DKK3 ELISA Kits

Human DKK3 interaction partners

1. CKAP4 has a role in esophageal cancer cell proliferation through p63 dependent DKK3 expression

2. Dickkopf-3 (DKK3) is produced by pancreatic stellate cells and is present in most human pancreatic ductal adenocarcinoma.

3. Median urinary DKK3-to-creatinine concentration at baseline was significantly higher in patients with chronic kidney disease (CKD) than the general population sample (431 versus 33 pg/mg). In the CKD cohort, having a urinary DKK3-to-creatinine level >4000 pg/mg was independently and significantly associated after multiple adjustments with mean annual decline in eGFR of 7.6% over 12 months.

4. Compared with control cells, head and neck squamous cell carcinoma (HNSCC) Dickkopfrelated protein 3 (DKK3) knockdown cells exhibit significantly reduced proliferation, migration and invasion, and formed significantly smaller tumor masses when subcutaneously transplanted into nude mice. DKK3 overexpression in HSC3 shDKK3 cells rescues cellular proliferation, migration and invasion.

5. Dkk3 expression might be employed as a potential marker to indicate carcinogenesis and histogenesis, even prognosis.

6. These observations are consistent with a model in which the loss of Dkk-3 in prostate cancer leads to increased secretion of TGFBI and ECM-1, which have tumor-promoting and tumor-protective roles, respectively

7. Dickkopf-3 (DKK3) is a heat shock transcription factor 1 protein (HSF1) effector that modulates the pro-tumorigenic behaviour of cancer-associated fibroblasts (CAFs), and DKK3 orchestrates a concomitant activation of beta-catenin and YAP oncogene protein (YAP)/tafazzin protein (TAZ).

8. DKK3 altered the atherosclerotic plaque content by increasing smooth muscle cell differentiation/numbers and reducing vascular inflammation.

9. These findings suggested that the down-regulated REIC expression might be involved in lung carcinogenesis due to its promoter methylation

10. the results indicate that TNFalpha downregulates REIC/Dkk3 expression in normal skin keratinocytes.

11. These results show that miR-25-3p has intracellular and extracellular oncogenic functions as well as clinicopathological relevance in osteosarcoma, indicating its potential as a novel diagnostic and therapeutic tool for the clinical management of this disease.

12. DKK3 might contribute to cellular proliferation, invasion, migration, and tumor cell survival in head and neck/oral squamous cell carcinoma cells through a mechanism other than the canonical Wnt signaling pathway, which might be attributed to PI3K-Akt signaling

13. this study demonstrated the anti-glioma effect of Ad-SGE-REIC, which may represent a promising strategy for the treatment of malignant glioma.

14. DKK3 is a novel and promising molecular target for keloid treatment.

15. This report demonstrates that GATA4 promotes oncogenesis by inhibiting miR125b-dependent suppression of DKK3 expression. This GATA4/miR125b/DKK3 axis may be a major regulator of growth, migration, invasion, and survival in hepatoma cells.

16. dickkopf-3 (Dkk-3) is a tumor suppressor gene that is downregulated in various cancers.

17. Study shows a reduced expression of DKK3 in adrenocortical carcinoma potentially contributing to adrenal dedifferentiation and/or progression of malignancy.

18. Low DKK3 expression is associated with gastric cancer.

19. studies decoding the underlying molecular mechanisms of DKK3-mediated effects may help to identify novel targeted therapies for this clinically highly relevant breast cancer subtype

20. REIC/Dkk-3 could be involved early in squamous cell carcinoma development and have inhibitory effect on the development of SCC

Mouse (Murine) DKK3 interaction partners

1. Dkk3 binds to CXCR7 and enhances vascular progenitor cells cell migration and vascular regeneration.

2. DKK3 overexpression substantially alleviated AngII infusion-induced cardiac hypertrophy and fibrosis by regulating ADAM17/ACE2 pathway activity and inhibiting the GSK-3beta/beta-catenin pathway.

3. DKK3 altered the atherosclerotic plaque content by increasing smooth muscle cell differentiation/numbers and reducing vascular inflammation.

4. findings suggest that Dkk3 may be used as diagnostic marker and as therapeutic target for age-related muscle atrophy, and reveal a distinct transcriptional control of Fbxo32 and Trim63

5. The data of this study suggest that Dkk3 is an agonist of Wnt signaling, and the ability of transgenic expression of Dkk3 to compensate for the decrease in Dkk3 expression in AD mice, reverse dysfunctional Wnt signaling, and partially inhibit the pathological development of AD suggests that Dkk3 could serve as a therapeutic target for the treatment of AD.

6. DKK3 expression in macrophages is involved in the pathogenesis of atherosclerosis through modulation of inflammation and inactivation of the Wnt/beta-catenin pathway.

7. DKK3 deficiency accelerated atherosclerosis and delayed re-endothelialization and exacerbated neointima formation.

8. These results suggest that Dkk3 has pleiotropic roles for a secretory glycoprotein that acts primarily in the gastrointestinal tract, thymus, endocrine and reproductive organs of the mouse.

9. these data suggest that downregulation of tubular beta-catenin signaling induced by Dkk-3 has a detrimental role in chronic proteinuria, partially through the increase in apoptosis.

10. Dkk3 expression was seen in the superficial zone of the mandibular condyle cartilage.

11. Studied role of Dkk3 on the pathogenesis of familial dilated cardiomyopathy, and whether and how Dkk3 interferes with Wnt signaling in heart tissues.

12. the soluble DKK3 protein might be a promising new agent for the improvement of current protocols for the directed differentiation of pluripotent and multipotent stem cells

13. DKK3 induces stem cell differentiation into smooth muscle lineage via ATF6 signaling and myocardin expression.

14. Date indicate that B1 cells have a better survival and proliferation capacity in the absence of Dickkopf-3 protein (DKK3).

15. DKK3 acts as a cardioprotective regulator of pathological cardiac hypertrophy

16. This is the first report of role of DKK3 in the testis and DKK3 mediated regulation of spermatogenesis via WNT-4/beta-CATENIN modulation.

17. Findings suggest that Dkk-3 maintains the structural integrity of the prostate gland by limiting TGF-beta/Smad signalling.

18. Dkk3 can act as a modifier gene in a mouse model for altered potassium channel function and suggest its potential involvement in human PA syndromes.

19. The precise expression of the Dkk3 protein was examined by generating transgenic mice that express EGFP integrated into the Dkk3 gene in a bacterial artificial chromosome plasmid.

20. abrogation of DKK3 function reversed tolerance, leading to eradication of tumors expressing the target antigen and to rejection of autologous skin grafts. Thus, our findings define DKK3 as a immune modulator with a crucial role for CD8 T-cell tolerance