anti-Cysteinyl Leukotriene Receptor 1 (CYSLTR1) Antibodies

The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Additionally we are shipping CysLTR1 Kits (13) and CysLTR1 Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CYSLTR1 10800 Q9Y271
CYSLTR1 58861 Q99JA4
CYSLTR1 114099 Q924T8
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Top anti-CysLTR1 Antibodies at antibodies-online.com

Showing 10 out of 79 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB 100 μL 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IP, WB Western blot analysis of CYSLTR1 expression in A10 (A), HT29 (B) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated IF, ELISA, WB Western blot analysis of extracts from COS7 cells, using CLTR1 Antibody. The lane on the right is treated with the synthesized peptide. Immunofluorescence analysis of HuvEc cells, using CLTR1 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of CYSLTR1 staining in Jurkat cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antib Immunohistochemical analysis of CYSLTR1 staining in human lymph node formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated wit 200 μL 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of CYSLTR1 Antibody (Center) in ZR-75-1 cell line lysates (35ug/lane). This demonstrates the CYSLTR1 antibody detected the CYSLTR1 protein (arrow). 0.4 mL 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated ELISA, IF, WB Western Blot (WB) analysis of specific cells using CysLTR1 Polyclonal Antibody. 100 μL Available
$363.46
Details
Human Rabbit Un-conjugated ELISA, IF, IHC, WB 100 μL Available
$363.46
Details
Human Rabbit Un-conjugated ELISA, IF, IHC, IHC (p), WB Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated IHC, IHC (p) Anti-CYSLTR1 / CYSLT1 antibody  ABIN1048488 IHC staining of human nasal mucosa, allergic rhinitis, eosinophils. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-CYSLTR1 / CYSLT1 antibody IHC of human Lymph Node, Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated IHC, IHC (p) Anti-CYSLTR1 / CYSLT1 antibody  ABIN1048487 IHC staining of human nasal mucosa, allergic rhinitis, eosinophils. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-CYSLTR1 / CYSLT1 antibody IHC of human Lymph Node, Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg 11 to 14 Days
$484.00
Details

Top referenced anti-CysLTR1 Antibodies

  1. Human Polyclonal CysLTR1 Primary Antibody for FACS, IHC (p) - ABIN4301918 : Woszczek, Pawliczak, Qi, Nagineni, Alsaaty, Logun, Shelhamer: Functional characterization of human cysteinyl leukotriene 1 receptor gene structure. in Journal of immunology (Baltimore, Md. : 1950) 2005 (PubMed)
    Show all 2 Pubmed References

More Antibodies against CysLTR1 Interaction Partners

Human Cysteinyl Leukotriene Receptor 1 (CYSLTR1) interaction partners

  1. Drugs antagonizing the CysLT1 receptor, termed lukasts and typified by montelukast, are established therapeutics for clinical management of asthma.. Here we describe recent data indicating that montelukast may be used for prevention and treatment of AAA, thus representing a promising pharmacological tool for a deadly vascular disease with significant socio-economic impact.

  2. findings strongly implicate that cysLTR1 has the capacity to regulate cellular senescence in chondrocytes. It is suggested that montelukast may be a potential therapeutic agent for chondro-protective therapy.

  3. The expression of CysLTR1 and CysLTR2 is higher in the lymphocytes of hyperplasic tonsils in nonallergic children

  4. SE sensitization may be a risk factor for TH2 inflammation in nonatopic asthma and late-onset asthma and for pulmonary function decline in nonatopic asthma. In women with asthma, a CysLTR1 promoter polymorphism may be associated with SEB sensitization.

  5. In addition, TGF-beta1-induced expression of MMP-1 and MMP-3, generation of fibronectin and type I collagen production, focal adhesion kinase (FAK) and paxillin phosphorylation in HTFs were also ameliorated by montelukast in a dose dependent manner. These results suggested that montelukast might provide therapeutic possibilities for inhibition of scar formation after such surgery.

  6. CysLTRs -1 and -2 seem to be involved in lymphocyte maturation that occurs in tonsils, without influence of allergies.

  7. Data show that cysteinyl leukotriene receptor antagonists (LTRAs) users had a significantly lower cancer incidence rate than LTRA non-users did.

  8. in allergen-sensitized individuals, exposure to allergen can enhance T cell expression of CysLT1. This, in turn, would induce enhanced CD4+ T cell responsiveness to cysLTs, T cell activation, and Th2 polarization.

  9. CysLTR-1 and CysLTR-2 are highly expressed in the adenoid tissues from children with AH, suggesting that leukotrienes are involved in the pathogenesis of AH.

  10. The 5-LOX/LTC4 /CysLT1 signaling pathway regulates EGF-induced cell migration by increasing Tiam1 expression.

  11. Cysteinyl leukotrienes signaling downstream of CysLT1R in mast cells is differentially regulated by two distinct PKCalpha and PKC epsilon.

  12. CysLT(1) receptors in endothelial cells translocate to the nucleus in a ligand-independent manner after ischemic insult in vitro, and it is involved in the ischemic injury.

  13. A significant relationship was found between the expression of CysLT1 receptor and GR-beta in nasal polyps (R = .525, P = .04), whereas there was no significant relationship between the expression of CysLT1 receptor and GR-alpha in nasal polyps.

  14. Genetic variant may play a role in NSAID induced acute urticaria.

  15. A role of nuclear CysLT(1) receptor signaling in vascular smooth muscle cells inducing gene expression patterns associated with atherosclerosis.

  16. Bronchial mucosal CysLT1 receptor-positive inflammatory cells are present in the bronchial mucosa in COPD in greatest number in those experiencing a severe exacerbation.

  17. increased expression in tonsillar tissues of Chinese children with sleep-disordered breathing

  18. Data suggest that CysLT1 induces chemokine-like effects, supports accumulation and survival of chronic lymphocytic leukemia (CLL) cells in the bone marrow and thus represents a potential treatment target.

  19. cysteinyl-leukotriene receptors are differently expressed in fibroblast from peripheral versus central airways in asthmatics and healthy controls.

  20. upon ligand activation, CysLT(1)R is tyrosine-phosphorylated and released from heterodimers with CysLT(2)R and, subsequently, internalizes from the plasma membrane to the nuclear membrane in a clathrin-, arrestin-3-, and Rab-5-dependent manner

Mouse (Murine) Cysteinyl Leukotriene Receptor 1 (CYSLTR1) interaction partners

  1. these findings highlight the essential role of cysLT1R in suppressing pancreatic insulin secretion, and potentially provided a new insight into understanding the mechanical regulation of glucose homeostasis.

  2. Cysteinyl leukotriene receptor 1 (cysLT1R) regulates osteoclast differentiation and bone resorption.

  3. Montelukast also served a protective role in a murine ovariectomy (OVX) and unloadinginduced bone loss model. Altogether, these results confirmed that the CysLTR1 antagonist exerted an inhibitory effect on OC formation in vitro and in vivo. It may be useful for the treatment of bone diseases associated with excessive bone resorption.

  4. The study presents a genetic approach in a colitis-associated colon cancer model further supporting an important role for CysLT1R signaling in colon tumorigenesis, driving immune mediators to promote immune cell infiltration in tumors.

  5. Mechanistically, the effect of montelukast on osteoblastic differentiation acted by activating the extracellular regulated protein kinases (ERK) pathway. The obtained results suggested that montelukast promotes proliferation and differentiation in osteoblasts exposed to overload mechanics.

  6. this study shows that CysLT1R-deficient mice that were exposed to chlorine demonstrated airway hyperresponsiveness to inhaled methacholine significantly greater than in wild-type BALB/c mice

  7. The important role that CysLTR1 plays in colorectal cancer and intestinal polyps development.

  8. Leukotriene D4 and prostaglandin E2 signals synergize and potentiate vascular inflammation in a mast cell-dependent manner through cysteinyl leukotriene receptor 1 and E-prostanoid receptor 3

  9. Involvement of CysLT1R in a model of asthma.

  10. Suggest that myogenic tone is determined by AT1 and CysLT1 receptors acting together as mechanosensors via Gq/11-protein activation.

  11. It plays a critical role in Ab1e42-induced neurotoxicity.

  12. The CysLT(1) and CysLT(2) receptors were primarily localized in neurons, microglia and neutrophils

  13. CysLT1R mediates LTD4-induced activation of microglial cells.

  14. In an animal model of cognition impairment, CysLT1 receptor signaling is identified as proinflammatory and proamyloidogenic.

  15. a single mutation of Thr151Gly in the 2nd inner loop of sysLT1 had a slight inhibitory effect on the desensitization.

  16. present novel data that CysLT1R is expressed on ILC2s and LTD potently induces CysLT1R-dependent ILC2 production of IL-4, IL-5, and IL-13

  17. CysLT1R, CysLT2R and GPR17 might be involved in the MPTP-induced Parkinson disease damage in mice.

  18. 5-Lipoxygenase mediates RANKL-induced osteoclast formation via the cysteinyl leukotriene receptor 1, and it can serve as a novel therapeutic target for bone-resorption diseases.

  19. leukotriene D(4) recepter may be involved in the development of seizures in mice.

  20. Rotenone induced an increased expression of CysLT(1) receptor in BV2 microglial cells.

CysLTR1 (CYSLTR1) Antigen Profile

Protein Summary

The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR2. This encoded receptor is a member of the superfamily of G protein-coupled receptors. Activation of this receptor by LTD4 results in contraction and proliferation of smooth muscle, oedema, eosinophil migration and damage to the mucus layer in the lung.

Gene names and symbols associated with CYSLTR1

  • cysteinyl leukotriene receptor 1 (cysltr1) antibody
  • cysteinyl leukotriene receptor 1 (CYSLTR1) antibody
  • cysteinyl leukotriene receptor 1 (Cysltr1) antibody
  • cysteinyl leukotriene receptor 1 (LOC100338776) antibody
  • BB147369 antibody
  • Cyslt1 antibody
  • cysLT1R antibody
  • CYSLTR antibody
  • CYSLTR1 antibody
  • HMTMF81 antibody
  • zgc:112062 antibody

Protein level used designations for CYSLTR1

cysteinyl leukotriene receptor 1 , G-protein coupled receptor HG55 , LTD4 receptor , cysteinyl leukotriene D4 receptor

GENE ID SPECIES
553675 Danio rerio
608345 Canis lupus familiaris
706663 Macaca mulatta
742228 Pan troglodytes
782045 Bos taurus
100528780 Ictalurus punctatus
100587169 Nomascus leucogenys
397242 Sus scrofa
10800 Homo sapiens
58861 Mus musculus
114099 Rattus norvegicus
100135514 Cavia porcellus
428691 Gallus gallus
100338776 Oryctolagus cuniculus
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