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Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln).
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Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.
cytoplasmic tRNA 2-thiolation protein 1
, ATP binding domain 3
, ATP-binding domain-containing protein 3
, cancer-associated gene protein
, cancer-associated protein
, cytoplasmic tRNA adenylyltransferase 1
, cytosolic thiouridylase subunit 1 homolog