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CRLF1 encodes a member of the cytokine type I receptor family. Additionally we are shipping Cytokine Receptor-Like Factor 1 Antibodies (53) and Cytokine Receptor-Like Factor 1 Kits (28) and many more products for this protein.
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we show in this series of 12 patients from four families, all previously unpublished, that the homogeneity of the recently described c.983dupG (p.Ser328Argfs *2) mutation in CRLF1 was associated with a highly variable degree of severity, and that the phenotype significantly overlaps with the recently described COG6 (show COG6 Proteins)-related anhidrosis syndrome (MIM (show MTSS1 Proteins)#615328
CLF-1, based on its binding site for CLC (show CLC Proteins) and on two additional and independent sites for CNTFRalpha (show CNTFR Proteins) and sorLA (show SORL1 Proteins), is a key player in CLC (show CLC Proteins) and CNTFRalpha (show CNTFR Proteins) signaling and turnover.
Article reports 11 novel mutations in CRLF1 expanding the mutational spectrum of CRLF1 in the Crisponi/cold-induced sweating type 1 syndrome to a total of 35 variants.
The mutation detected in CRLF1 has not been described in patients with CISS1, but in one with CS. These data seem to support the theory that CS and CISS1 are variants of the same disorder.
Data indicate that CRLF1 serves its protective role by a cell autonomous mechanism that is independent of the gp130 (show IL6ST Proteins)/JAK (show JAK3 Proteins) signaling pathway.
In idiopathic pulmonary fibrosis, CLF-1 is a selective stimulus of type II alveolar epithelial cells and may potentially drive an antifibrotic response by augmenting both T-helper-1-driven and T-regulatory-cell-driven inflammatory responses in the lung.
CRLF1 mutations showed that phenotypic severity of the two disorders: Crisponi syndrome (CS) and cold-induced sweating syndrome type 1 (CISS1) mainly depends on altered kinetics of secretion of the mutated CRLF1 protein.
Our data suggest that the CRLF1/CLC (show CLC Proteins) complex disrupts cartilage homeostasis and promotes the progress of OA by enhancing the proliferation of chondrocytes and suppressing the production of cartilage matrix
The p28 (show GSTO1 Proteins)/cytokine-like factor 1 (CLF) complex may participate in the regulation of natural killer (NK) and T cell functions by dendritic cells.
This gene encodes a member of the cytokine type I receptor family. The protein forms a secreted complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors. The complex can promote survival of neuronal cells. Mutations in this gene result in Crisponi syndrome and cold-induced sweating syndrome.
cytokine receptor-like factor 1
, class I cytokine receptor
, cytokine type 1 receptor CRLP-1
, cytokine-like factor 1
, cytokine receptor like molecule 3
, cytokine receptor-like molecule 3
, novel cytokine receptor 6