CasLTR2 antibody

Catalog No. ABIN317732

The Rabbit Polyclonal anti-CasLTR2 antibody is suitable to detect CasLTR2 in samples from Human. It has been validated for WB, IF and EIA.

Quick Overview for CasLTR2 antibody (ABIN317732)

Target: CasLTR2 (CYSLTR2) (Cysteinyl Leukotriene Receptor 2 (CYSLTR2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CasLTR2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Product Details anti-CasLTR2 Antibody

Specificity: This antibody detects endogenous levels of CYSLTR2 protein(region surrrounding His324).

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity-chromatography

Application Details

Application Notes: ELISA: 1: 40000approx. 1: 60000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2, 0.05 % Sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for CasLTR2

Target: CasLTR2 (CYSLTR2) (Cysteinyl Leukotriene Receptor 2 (CYSLTR2))

Alternative Name: CYSLTR2

Background: Cysteinyl leukotriene (CysLTs) induce intracellular calcium mobilization through the binding of two distinct seven-transmembrane, G protein-coupled receptors, designated CysLT1 Receptor and CysLT2 Receptor, to induce potent bronchoconstriction. Airway smooth muscle and macrophages express both receptor types, and additionally monocytes and eosinophils express CysLT1 Receptor, while cardiac Purkinje cells, adrenal medulla, peripheral blood leukocytes and brain also utilize CysLT2 Receptor. The effects of the CysLT Receptors can be blocked by antagonists, indicating a therapeutic mechanism for the treatment of asthma and allergies.Synonyms: CYSLT2, CysLTR2, Cysteinyl leukotriene receptor 2, G-protein coupled receptor GPCR21, G-protein coupled receptor HG57, HG57, HPN321, hGPCR21

Molecular Weight: approx. 40 kDa

Gene ID: 57105

NCBI Accession: NP_065110

UniProt: Q9NS75