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DAZAP2 encodes a proline-rich protein which interacts with the deleted in azoospermia (DAZ) and the deleted in azoospermia-like gene through the DAZ-like repeats.
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methylation of DAZAP2 promoter was involved in downregulation of DAZAP2 in multiple myeloma cells.
In summary we established a new mechanism of IL17RB (show IL17RB ELISA Kits) regulation-Smurf2 (show SMURF2 ELISA Kits) dependent degradation of its adaptor protein DAZAP2.
Lys residues might play important roles in regulating the intracellular dynamics of the PRTB protein.K153 in human PRTB is essential for its ubiquitin-dependent degradation
DAZAP2 is downregulated in multiple myeloma samples and it may be a signal molecule (show WNT4 ELISA Kits) in multiple myeloma cells. DAZAP2 is involved in the pathogenesis of MM
Data indicate that TNF receptor associated factor 4 (TRAF4) recruited the E3-ligase SMURF2 (show SMURF2 ELISA Kits), to degrade the IL-25R-inhibitory molecule DAZ associated protein 2 (DAZAP2).
role as an immediate early (show JUN ELISA Kits), serum-responsive, and adhesion-inducible gene with possible involvement in cell cycle control, adhesion, and proliferation
This paper reveals that the mouse DAZAP2 homolog interacts with Sox6 and may be involved in the regulation of a cardiac L-type Ca2 (show CA2 ELISA Kits)+ channel.
This gene encodes a proline-rich protein which interacts with the deleted in azoospermia (DAZ) and the deleted in azoospermia-like gene through the DAZ-like repeats. This protein also interacts with the transforming growth factor-beta signaling molecule SARA (Smad anchor for receptor activation), eukaryotic initiation factor 4G, and an E3 ubiquitinase that regulates its stability in splicing factor containing nuclear speckles. The encoded protein may function in various biological and pathological processes including spermatogenesis, cell signaling and transcription regulation, formation of stress granules during translation arrest, RNA splicing, and pathogenesis of multiple myeloma. Multiple transcript variants encoding different isoforms have been found for this gene.
DAZ associated protein 2
, DAZAP2-like protein
, DAZ-associated protein 2
, deleted in azoospermia associated protein 2
, deleted in azoospermia-associated protein 2
, proline-rich transcript in brain
, proline-rich transcript, brain-expressed protein
, granule cell antiserum positive 28
, proline rich protein expressed in brain
, proline-rich protein expressed in brain