CYP2E1 antibody (AA 402-429)

Catalog No. ABIN3030687

Product Details anti-CYP2E1 Antibody

Target: CYP2E1 (Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 (CYP2E1))

Binding Specificity: AA 402-429

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CYP2E1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Purification: Purified

Immunogen: A portion of amino acids 402-429 from the human protein was used as the immunogen for this CYP2E1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the CYP2E1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100,Flow Cytometry: 1:10-1:50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the CYP2E1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for CYP2E1

Target: CYP2E1 (Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 (CYP2E1))

Alternative Name: CYP2E1 (CYP2E1 Products)

Synonyms: CYP2E1 antibody, CYP2E antibody, CYPIIE1 antibody, CPE1 antibody, P450-J antibody, P450C2E antibody, Cyp2e antibody, cytochrome P450, family 2, subfamily E, polypeptide 1 antibody, cytochrome P450 2E1 antibody, cytochrome P450 2E1-like antibody, cytochrome P450 family 2 subfamily E member 1 antibody, cytochrome P450, family 2, subfamily e, polypeptide 1 antibody, CYP2E1 antibody, PTRG_07411 antibody, LOC100342572 antibody, LOC100727914 antibody, LOC101843716 antibody, Cyp2e1 antibody

Background: CYP2E1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.

UniProt: P05181