implicated in cell differentiation.
Presence of vascular smooth muscle cell-specific element(s) within bp -573 to -550 of CSRP2 5'-flanking sequence. Transcriptional regulation of CSRP2 gene is not dependent on dominant-negative serum response factor.
CRP2 acted as a potent transcription coadaptor that remodeled silent cardiac myocyte chromatin and directed serum response factor-dependent smooth muscle gene activity.
CRP2 (show CEBPB Proteins) is a new downstream effector of cGMP/cGMP-dependent protein kinase I (cGKI (show PRKG1 Proteins))-mediated spinal nociceptive processing that plays an inhibitory role in the generation of inflammatory pain.
TGFbeta (show TGFB1 Proteins) activates ATF2 (show ATF2 Proteins) phosphorylation and Csrp2 gene expression via a CRE promoter element.
Lack of Csrp2 is associated with alterations in cardiomyocyte thickness and hypertrophy in mice.
CSRP3 (show CSRP3 Proteins) coding gene from porcine muscle was isolated and characterized and Phylogenetic analyses demonstrated that CSRP3 (show CSRP3 Proteins) diverged first and is distinguished from two other members, CSRP1 (show CSRP1 Proteins) and CSRP2.
CSRP2 is a member of the CSRP family of genes, encoding a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. CRP2 contains two copies of the cysteine-rich amino acid sequence motif (LIM) with putative zinc-binding activity, and may be involved in regulating ordered cell growth. Other genes in the family include CSRP1 and CSRP3.
LIM domain only 5, smooth muscle
, LIM domain only protein 5
, cysteine-rich protein 2
, smooth muscle cell LIM protein
, cysteine and glycine-rich protein 2
, cysteine and glycine-rich protein 1
, double LIM protein 1
, LIM/double zinc-finger protein
, cysteine rich protein 2
, beta-cysteine-rich protein
, Cysteine and glycine-rich protein 2
, muscle lim protein