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The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma.
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Human Polyclonal CysLTR1 Primary Antibody for FACS, IHC (p) - ABIN4301918
Woszczek, Pawliczak, Qi, Nagineni, Alsaaty, Logun, Shelhamer: Functional characterization of human cysteinyl leukotriene 1 receptor gene structure. in Journal of immunology (Baltimore, Md. : 1950) 2005
The expression of CysLTR1 and CysLTR2 (show CYSLTR2 Antibodies) is higher in the lymphocytes of hyperplasic tonsils in nonallergic children
SE sensitization may be a risk factor for TH2 inflammation in nonatopic asthma and late-onset asthma and for pulmonary function decline in nonatopic asthma. In women with asthma, a CysLTR1 promoter polymorphism may be associated with SEB sensitization.
In addition, TGF-beta1-induced expression of MMP-1 and MMP-3, generation of fibronectin and type I collagen production, focal adhesion kinase (FAK) and paxillin phosphorylation in HTFs were also ameliorated by montelukast in a dose dependent manner. These results suggested that montelukast might provide therapeutic possibilities for inhibition of scar formation after such surgery.
in allergen-sensitized individuals, exposure to allergen can enhance T cell expression of CysLT1. This, in turn, would induce enhanced CD4 (show CD4 Antibodies)+ T cell responsiveness to cysLTs, T cell activation, and Th2 polarization.
CysLTR-1 and CysLTR-2 (show CYSLTR2 Antibodies) are highly expressed in the adenoid tissues from children with AH, suggesting that leukotrienes are involved in the pathogenesis of AH.
The 5-LOX (show ALOX5 Antibodies)/LTC4 /CysLT1 signaling pathway regulates EGF (show EGF Antibodies)-induced cell migration by increasing Tiam1 (show TIAM1 Antibodies) expression.
Cysteinyl leukotrienes signaling downstream of CysLT1R in mast cells is differentially regulated by two distinct PKCalpha (show PKCa Antibodies) and PKC epsilon (show PRKCE Antibodies).
CysLT(1) receptors in endothelial cells translocate to the nucleus in a ligand-independent manner after ischemic insult in vitro, and it is involved in the ischemic injury.
A significant relationship was found between the expression of CysLT1 receptor and GR-beta in nasal polyps (R = .525, P = .04), whereas there was no significant relationship between the expression of CysLT1 receptor and GR-alpha in nasal polyps.
A role of nuclear CysLT(1) receptor signaling in vascular smooth muscle cells inducing gene expression patterns associated with atherosclerosis.
The study presents a genetic approach in a colitis-associated colon cancer model further supporting an important role for CysLT1R signaling in colon tumorigenesis, driving immune mediators to promote immune cell infiltration in tumors.
Mechanistically, the effect of montelukast on osteoblastic differentiation acted by activating the extracellular regulated protein kinases (ERK (show EPHB2 Antibodies)) pathway. The obtained results suggested that montelukast promotes proliferation and differentiation in osteoblasts exposed to overload mechanics.
this study shows that CysLT1R-deficient mice that were exposed to chlorine demonstrated airway hyperresponsiveness to inhaled methacholine significantly greater than in wild-type BALB/c mice
The important role that CysLTR1 plays in colorectal cancer and intestinal polyps development.
Leukotriene D4 and prostaglandin E2 signals synergize and potentiate vascular inflammation in a mast cell-dependent manner through cysteinyl leukotriene receptor 1 and E-prostanoid receptor 3
Involvement of CysLT1R in a model of asthma.
Suggest that myogenic tone is determined by AT1 (show SLC33A1 Antibodies) and CysLT1 receptors acting together as mechanosensors via Gq/11-protein activation.
The CysLT(1) and CysLT(2 (show CYSLTR2 Antibodies)) receptors were primarily localized in neurons, microglia and neutrophils
CysLT1R mediates LTD4-induced activation of microglial cells.
In an animal model of cognition impairment, CysLT1 receptor signaling is identified as proinflammatory and proamyloidogenic.
The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR2. This encoded receptor is a member of the superfamily of G protein-coupled receptors. Activation of this receptor by LTD4 results in contraction and proliferation of smooth muscle, oedema, eosinophil migration and damage to the mucus layer in the lung.
cysteinyl leukotriene receptor 1
, G-protein coupled receptor HG55
, LTD4 receptor
, cysteinyl leukotriene D4 receptor