anti-Cytoskeleton Associated Protein 2 (CKAP2) Antibodies

Human Cytoskeleton Associated Protein 2 (CKAP2) interaction partners

1. High CKAP2 expression is associated with Ovarian Cancer.

2. Chromatin CKAP2 is an independent prognostic marker for relapse-free survival in early-stage breast cancer, and could potentially replace the mitotic activity index in clinical evaluation of proliferation activity.

3. The transcriptional activity of RHOA (show RHOA Antibodies), SEMA3B (show SEMA3B Antibodies), and CKAP2 genes was assessed in blood samples of leukaemia patients and healthy donors.

4. CKAP2 is involved in the maintenance of microtubule nucleation sites

5. GC box was responsible for the cyclic activity of human CKAP2 promoter through the phosphorylation of Sp1 (show PSG1 Antibodies), possibly by Cyclin A (show CCNA2 Antibodies)/Cdk (show CDK4 Antibodies) complex.

6. Findings suggest that the motif surrounding Ser627 ((625) RRSRRL (630)) is a critical for kinase-substrate recognition and for regulation of the subcellular localization of TMAP during mitosis.

7. TMAP is limited to pre-anaphase stages and suggest that the multiple phosphorylation may not act in concert but serve diverse functions.

8. CKAP2 comprises nine exons ranging 70-1442 bp and is about 22 kb in size (regulatory regions included). The CKAP2 promoter contains CCAAT (-39...-33) rather than the canonical TATA box, and harbors nine binding sites for six transcription factors

9. Data show that degradation of TMAP/CKAP2 during mitotic exit is mediated by the anaphase-promoting complex bound to Cdh1 (show CDH1 Antibodies) and that the KEN (show PCNT Antibodies) box motif near the N terminus is necessary for its destruction.

10. CKAP2 is a physiological substrate of anaphase-promoting complex (show CDC26 Antibodies)/cyclosome during mitotic exit and that a tight regulation of the CKAP2 protein level is critical for the normal mitotic progression.

Mouse (Murine) Cytoskeleton Associated Protein 2 (CKAP2) interaction partners

1. The results suggest that the phosphorylation of Cytoskeleton Associated Protein 2 (CKAP2) at T603 and possibly S608 phosphorylation sites by Cyclin Dependent Kinase 1 (CDK1 (show CDK1 Antibodies)) during mitosis is essential for maintaining the number of centrosomes.

2. we found that Lb1-null epicardial cells have a delayed nuclear morphology change in vivo, suggesting that Lb1 facilitates morphological changes associated with migration. These findings suggest that Lb1 contributes to nuclear shape maintenance and migration of epicardial cells

3. These data suggest a physiological role of CKAP2 in the formation of spindle bipolarity, which is necessary for maintaining chromosomal stability.

4. These findings suggest that CKAP2 is a new MAP with microtubule-stabilizing properties

5. Data suggest the existence of a functional positive feedback loop in which Ckap2 activates the G1 tetraploidy checkpoint and prevents aneuploidy.

6. The cellular functions of TMAP/CKAP2 might be regulated by timely phosphorylation and dephosphorylation during the course of mitosis.

7. Our present findings demonstrate that TMAP/CKAP2 is essential for proper chromosome segregation and for maintaining genomic stability.