anti-DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) Antibodies

Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Additionally we are shipping DHX58 Kits (16) and DHX58 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DHX58 79132 Q96C10
DHX58 80861 Q99J87
DHX58 303538  
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Top anti-DHX58 Antibodies at antibodies-online.com

Showing 10 out of 104 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-DHX58 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  Human Spleen 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated ELISA, WB ABIN263162 (0.3µg/ml) staining of Human Liver lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$429.62
Details
Human Mouse Un-conjugated ELISA, FACS, WB Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng) Western blot analysis using DHX58 mAb against human DHX58 (AA: 479-678) recombinant protein. (Expected MW is 48.7 kDa) 0.1 mg Log in to see 8 to 11 Days
$561.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: DHX58 Antibody [NBP1-85348] - Staining of human cell line U-2 OS shows positivity in cytoplasm. Immunohistochemistry-Paraffin: DHX58 Antibody [NBP1-85348] - Immunohistochemical staining of human kidney shows distinct cytoplasmic positivity in cells in tubules. 0.1 mL Log in to see 10 to 13 Days
$491.63
Details
Human Goat Un-conjugated ELISA, WB 100 μg Log in to see 7 to 9 Days
$610.50
Details
Human Rabbit Un-conjugated IHC (p), WB DHX58 Antibody (N-term)(ABIN651621) western blot analysis in A549 cell line lysates (35 µg/lane). This demonstrates the DHX58 antibody detected the DHX58 protein (arrow). DHX58 Antibody (N-term) (ABIN651621) immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$335.50
Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of HEK-293 cells, using LGP2 antibody. ABIN6273262 at 1/100 staining Human pancreas cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL Log in to see 11 to 12 Days
$390.77
Details
Bat Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated EIA, WB   0.1 mg Log in to see 8 to 11 Days
$474.10
Details
Human Rabbit Un-conjugated EIA, WB   0.1 mg Log in to see 8 to 11 Days
$474.10
Details

Top referenced anti-DHX58 Antibodies

  1. Human Polyclonal DHX58 Primary Antibody for ELISA, WB - ABIN1002730 : Yoneyama, Kikuchi, Natsukawa, Shinobu, Imaizumi, Miyagishi, Taira, Akira, Fujita: The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. in Nature immunology 2004 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal DHX58 Primary Antibody for ELISA, WB - ABIN1002731 : Andrejeva, Childs, Young, Carlos, Stock, Goodbourn, Randall: The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter. in Proceedings of the National Academy of Sciences of the United States of America 2004 (PubMed)
    Show all 4 Pubmed References

  3. Human Polyclonal DHX58 Primary Antibody for ELISA, WB - ABIN1002729 : Akira, Uematsu, Takeuchi: Pathogen recognition and innate immunity. in Cell 2006 (PubMed)
    Show all 4 Pubmed References

  4. Human Polyclonal DHX58 Primary Antibody for WB - ABIN2475326 : Raz, Torres, Acker: Age-related shrinkage of the mamillary bodies: in vivo MRI evidence. in Neuroreport 1992 (PubMed)
    Show all 3 Pubmed References

  5. Human Polyclonal DHX58 Primary Antibody for ELISA, WB - ABIN449720 : Saito, Hirai, Loo, Owen, Johnson, Sinha, Akira, Fujita, Gale: Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2. in Proceedings of the National Academy of Sciences of the United States of America 2007 (PubMed)

  6. Human Polyclonal DHX58 Primary Antibody for ICC, IF - ABIN4305195 : Sanchez David, Combredet, Sismeiro, Dillies, Jagla, Coppée, Mura, Guerbois Galla, Despres, Tangy, Komarova: Comparative analysis of viral RNA signatures on different RIG-I-like receptors. in eLife 2016 (PubMed)

More Antibodies against DHX58 Interaction Partners

Rainbow Trout (Oncorhynchus mykiss) DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) interaction partners

  1. MDA5 (show IFIH1 Antibodies) and LGP2 act as independent positive regulators of the IFN response in fish. the LGP2 variant with a deletion of 54 amino acids at the C terminus acts as a negative regulator for LGP2-elicited antiviral signaling.

Human DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) interaction partners

  1. Study demonstrated a tumor suppressor role of LGP2 in neuroblastoma (show ARHGEF16 Antibodies) (NB). LGP2 was effective in promoting poly (I:C)-induced NB suppression and cytoplasmic LGP2 can serve as an independent favorable prognostic factor in NB patients.

  2. genetic loss of LGP2 uncovers dsRNA-mediated RNAi albeit less strongly than complete loss of the IFN system

  3. Results indicate that pumilio RNA binding family member 1 (PUM1 (show PUM1 Antibodies)) is a negative regulator of RNA helicase LGP2 (LGP2), a master regulator of innate immunity genes expressed in a cascade fashion.

  4. study documents that recombinant measles virus produce defective interfering genomes that have high immunostimulatory properties via their binding to RIG-I (show DDX58 Antibodies) and LGP2 proteins, both of which are cytosolic nonself RNA sensors of innate immunity.

  5. Data support a new model where an LGP2-MDA5 oligomer shuttles NS3 to the mitochondria to block antiviral signaling

  6. essential role in activating interferon signaling against hepatitis C virus (HCV) infection by promoting MDA5 (show IFIH1 Antibodies) recognition of HCV pathogen-associated molecular patterns

  7. This review briefly summarizes the RLR system, and focuses on the relationship between LGP2 and MDA5 (show IFIH1 Antibodies), describing in detail how these two proteins work together to detect foreign RNA and generate a fully functional antiviral response.

  8. L region antisense RNA of EMCV is a key determinant of innate immunity to the virus and represents an RNA that activates LGP2 associated MDA5 (show IFIH1 Antibodies) in virally-infected cells.

  9. LGP2 did not reveal significant single-SNP associations with multiple sclerosis risk.

  10. LGP2 increases the initial rate of MDA5 (show IFIH1 Antibodies)-RNA interaction and regulates MDA5 (show IFIH1 Antibodies) filament assembly.

Mouse (Murine) DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) interaction partners

  1. PACT (show RBBP6 Antibodies) interacts with LGP2 and this interaction is enhanced by encephalomyocarditis virus (EMCV) infection. In vitro interaction analyses using purified recombinant proteins confirmed that the single-stranded Theiler's murine encephalitis virus genome enhanced the interaction between LGP2 and PACT (show RBBP6 Antibodies).

  2. L region antisense RNA of EMCV is a key determinant of innate immunity to the virus and represents an RNA that activates LGP2 associated MDA5 (show IFIH1 Antibodies) in virally-infected cells.

  3. This in vivo study reveals that LGP2 is a major downregulator of the influenza A virus-triggered detrimental inflammatory response.

  4. Enhanced expression of LGP2 suppresses the IFN stimulated genes associated with cytotoxic stress by turning off the expression of IFNbeta

  5. LGP2, a host protein induced during influenza A virus infection, downregulates the host antiviral IFN response

  6. LGP2 promotes an essential prosurvival signal in response to antigen stimulation to confer CD8 (show CD8A Antibodies)+ T cell-number expansion and effector functions against divergent RNA viruses, including West Nile virus and lymphocytic choriomeningitis virus.

  7. findings demonstrate a regulatory role for LGP2 in the response to cytosolic DNA, an intracellular bacterial pathogen, and a DNA virus, and provide a plausible mechanistic hypothesis as the basis for this activity

  8. data suggest that LGP2 facilitates viral RNA recognition by RIG-I (show DDX58 Antibodies) and MDA5 (show IFIH1 Antibodies) through its ATPase (show DNAH8 Antibodies) domain.

  9. Lgp2 acts as a negative feedback regulator of antiviral signaling by sequestering double-stranded RNA from retinoic acid-inducible gene-I (RIG-I (show DDX58 Antibodies)).

  10. Functional analysis of the human LGP2 ortholog.

Pig (Porcine) DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) interaction partners

  1. Study indicates that DHX58 is an important gene that is associated with the immune response in swine.

Cow (Bovine) DEXH (Asp-Glu-X-His) Box Polypeptide 58 (DHX58) interaction partners

  1. Functional analysis of the human LGP2 ortholog.

DHX58 Antigen Profile

Protein Summary

Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1- dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate.

Gene names and symbols associated with DHX58

  • DEXH-box helicase 58 L homeolog (dhx58.L) antibody
  • DExH-box helicase 58 (DHX58) antibody
  • DExH-box helicase 58 (dhx58) antibody
  • probable ATP-dependent RNA helicase DHX58 (LOC100566102) antibody
  • DEXH (Asp-Glu-X-His) box polypeptide 58 (dhx58) antibody
  • DEXH (Asp-Glu-X-His) box polypeptide 58 (Dhx58) antibody
  • DEXH-box helicase 58 (Dhx58) antibody
  • B430001I08Rik antibody
  • D11LGP2 antibody
  • D11Lgp2e antibody
  • DHX58 antibody
  • Lgp2 antibody
  • LPG2 antibody
  • MGC82787 antibody
  • RGD1310093 antibody
  • RLR-3 antibody

Protein level used designations for DHX58

DEXH (Asp-Glu-X-His) box polypeptide 58 , probable ATP-dependent RNA helicase DHX58 , probable ATP-dependent RNA helicase DHX58-like , Probable ATP-dependent RNA helicase DHX58 , RIG-I-like receptor 3 , RIG-I-like receptor LGP2 , RLR , RNA helicase LGP2 , ortholog of mouse D11lgp2 , probable ATP-dependent helicase LGP2 , protein D11Lgp2 homolog , RIG-I-like receptor Lgp2 , protein D11Lgp2 , ATP-dependent RNA helicase DHX58

GENE ID SPECIES
444342 Xenopus laevis
742679 Pan troglodytes
100012544 Monodelphis domestica
100066316 Equus caballus
100171435 Pongo abelii
100403680 Callithrix jacchus
100468505 Ailuropoda melanoleuca
100499613 Oncorhynchus mykiss
100566102 Anolis carolinensis
100195148 Salmo salar
79132 Homo sapiens
80861 Mus musculus
303538 Rattus norvegicus
607803 Canis lupus familiaris
100524520 Sus scrofa
508378 Bos taurus
101121528 Ovis aries
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