anti-Cytokine Receptor-Like Factor 2 (CRLF2) Antibodies

The protein encoded by CRLF2 is a receptor for thymic stromal lymphopoietin (TSLP). Additionally we are shipping CRLF2 Proteins (17) and CRLF2 Kits (11) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CRLF2 64109 Q9HC73
CRLF2 57914 Q8CII9
CRLF2 171499  
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Top anti-CRLF2 Antibodies at antibodies-online.com

Showing 10 out of 134 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-CRLF2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  721_B cell lysate WB Suggested Anti-CRLF2  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500  Positive Control:.21_B cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated CyTOF, FACS, WB Detection of TSLP R in Human PBMC Monocytes by Flow Cytometry. Human PBMC monocytes were stained with Human TSLP R Monoclonal Antibody. 500 μg Log in to see 8 to 9 Days
$397.76
Details
Mouse Goat Un-conjugated CyTOF, FACS, Neut, WB Detection of TSLP R in Mouse Splenocytes by Flow Cytometry. Mouse splenocytes were stained with Goat Anti-Mouse TSLP R Antigen Affinity-purified Polyclonal Antibody. Cell Proliferation Induced by TSLP and Neutralization by Mouse TSLP R Antibody. Recombinant Mouse TSLP. The ND50 is typically 0.2-0.6 ug/mL. 100 μg Log in to see 8 to 9 Days
$416.97
Details
Mouse Goat PE FACS Detection of TSLP R in Mouse Splenocytes by Flow Cytometry. Mouse splenocytes were stained with Goat Anti-Mouse TSLP R PE-conjugated Antigen Affinity-purified Polyclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$352.56
Details
Human Rabbit Un-conjugated IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
$478.50
Details
Human Rabbit Un-conjugated ELISA, IHC, IHC (p), WB Human Kidney (formalin-fixed, paraffin-embedded) stained with CRLF2 antibody ABIN461904 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Human Liver (formalin-fixed, paraffin-embedded) stained with CRLF2 antibody ABIN461904 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 0.05 mg Log in to see 11 to 14 Days
$484.00
Details
Human Mouse Un-conjugated FACS, Neut   100 μg Log in to see 15 to 18 Days
$222.56
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB   0.1 mg Log in to see 4 to 8 Days
$522.50
Details
Mouse Rabbit Un-conjugated EIA, WB   0.1 mg Log in to see 4 to 8 Days
$522.50
Details
Mouse Goat APC FACS Detection of TSLP R in Mouse Splenocytes by Flow Cytometry. Mouse splenocytes were stained with Goat Anti-Mouse TSLP R APC-conjugated Antigen Affinity-purified Polyclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$396.63
Details

Top referenced anti-CRLF2 Antibodies

  1. Human Monoclonal CRLF2 Primary Antibody for FACS, Neut - ABIN2689945 : Arima, Watanabe, Hanabuchi, Chang, Sun, Liu: Distinct signal codes generate dendritic cell functional plasticity. in Science signaling 2010 (PubMed)
    Show all 9 Pubmed References

  2. Human Monoclonal CRLF2 Primary Antibody for CyTOF, FACS - ABIN4899885 : Shan, Redhu, Saleh, Halayko, Chakir, Gounni: Thymic stromal lymphopoietin receptor-mediated IL-6 and CC/CXC chemokines expression in human airway smooth muscle cells: role of MAPKs (ERK1/2, p38, and JNK) and STAT3 pathways. in Journal of immunology (Baltimore, Md. : 1950) 2010 (PubMed)
    Show all 4 Pubmed References

  3. Mouse (Murine) Polyclonal CRLF2 Primary Antibody for FACS - ABIN4896188 : Oh, Oh, Yu, Myers, Leonard, Liu, Zhu, Zheng: IL-13 induces skin fibrosis in atopic dermatitis by thymic stromal lymphopoietin. in Journal of immunology (Baltimore, Md. : 1950) 2011 (PubMed)
    Show all 4 Pubmed References

  4. Mouse (Murine) Polyclonal CRLF2 Primary Antibody for CyTOF, FACS - ABIN4899486 : Osborn, Ryan, Kirchhof, Panoskaltsis-Mortari, Mortari, Tudor: Overexpression of murine TSLP impairs lymphopoiesis and myelopoiesis. in Blood 2004 (PubMed)
    Show all 4 Pubmed References

  5. Mouse (Murine) Polyclonal CRLF2 Primary Antibody for WB - ABIN541606 : Levin, Koelling, Friend, Isaksen, Ziegler, Perlmutter, Farr: Thymic stromal lymphopoietin: a cytokine that promotes the development of IgM+ B cells in vitro and signals via a novel mechanism. in Journal of immunology (Baltimore, Md. : 1950) 1999 (PubMed)
    Show all 3 Pubmed References

  6. Mouse (Murine) Polyclonal CRLF2 Primary Antibody for ELISA, WB - ABIN1003387 : Sims, Williams, Morrissey, Garka, Foxworthe, Price, Friend, Farr, Bedell, Jenkins, Copeland, Grabstein, Paxton: Molecular cloning and biological characterization of a novel murine lymphoid growth factor. in The Journal of experimental medicine 2000 (PubMed)
    Show all 4 Pubmed References

  7. Human Polyclonal CRLF2 Primary Antibody for IHC, ELISA - ABIN1003386 : Park, Martin, Garka, Gliniak, Di Santo, Muller, Largaespada, Copeland, Jenkins, Farr, Ziegler, Morrissey, Paxton, Sims: Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: Formation of a functional heteromeric complex requires interleukin 7 receptor. in The Journal of experimental medicine 2000 (PubMed)
    Show all 4 Pubmed References

  8. Human Polyclonal CRLF2 Primary Antibody for IHC (p), WB - ABIN2476989 : AuBuchon, Brightman: Use of indium-111 as a red cell label. in Transfusion 1989 (PubMed)
    Show all 2 Pubmed References

  9. Human Polyclonal CRLF2 Primary Antibody for ELISA, ICC - ABIN4363174 : Morshed, Yousefi, Stöckle, Simon, Simon: Thymic stromal lymphopoietin stimulates the formation of eosinophil extracellular traps. in Allergy 2012 (PubMed)

  10. Mouse (Murine) Polyclonal CRLF2 Primary Antibody for FACS - ABIN4896186 : Bao, Zhang, Yao, Lu, Tong, Yan, Tu, Yang, Zhou: Deguelin Attenuates Allergic Airway Inflammation via Inhibition of NF-κb Pathway in Mice. in International journal of biological sciences 2018 (PubMed)

More Antibodies against CRLF2 Interaction Partners

Human Cytokine Receptor-Like Factor 2 (CRLF2) interaction partners

  1. CRLF2 overexpression was observed in 14% (PHOP) and 16% (TARGET) of T-ALL patients. CRLF2 expression associates with stabilization of the intracellular domain of NOTCH1.

  2. Study results demonstrated that CRLF2 overexpression is associated with a poor prognosis in Bcell acute lymphoblastic leukemia (BALL), and the CRLF2/AKT/mTOR pathway is involved in the migration, invasion and chemotherapeutic agentinduced apoptosis of BALL cells.

  3. expression of CRLF2 was significantly increased in basophils of patients with allergic rhinitis after allergen stimulation

  4. Family-based whole genome analysis of a family with hereditary pulmonary alveolar proteinosis revealed a homozygous deletion that disrupts CSF2RA, CRLF2, and IL3RA gene in the pseudoautosomal region of the X chromosome in the affected child and one of asymptomatic siblings.

  5. TSLP expression on the basophil membrane of patients with severe asthma was not significantly different from healthy controls.

  6. high CRLF2 expression works with the IKZF1 deletion to drive oncogenesis of acute lymphoblastic leukemia

  7. this study shows that CRLF2 over-expression is a poor prognostic marker in children with high risk T-cell acute lymphoblastic leukemia

  8. data suggest that this high frequency of genetic aberrations in the context of a high CRLF2 expression could contribute to the high risk of relapse in P2RY8/CRLF2- and IGH/CRLF2-positive acute lymphoblastic leukemia.

  9. CRLF2 overexpression is associated with childhood B-cell acute lymphoblastic leukemia.

  10. CRLF2 gene rearrangement is associated with acute lymphoblastic leukemia.

  11. TSLPR levels were found to be significantly higher in asthmatic than in nonasthmatic children. TSLPR expression in non-allergic asthmatic and allergic asthmatic groups was found to be significantly higher than in non-allergic nonasthmatic group

  12. In adult B-cell acute lymphoblastic leukemia without recurrent fusion genes , high CRLF2 expression is associated with distinct clinico-biological features and an unfavourable prognosis

  13. CD4+ T cells from atopic dermatitis patients directly interacted with TSLP to produce a higher amount of IL-4 than those from normal subjects, and this action was attenuated with anti-TSLPR antibody

  14. The levels of mRNA for TSLP and TSLPR were significantly elevated in parotid gland tissues from the KD group as compared to the control group.

  15. Differences exist in the genetic profiles of Down syndrome-associated acute lymphoblastic leukemia patients in Japan and in Western countries, and that P2RY8-CRLF2 and EBF1 deletions may cooperate in leukemogenesis in a subset of Japanese DS-ALL patients.

  16. CRLF2 overexpression (OE) was detected in 30 (18%) of 167 patients, the P2RY8-CRLF2 fusion was identified in only 3 (1.8%) of 167 patients, all of which demonstrated CRLF2 OE.

  17. we report noncysteine in-frame mutations in IL7R and CRLF2 located in a region of the transmembrane domain closer to the cytosolic domain in acute lymphoblastic leukemias

  18. The TSLPR in blood plateltes promotes platelet activation via activating the PI3K/AKT pathway.

  19. both IKZF1 deletions and IGH@-CRLF2 are associated with an increased risk of treatment failure in adult acute lymphoblastic leukemia

  20. Data indicate that CD66c is frequently expressed in CRLF2-positive as well as hypodiploid cases.

Mouse (Murine) Cytokine Receptor-Like Factor 2 (CRLF2) interaction partners

  1. these results suggest that TSLP-TSLPR signaling is pivotal in the induction of nasal respiratory immunity against pathogenic pneumococcal infection

  2. A novel mouse xenograft model to study the role of TSLP-induced CRLF2 signals in normal and malignant human B lymphopoiesis has been developed.

  3. High-cholesterol diet increased TSLPR expression and atherosclerosis. High-dose ticagrelor moderated this trend. It modulated platelet activity and atherosclerosis mediated by TSLPR, potentially through the PI3K/Akt signal pathway.

  4. Activating thymic stromal lymphopoietin promotes atherosclerosis by inducing Th17/Treg imbalance through TSLPR signaling in a mouse model.

  5. Suggest that Treg defects in ApoE(-/-) mice might partially be attributed to the disruption of TSLP-TSLPR-LAP signaling in epithelial cells and dendritic cells.

  6. The structure of the mouse TSLP-mediated signaling complex reveals how TSLP establishes extensive interfaces with its cognate receptor (TSLPR).

  7. TSLPR helps to create a permissive microenvironment for the development and pulmonary metastasis of mammary carcinoma in a mouse model using implanted 4T1 tumour cells.

  8. A previously unrecognized role was found for TSLP/TSLPR signaling in type 2 immunity as an important enhancer for the development of alternately activated macrophages as well as for chemokine production.

  9. mice deficient in TSLP receptors on LCs abrogated the induction of OVA-specific IgE levels upon epicutaneous OVA sensitization.

  10. Increased susceptibility to autoimmune gastritis in thymic stromal lymphopoietin receptor-deficient mice.

  11. Presence of functional TSLP-specific receptor chain is required for the development of T helper cell type (Th)2 contact hypersensitivity to the hapten fluorescein isothiocyanate (FITC).

  12. Induced homodimerization of receptor chimeras containing the transmembrane and cytoplasmic domains of both human and mouse TSLP receptors is not sufficient for driving cell proliferation.

  13. expression pattern in antigen presenting cells

  14. B-cell development, including the IgM+ compartment, was unaffected by loss of the TSLPR pathway.

  15. molecular cloning of Tslpr in insect cells or COS cells resulted in expression of mTSLPR with an extracellular C-terminal end, a surprising result since the N-terminal region contains a signal sequence and two potential glycosylation sites

  16. local application of anti-TSLPR prevented Th2-mediated airway inflammation, at least partly, by regulating DCs function, which might be exploited to develop novel treatments for asthma.

CRLF2 Antigen Profile

Protein Summary

The protein encoded by this gene is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with CRLF2

  • cytokine receptor like factor 2 (CRLF2) antibody
  • cytokine receptor-like factor 2 (Crlf2) antibody
  • Crl2 antibody
  • CRLF2 antibody
  • CRLF2Y antibody
  • CRLM2 antibody
  • Ly114 antibody
  • Tpte2 antibody
  • Tslpr antibody

Protein level used designations for CRLF2

cytokine receptor-like factor 2 , IL-XR , P2RY8/CRLF2 fusion , TSLP receptor , cytokine receptor CRL2 precusor , cytokine receptor-like 2 , thymic stromal lymphopoietin protein receptor , thymic stromal lymphopoietin receptor , thymic stromal-derived lymphopoietin receptor , CRLM-2 , cytokine receptor-like molecule 2 , delta 1 , lymphocyte antigen 114 , thymic stromal-derived lymphopoietin, receptor , transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 , type I cytokine receptor delta 1

GENE ID SPECIES
491709 Canis lupus familiaris
529792 Bos taurus
749758 Pan troglodytes
100582238 Nomascus leucogenys
64109 Homo sapiens
57914 Mus musculus
171499 Rattus norvegicus
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