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CYP2C8 encodes a member of the cytochrome P450 superfamily of enzymes. Additionally we are shipping CYP2C8 Antibodies (50) and many more products for this protein.
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We found that SNPs rs7909236 and rs1934953 of the CYP2C8 gene were significantly associated with increased risk of essential hypertension.
Clopidogrel increases the exposure to pioglitazone by inhibiting its CYP2C8-mediated biotransformation.
Using an integrated pathway-based approach, we identified polymorphisms in ABCC6 (show ABCC6 Proteins), ABCB1 (show ABCB1 Proteins) and CYP2C8 associated with overall survival. These associations were replicated in a large independent cohort, highlighting the importance of pharmacokinetic genes as prognostic markers in Ewing sarcoma
review summarizes glucuronides as CYP2C8 ligands and the active-site structural features of CYP2C8 that allow potential binding to glucuronides
Preliminary results demonstrate SNPs in CYP2C8 represent potential genetic markers of coronary heart disease susceptibility.
Inhibition of CYP2C8 activity adds to the protective effects of omega-3 LCPUFA on pathological retinal neovascularization and choroidal neovascularization.
CYP2C8*3 carriers had an increased risk of peripheral neuropathy
CYP2C8 Variants are associated with Ischemic Stroke.
This review focuses on recent findings of in vitro studies on drug metabolizing activity of 3 highly polymorphic CYP2C (show CYP2C19 Proteins) members: CYP2C8, CYP2C9 (show CYP2C9 Proteins), and CYP2C19 (show CYP2C19 Proteins).
CYP2C8*3 is a gain-of-function polymorphism for imatinib N-demethylation, which appears to be mainly mediated by CYP2C8 and not CYP3A4 (show CYP3A4 Proteins) in vitro in human liver microsomes
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene.
cytochrome P450 2C8
, cytochrome P450 CYP2C74
, Cytochrome P450 2C8
, cytochrome P450, family 2, subfamily C, polypeptide 8
, P450 form 1
, cytochrome P450 IIC2
, cytochrome P450 MP-12
, cytochrome P450 MP-20
, cytochrome P450 form 1
, cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8
, flavoprotein-linked monooxygenase
, microsomal monooxygenase
, s-mephenytoin 4-hydroxylase
, xenobiotic monooxygenase