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putative cysteinyl leukotriene receptor [RGD, Feb 2006]..
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our study identifies CYSLTR2 L129Q alterations as a previously unrecognized activating mutation in blue nevi, occuring in a mutually exclusive fashion with known GNAQ (show GNAQ Antibodies) and GNA11 (show GNA11 Antibodies) mutations.
The expression of CysLTR1 (show CYSLTR1 Antibodies) and CysLTR2 is higher in the lymphocytes of hyperplasic tonsils in nonallergic children
findings implicate CYSLTR2 as a uveal melanoma oncogene (show RAB1A Antibodies) and highlight the critical role of Galphaq (show GNAQ Antibodies) signaling in uveal melanoma pathogenesis
CysLT2 receptors were expressed in lung specimens isolated from asthma subjects. Activation of CysLT2 receptors may contribute to antigen-induced bronchoconstriction in certain asthma population.
CysLTR-1 (show CYSLTR1 Antibodies) and CysLTR-2 are highly expressed in the adenoid tissues from children with AH, suggesting that leukotrienes are involved in the pathogenesis of AH.
Suggest that endothelial and nonendothelial CysLT2R niches have separate roles in mediating inflammatory responses in ischemic/perfusion injury.
ATRA treatment induces CysLT(2)R mRNA and protein expression in colon cancer cell lines
CysLT2 receptor plays a primary role in the vascular responses in the upper respiratory tract.
There is a protective role against tumor progression for CysLT(2)R and that it highlights new possibilities to regulate the CysLT(2)R.
The synthesis of cys (show DNAJC5 Antibodies)-LTs from LTA (show LTA Antibodies)(4) by endothelial cells is directly associated with the activation of the CysLT(2) receptor in a typical autocrine fashion.
The CysLT(1 (show CYSLTR1 Antibodies)) and CysLT(2) receptors were primarily localized in neurons, microglia and neutrophils
LTC4 activates mouse platelets exclusively through CysLT2R. LTC4/CysLT2R signaling required an autocrine ADP-mediated response through P2Y12 (show P2RY12 Antibodies) receptors.
CysLT1R (show CYSLTR1 Antibodies), CysLT2R and GPR17 (show GPR17 Antibodies) might be involved in the MPTP (show PTPN2 Antibodies)-induced Parkinson disease damage in mice.
CysLT2R negatively regulates the development of cys (show DNAJC5 Antibodies)-LT-dependent T helper cell (Th)2 pulmonary inflammation by inhibiting both CysLT1R (show CYSLTR1 Antibodies) signaling and house dust mite-induced LTC4S (show LTC4S Antibodies)-dependent cell surface expression of CysLT1R (show CYSLTR1 Antibodies) on dendritic cells.
These findings establish a role for eosinophil-derived cysteinyl leukotriene and the CysLT(2)R in the hyperkeratosis and fibrosis of allergic skin inflammation.
Results implicate the CysLT(2)R in the progression of ischemic retinopathy.
These results suggest that a lack of neuronal expression of CysLTR (show CYSLTR1 Antibodies) in the murine colonic myenteric plexus attenuates colitis disease progression.
findings show that CysLT1 receptor (show CYSLTR1 Antibodies) attenuates while CysLT2 receptor facilitates oxygen glucose deprivation -induced PC12 cell death
CysLT2 receptors interact with CysLT1 (show CYSLTR1 Antibodies) receptors and down-modulate cysteinyl leukotriene dependent mitogenic responses of mast cells.
In luteal-phase endometrium, expression of 5-LO (5-lipoxygenase (show ALOX5 Antibodies)) and LTB4R (leukotriene B4 receptor) is highest on Days 2-4; expression of LTCS (leukotriene-C4 synthase (show LTC4S Antibodies)) and CysLTR2 (cysteinyl leukotriene receptor 2) is highest on Days 16-18. In luteal-phase endometrium, LTB4 (show PTGR1 Antibodies) level is highest on Days 2-4; LTC4 level is highest on Days 16-18. Studies were conducted in Poland on Holstein Polish Black and White dairy cows.
putative cysteinyl leukotriene receptor
cysteinyl leukotriene receptor 2
, G protein-coupled receptor
, G-protein coupled receptor GPCR21
, G-protein coupled receptor HG57
, cysteinyl leukotriene CysLT2 receptor