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Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Additionally we are shipping CYP8B1 Proteins (4) and many more products for this protein.
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RORalpha is a key regulator of diurnal rhythm and fasting induction of CYP8B1, which regulates bile acid composition and serum and liver cholesterol levels.
The single nucleotide polymorphism rs3732860 in the 3'-untranslated region of the CYP8B1 gene is associated with risk of Gallstone Disease in Chinese Han.
SNP rs3732860 of CYP8B1 gene is associated with gallstone disease in this Chinese population.
Cholesterol loading reduces SREBP-1 mRNA expression in addition to reducing functional SREBP-1 protein, and results in decreasing CYP8B1 gene transcription.
Studies indicate a homogenous pattern for CYP8B1 expression in human liver, which was even rather than zonal.
T(3) dose-dependently decreased total bile acid formation in parallel with decreased expression of CYP7A1 and CYP8B1
Isoflavone-related induction of 12-alpha-hydroxylase (CYP8B1) was studied in vitro and murine in vivo models.
Cyp8b1(-/-) mice were resistant to Western diet-induced body weight gain, hepatic steatosis, and insulin resistance.
Absence of Cyp8b1 results in improved glucose tolerance, insulin sensitivity, and beta-cell function, mediated by absence of cholic acid in Cyp8b1(-/-) mice.
Cholesterol lowering properties of oats involve increased production of bile acids via the classic pathway with up-regulation of CYP7A1 and CYP8B1.
Feedback regulation of the rate-limiting biosynthetic enzyme CYP7A1 is lost in Cyp8b1(-/-) mice, causing expansion of the bile acid pool and alterations in cholesterol metabolism.
In the intercross between C57BL/6J and CASA/Rk mice, Cyp8b1 is not responsible for biliary bile acid composition.
The expression pattern of Cyp8b1 was studied in hepatocytes.
Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha- hydroxylated C27 steroids.
, cytochrome P450 8b1 sterol 12 alpha-hydrolase
, cytochrome P450, 8b1, sterol 12 alpha-hydrolase
, cytochrome P450, family 8, subfamily B, polypeptide 1
, cytochrome P450, family 8, subfamily B
, 7 alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase
, 7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase
, cytochrome P450 8B1
, cytochrome P450, subfamily VIIIB (sterol 12-alpha-hydroxylase), polypeptide 1
, sterol 12-alpha-hydroxylase
, sterol 12-alpha-hydrolase
, sterol 12-alpha hydroxylase