anti-Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 (CYP2E1) Antibodies

CYP2E1 encodes a member of the cytochrome P450 superfamily of enzymes. Additionally we are shipping Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 Kits (27) and Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 Proteins (26) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CYP2E1 1571 P05181
CYP2E1 13106 Q05421
CYP2E1 25086 P05182
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Top anti-Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 Antibodies at antibodies-online.com

Showing 10 out of 199 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB Host:  Rabbit  Target Name:  CYP2E1  Sample Tissue:  Human Fetal Lung  Antibody Dilution:  1.0ug/ml 100 μL 2 to 3 Days
$319.00
Details
Human Rabbit Un-conjugated IHC (p), WB Anti- CYP2E1 antibody, IHC(P) IHC(P): Rat Liver Tissue 100 μg 4 to 6 Days
$280.00
Details
Mouse Rabbit Un-conjugated IHC (p), WB Anti-Cytochrome P450 2E1 antibody, Western blotting Lane 1: Rat Liver Tissue Lysate Lane 2: Mouse Liver Tissue Lysate Anti-Cytochrome P450 2E1 antibody, IHC(P) IHC(P): Rat Liver Tissue 100 μg 4 to 6 Days
$280.00
Details
Dog Rabbit Un-conjugated IC, IF, WB Immunofluorescent analysis of Cytochrome P450 2E1 staining in NIH3T3 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Western blot analysis of Cytochrome P450 2E1 expression in HEK293T (A), NIH3T3 (B), H9C2 (C), Human Liver (D) whole cell lysates. 200 μL 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated IF, IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Cytochrome P450 2E1 Antibody. The picture on the right is treated with the synthesized peptide. Immunofluorescence analysis of HepG2 cells, using Cytochrome P450 2E1 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
$302.50
Details
Human Goat Un-conjugated ELISA, IHC, WB   100 μg 6 to 7 Days
$429.84
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, IHC, WB Western blot analysis of Mouse liver tissue lysates, using CYP2E1 Antibody. The lane on the left is treated with the antigen-specific peptide. Western blot analysis of CYP2E1 expression in Mouse Liver lysate 100 μL 11 to 12 Days
$390.77
Details
Rat Rabbit Un-conjugated ICC, IHC, WB Western Blot; Sample: Rat Liver lysate; Primary Ab: 3µg/ml Rabbit Anti-Rat CYP2E1 Antibody Second Ab: 0.2µg/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: SAA544Rb19) 100 μg 15 to 18 Days
$342.00
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg 2 to 3 Days
$515.63
Details
Human Goat Un-conjugated ELISA, IHC, IHC (p), WB 50 μg 11 to 14 Days
$484.00
Details

Top referenced anti-Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 Antibodies

  1. Human Polyclonal CYP2E1 Primary Antibody for IHC (p), WB - ABIN3043821 : Fan, Jiang, Wang, Tan, Zeng, Wang, Chen, Qu, Gonzalez, Huang, Bi: Wuzhi tablet (Schisandra Sphenanthera extract) protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of NRF2-ARE and p53/p21 pathways. in Drug metabolism and disposition: the biological fate of chemicals 2014 (PubMed)
    Show all 3 Pubmed References

  2. Mouse (Murine) Polyclonal CYP2E1 Primary Antibody for IHC (p), WB - ABIN3044118 : Jiang, Fan, Wang, Chen, Zeng, Tan, Gonzalez, Huang, Bi: Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration. in Toxicological sciences : an official journal of the Society of Toxicology 2014 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal CYP2E1 Primary Antibody for IHC, IHC (p) - ABIN4302106 : Hou, Bukong, Kodys, Szabo: Alcohol facilitates HCV RNA replication via up-regulation of miR-122 expression and inhibition of cyclin G1 in human hepatoma cells. in Alcoholism, clinical and experimental research 2013 (PubMed)
    Show all 2 Pubmed References

  4. Mouse (Murine) Polyclonal CYP2E1 Primary Antibody for IHC, WB - ABIN3023079 : Ma, Zhu, Tan, Mao, Tang, Shen, Zhang, Kuang, Fei, Yang, Wang: Gpr110 deficiency decelerates carcinogen-induced hepatocarcinogenesis via activation of the IL-6/STAT3 pathway. in American journal of cancer research 2017 (PubMed)

  5. Human Polyclonal CYP2E1 Primary Antibody for ELISA, IHC - ABIN4302103 : Niu, Yuan, Leng, Pang, Gu, Chen: CYP2E1 Rsa I/Pst I polymorphism and esophageal cancer risk: a meta-analysis based on 1,088 cases and 2,238 controls. in Medical oncology (Northwood, London, England) 2011 (PubMed)

  6. Human Polyclonal CYP2E1 Primary Antibody for IHC, IHC (p) - ABIN4302104 : Fagerberg, Hallström, Oksvold, Kampf, Djureinovic, Odeberg, Habuka, Tahmasebpoor, Danielsson, Edlund, Asplund, Sjöstedt, Lundberg, Szigyarto, Skogs, Takanen, Berling, Tegel, Mulder, Nilsson, Schwenk et al.: Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics. ... in Molecular & cellular proteomics : MCP 2014 (PubMed)

  7. Human Polyclonal CYP2E1 Primary Antibody for WB - ABIN514837 : De Bock, Colin, Boussery, Van Bocxlaer: Quantification of cytochrome 2E1 in human liver microsomes using a validated indirect ELISA. in Journal of pharmaceutical and biomedical analysis 2013 (PubMed)

  8. Dog (Canine) Polyclonal CYP2E1 Primary Antibody for WB - ABIN549202 : Bukulmez, Hardy, Carr, Word, Mendelson: Inflammatory status influences aromatase and steroid receptor expression in endometriosis. in Endocrinology 2008 (PubMed)

  9. Human Polyclonal CYP2E1 Primary Antibody for IF (p), IHC (p) - ABIN707141 : Iwao, Ojima, Kobayashi, Kishi, Nara, Esaki, Shimada, Hiraoka, Tanabe, Kanai: Liver atrophy after percutaneous transhepatic portal embolization occurs in two histological phases: Hepatocellular atrophy followed by apoptosis. in World journal of hepatology 2017 (PubMed)

More Antibodies against Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 Interaction Partners

Rabbit Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 (CYP2E1) interaction partners

  1. The localization of CYP1A2, CYP2B4 and CYP2E1 within the ER was determined by partial membrane solubilization with Brij 98

  2. this study indicates that the gender difference in cytochrome P4503A activity may be one of the important factors for the development of steroid-induced osteonecrosis, possibly due to the effects of oestradiol.

Guinea Pig Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 (CYP2E1) interaction partners

  1. Cytochrome P450 2E1 takes part in the pathogenesis of experimental metabolic syndrome in guinea pigs.

Human Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 (CYP2E1) interaction partners

  1. Data suggest an important role of CYP2E1 in the generation of epsilondA, in the fibrotic progression of alcoholic liver disease, and thus in alcohol-mediated hepatocarcinogenesis.

  2. This first study of polymorphisms in Colombian patients diagnosed with cirrhosis and/or HCC showed genotypes ADH1B*1/1, ADH1C*1/1 and CYP2E1*C/C as the most frequent

  3. Data show that hepatofibrotic patients with higher cytochrome P-450 (CYP2E1) activity more readily develop hepatocellular carcinoma (HCC) and that higher CYP2E1 activity is a risk factor for the development of hepatocarcinogenesis from hepatofibrosis.

  4. A polymorphism of CYP2E1 may be directly associated with the development of Isoniazid hepatotoxicity.

  5. We evaluated genetic variability of single nucleotide polymorphisms (SNPs) situated in the CYP2E1 gene promoter in alcoholics in central Brazil. Our results showed that the allelic frequencies were markedly different among ethnicities and have contributed to the knowledge regarding the distribution among ethnic groups, being associated to alcohol consumption worldwide.

  6. no genetic association between CYP2E1 and alcohol dependence in Han Taiwanese either by single allele tests or haplotype-based analyses

  7. Study provides evidence for an association between CYP2E1 gene polymorphisms and bladder cancer progression, and suggests that CYP2E1 gene polymorphisms might be a protective factor against bladder cancer in Asian people

  8. The results showed that no difference in chromosome damage was found among the three genotypes of CYP2E1.

  9. Report CYP2E1 inhibitory capacity of diallyl sulfide analogs and roles in reducing ethanol- and acetaminophen-induced toxicity in hepatocytes.

  10. CYP2E1 role in actiavation of the polychlorinated biphenyls mutagens

  11. Case-control study found a significant difference was observed between large artery atherosclerotic ischemic stroke patients and controls with respect to the CYP2E1*5B genotype and allele distribution. NQO1*2 polymorphism genotype distribution was significantly different between patients and controls and heterozygote *1*2 genotype was found to be a protective factor against large artery atherosclerotic ischemic stroke.

  12. The observations of the present study give rise to useful information on CYP2E1 polymorphisms in Chinese Uygur individuals.

  13. results provide new information regarding CYP2E1 genetic polymorphisms in Chinese Tibetan population. These findings in this study would be value for further study in assessing the susceptibility of different populations to diseases related to CYP2E1 polymorphisms and determining whether it is necessary to design different therapeutics and toxicological protocols to reduce the risk of population, including pharmacogenetic

  14. Clomethiazole is a direct inhibitor of human CYP2E1 when coincubated with the probe substrate chlorzoxazone.

  15. Methodology to assay CYP2E1 mixed function oxidase catalytic activity and its induction.

  16. Polymorphisms in the promoter region of the CYP2E1 gene were associated with DNA damage in alcoholics.

  17. We identified an exposure-associated differentially methylated region (DMR) spanning nine sequential CpG sites in the promoter-regulatory region of the cytochrome P450 2E1 gene (CYP2E1) on chromosome 10 (corrected P=2.98 x 10(-5)). Elevated DNA methylation across this region was also associated with deprivation-related clinical markers of impaired social cognition.

  18. A significant increase in the risk of non-small cell lung cancer was observed for the following combinations: TP53 codon72 variant with GSTM1 null (OR 2.22, 95 % CI 1.23-4.04; p=0.009), GSTT1 null (OR 2.98, 95 % CI 1.49-5.94; p=0.002), and GSTP1 (Ala114Val) variant genotypes (OR 3.38, 95 % CI 1.54-7.41; p=0.002).

  19. Studied the possible relationship between cytochrome P450, family 2, subfamily E and polypeptide 1 (CYP2E1) polymorphisms with Kawasaki disease (KD). Found the KD patients with a CYP2E1 CC genotype of rs915906 demonstrated a greater proportion of coronary artery lesions (CALs) formation.

  20. The results suggest that changes in coumarin pharmacokinetics and CYP2E1 subcellular distribution contribute to resistance to coumarin-induced hepatic necrosis, while cytotoxicity of metabolic conjugates shown in vitro may contribute to bile duct damage upon repeated coumarin administration.

Mouse (Murine) Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 (CYP2E1) interaction partners

  1. Cyp2e1 mRNA expression was increased by MRSA in the kidney of mice.

  2. The ablation of Rdh13 gene decreased the expression levels of thyroid hormone-inducible nuclear protein 14 (Spot14) and cytochrome P450 (Cyp2e1) in the liver, especially after CCl(4) treatment for 48 h.

  3. results demonstrate that 2,3,4',5-tetrahydroxystilbene-2-O-beta-D-glucoside enhances hepatic expression of CYP3A4, CYP2E1 and CYP1A2, and thus exacerbates the hepatotoxicity induced by acetaminophen in mice.

  4. These findings support the notion that a regulatory cascade comprising PP2A-B56alpha, beta-catenin, and Cyp2e1 is involved in benzene-induced hematotoxicity, providing critical insight into the role of PP2A in responses to the environmental chemicals.

  5. Ethanol-mediated up-regulation of CYP2E1 via SUMOylation enhancing its protein stability and activity and may have important implications in alcoholic liver disease.

  6. these results demonstrate that CYP2E1 is important in fast food-mediated liver fibrosis by promoting nitroxidative and endoplasmic reticulum stress, endotoxemia, inflammation, insulin resistance, and low energy expenditure

  7. The significant increase of Cyp2e1 transcript level and protein expression was found in the liver and hippocampi during spontaneous recurrent seizures in mice.

  8. CYP2E1-induced oxidative stress may be responsible for ethanol-induced suppression of Akt phosphorylation and pharmacological modulation of Akt in liver may be an effective strategy for the treatment of ethanol-induced fatty liver.

  9. BI-1 protects against obesity-induced hepatic insulin resistance by regulating CYP2E1 activity and reactive oxygen species production.

  10. Baicalin inhibited ethanol-induced expression of reactive oxygen species (ROS) generating enzymes NOX2, p67phox, xanthine oxidase, and iNOS in addition to CYP2E1 activities.

  11. Methodology to assay CYP2E1 mixed function oxidase catalytic activity and its induction/

  12. we show that TRPV4 is activated both by damage associated molecular pattern HMGB1 and collagen in diseased Kupffer cells that in turn activate the endothelial NOS (NOS3) to release nitric oxide (NO). The diffusible NO acts in a paracrine fashion in neighboring hepatocytes to deactivate the redox toxicity induced by CYP2E1

  13. Data, including data from studies in knockout mice, suggest that the oxidative metabolism of 1,2-dichloropropane, a carcinogenic solvent/insecticide, is exclusively catalyzed by Cyp2e1; this biotransformation step is indispensable for manifestation of hepatotoxic effect of the solvent.

  14. Taken together, these results suggested that 1,2-dichloroethane (1,2-DCE) could enhance CYP2E1 protein expression and enzymatic activity, which could cause oxidative damage in liver, serving as an important mechanism underlying 1,2-DCE-induced liver damage

  15. CYP2E1 is important in causing aging-dependent hepatic steatosis, apoptosis and fibrosis possibly through increasing nitroxidative stress.

  16. Our results support a significant role for CYP2E1 as a novel 4-Aminobiphenyl N-oxidizing enzyme in adult mice

  17. Schisandrol B protects against APAP-induced liver injury, potentially through inhibition of CYP2E1/3A11-mediated APAP bioactivation and regulation of the p53, p21, CCND1, PCNA, and BCL-2 to promote liver regeneration.

  18. Studied hepatic stellate cell cytoglobin involvement in acetaminophen induced hepatotoxicity through the regulation of CYP2E1.

  19. Data suggest that expression of Cyp2e1 in adipose tissue can be regulated by dietary factors; here, expression of Cyp2e1 in white adipose tissue is down-regulated in obesity caused by high-fat diet.

  20. The Cyp2e1-null mice displayed a susceptibility to lung toxicity of styrene similar to that of the wild-type animals; however, Cyp2f2-null mice were resistant to styrene-induced pulmonary toxicity.

Pig (Porcine) Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 (CYP2E1) interaction partners

  1. this study summarises the current knowledge about the regulation of porcine CYP2A19 and CYP2E1 by environmental, biological and dietary factors. [Review]

  2. A highly significant association was found between variation in skatole levels and SNPs within the CYP2E1 gene on chromosome 14.

  3. The relationship between a single nucleotide polymorphism of CYP2E1 and boar taint in pork from Belgian swine is reported.

  4. the G --> A substitute might be at least partially responsible for a high level of skatole in pigs

Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 (CYP2E1) Antigen Profile

Protein Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.

Gene names and symbols associated with CYP2E1

  • cytochrome P450, family 2, subfamily E, polypeptide 1 (CYP2E1) antibody
  • cytochrome P450 2E1 (CYP2E1) antibody
  • cytochrome P450 2E1 (PTRG_07411) antibody
  • cytochrome P450 2E1 (LOC100342572) antibody
  • cytochrome P450 2E1 (LOC100727914) antibody
  • cytochrome P450 2E1-like (LOC101843716) antibody
  • cytochrome P450 family 2 subfamily E member 1 (CYP2E1) antibody
  • cytochrome P450, family 2, subfamily e, polypeptide 1 (Cyp2e1) antibody
  • CPE1 antibody
  • Cyp2e antibody
  • CYP2E1 antibody
  • CYPIIE1 antibody
  • P450-J antibody
  • P450C2E antibody

Protein level used designations for CYP2E1

cytochrome P450 2E1 , 4-nitrophenol 2-hydroxylase , Cytochrome P450 2E1 , Cytochrome P450 LM3A , Cytochrome P450 isozyme 3A , Cytochrome P450-ALC , Cytochrome P450-J , cytochrome P-450j , CYPIIE1 , cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1 , cytochrome P450-J , flavoprotein-linked monooxygenase , microsomal monooxygenase , xenobiotic monooxygenase , cytochrome P450, 2e1, ethanol inducible , cytochrome P450-ALC , P450-J , P450RLM6 , cytochrome P450 subfamily 2e1 (ethanol-inducible) , cytochrome P450, subfamily 2E, polypeptide 1 , cytochrome P450RLM6 , cytochrome P-450-J , cytochrome P450 CYP2E1

GENE ID SPECIES
100066422 Equus caballus
554344 Felis catus
6345684 Pyrenophora tritici-repentis Pt-1C-BFP
100342572 Oryctolagus cuniculus
100727914 Cavia porcellus
101843716 Mesocricetus auratus
1571 Homo sapiens
415128 Canis lupus familiaris
13106 Mus musculus
25086 Rattus norvegicus
403216 Sus scrofa
282213 Bos taurus
100568285 Ovis aries
678688 Macaca mulatta
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