DIRAS Family, GTP-Binding RAS-Like 3 Proteins (DIRAS3)

DIRAS3 is a member of the ras superfamily, and is expressed in normal ovarian and breast epithelial cells, but not in ovarian and breast cancers. Additionally we are shipping DIRAS3 Antibodies (39) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DIRAS3 9077 O95661
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Top DIRAS3 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
Human Cells Human Fc Tag 100 μg Log in to see 20 to 21 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days

DIRAS3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,

Top referenced DIRAS3 Proteins

  1. Human DIRAS3 Protein expressed in HEK-293 Cells - ABIN2719498 : Zhang, Lu, Mao, Ahmed, Yang, Zhou, Jennings, Rodriguez-Aguayo, Lopez-Berestein, Miranda, Qiao, Baladandayuthapani, Li, Sood, Liu, Le, Bast: CDK5 Regulates Paclitaxel Sensitivity in Ovarian Cancer Cells by Modulating AKT Activation, p21Cip1- and p27Kip1-Mediated G1 Cell Cycle Arrest and Apoptosis. in PLoS ONE 2015 (PubMed)

More Proteins for DIRAS Family, GTP-Binding RAS-Like 3 (DIRAS3) Interaction Partners

Pig (Porcine) DIRAS Family, GTP-Binding RAS-Like 3 (DIRAS3) interaction partners

  1. polymorphism-based approach was used to detect the imprinting status of NNAT (show NNAT Proteins) and DIRAS3 genes in five heterozygous pigs (based on SNP) of Large White and Meishan F(1) hybrids

Human DIRAS Family, GTP-Binding RAS-Like 3 (DIRAS3) interaction partners

  1. lncRNA GAS5 functions as a competing endogenous RNA for miR (show MLXIP Proteins)-221 to suppress cell growth and EMT (show ITK Proteins) in osteosarcoma by regulating the miR (show MLXIP Proteins)-221/ARHI pathway.

  2. DiRas3 binds to KSR1 (show KSR1 Proteins) independently of its interaction with activated Ras and RAF (show RAF1 Proteins).

  3. We demonstrate that DIRAS3 knock-down (KD) in adipose stromal/progenitor cells (ASCs) induces activation of Akt (show AKT1 Proteins)-mTOR (show FRAP1 Proteins) signaling and proliferation arrest. DIRAS3 KD ASCs lose the potential to form colonies and are negative for Ki-67 (show MKI67 Proteins). Moreover, silencing of DIRAS3 results in a premature senescence phenotype.

  4. ARHI-mediated up-regulation of glycolysis and glutaminolysis was found to be autophagy-dependent and inhibition of these metabolic pathways resulted in decreased cell viability.

  5. The overexpression of ARHI promotes colon cancer SW480 cell apoptosis by inhibiting the level of Akt (show AKT1 Proteins).

  6. Transcriptional, but not post-transcriptional, silencing of GNG12-AS1 (show PTGDR Proteins) causes concomitant upregulation of DIRAS3, indicating a function in transcriptional interference.

  7. ARHI mRNA and protein expression is markedly decreased in osteosarcoma MG-63 cells lines. Overexpression of ARHI inhibits cell viability and proliferation.

  8. ARHI-mediated autophagy-associated cell death enhances chemosensitivity to cisplatin in ovarian cancer cell lines and xenografts.

  9. EZH2 (show EZH2 Proteins)-''induced H3K27me3 is associated with epigenetic repression of the ARHI tumor-suppressor gene in epithelial ovarian cancer

  10. ARHI competes with RanGTPase and interacts with importin beta (show KPNB1 Proteins) via basic-acidic patch interaction, which leads to inhibition of STAT3 (show STAT3 Proteins) translocation.

DIRAS3 Protein Profile

Protein Summary

This gene is a member of the ras superfamily, and is expressed in normal ovarian and breast epithelial cells, but not in ovarian and breast cancers. It is an imprinted gene, with monoallelic expression of the paternal allele, which is associated with growth suppression. Thus, this gene appears to be a putative tumor suppressor gene whose function is abrogated in ovarian and breast cancers.

Gene names and symbols associated with DIRAS3

  • DIRAS family GTPase 3 (DIRAS3)
  • DIRAS family GTP binding RAS like 3 (diras3)
  • ARHI protein
  • DIRAS3 protein
  • NOEY2 protein

Protein level used designations for DIRAS3

DIRAS family, GTP-binding RAS-like 3 , GTP-binding protein Di-Ras3 , GTP-binding RAS-like protein 3 , distinct subgroup of the Ras family member 3 , ras homolog gene family, member I , rho-related GTP-binding protein RhoI

456930 Pan troglodytes
504559 Bos taurus
701273 Macaca mulatta
733668 Sus scrofa
100135197 Xenopus (Silurana) tropicalis
100147791 Ovis aries
9077 Homo sapiens
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