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DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Additionally we are shipping DNA (Cytosine-5)-Methyltransferase 1 Kits (31) and DNA (Cytosine-5)-Methyltransferase 1 Proteins (10) and many more products for this protein.
Showing 10 out of 554 products:
Human Monoclonal DNMT1 Primary Antibody for ChIP, CyTOF - ABIN252481
Dennis, Fan, Geiman, Yan, Muegge: Lsh, a member of the SNF2 family, is required for genome-wide methylation. in Genes & development 2001
Show all 106 Pubmed References
Human Monoclonal DNMT1 Primary Antibody for ChIP, IP - ABIN2668504
Schnekenburger, Talaska, Puga: Chromium cross-links histone deacetylase 1-DNA methyltransferase 1 complexes to chromatin, inhibiting histone-remodeling marks critical for transcriptional activation. in Molecular and cellular biology 2007
Show all 4 Pubmed References
Human Polyclonal DNMT1 Primary Antibody for DB, ELISA - ABIN4369817
Saito, Kanai, Nakagawa, Sakamoto, Saito, Ishii, Hirohashi: Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas. in International journal of cancer. Journal international du cancer 2003
Show all 3 Pubmed References
Human Polyclonal DNMT1 Primary Antibody for WB - ABIN387879
Peterson, Bögler, Taylor: p53-mediated repression of DNA methyltransferase 1 expression by specific DNA binding. in Cancer research 2003
Show all 7 Pubmed References
Human Polyclonal DNMT1 Primary Antibody for FACS, WB - ABIN387878
Leu, Rahmatpanah, Shi, Wei, Liu, Yan, Huang: Double RNA interference of DNMT3b and DNMT1 enhances DNA demethylation and gene reactivation. in Cancer research 2003
Show all 7 Pubmed References
Human Polyclonal DNMT1 Primary Antibody for IHC (p), IHC - ABIN314281
Nanduri, Makarenko, Reddy, Yuan, Pawar, Wang, Khan, Zhang, Kinsman, Peng, Kumar, Fox, Godley, Semenza, Prabhakar: Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis. in Proceedings of the National Academy of Sciences of the United States of America 2012
Show all 2 Pubmed References
Human Polyclonal DNMT1 Primary Antibody for EIA - ABIN358462
Liao, Siu, Chan, Wong, Ngan, Chan, Li, Khoo, Cheung: Hypermethylation of RAS effector related genes and DNA methyltransferase 1 expression in endometrial carcinogenesis. in International journal of cancer. Journal international du cancer 2008
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Human Polyclonal DNMT1 Primary Antibody for EIA - ABIN358447
Yang, Andrade, Labialle, Moussette, Geneau, Sinnett, Belisle, Greenwood, Naumova: Parental effect of DNA (Cytosine-5) methyltransferase 1 on grandparental-origin-dependent transmission ratio distortion in mouse crosses and human families. in Genetics 2008
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Human Polyclonal DNMT1 Primary Antibody for IF (p), IHC (p) - ABIN671796
Khan, Tania, Wei, Mei, Fu, Cheng, Xu, Fu: Thymoquinone inhibits cancer metastasis by downregulating TWIST1 expression to reduce epithelial to mesenchymal transition. in Oncotarget 2015
Human Polyclonal DNMT1 Primary Antibody for IF (p), IHC (p) - ABIN757717
Tan, Xu, Zeisberg, Zeisberg: High inorganic phosphate causes DNMT1 phosphorylation and subsequent fibrotic fibroblast activation. in Biochemical and biophysical research communications 2016
Dnmt1 stability requires UHRF1 (show UHRF1 Antibodies) phosphorylation and that crosstalk between the proteins is essential for the function of these two important epigenetic regulators during gastrulation
Lsh (show HELLS Antibodies) Is Essential for Maintaining Global DNA Methylation (show HELLS Antibodies) Levels in Amphibia and Fish and Interacts Directly with Dnmt1.
Dnmt1 is required for hematopoietic stem and progenitor cells maintenance via cebpa (show CEBPA Antibodies) regulation during definitive hematopoiesis in zebrafish
These data provide the first evidence that Uhrf1 (show UHRF1 Antibodies) and Dnmt1 function is required for vertebrate lens development and maintenance.
These results suggest that Dnmt1 activity helps direct histone methylation by Suv39h1 (show SUV39H1 Antibodies) and that, together, Dnmt1 and Suv39h1 (show SUV39H1 Antibodies) help guide the terminal differentiation of particular tissues.
Data show that in dnmt1 homozygous mutants, reactivation of gfp expression occurs in a reproducible subset of cells, raising the possibility of different sensitivities or alternative silencing mechanisms in discrete cell populations.
Thus, our data suggest that Dnmt1 is dispensable for pancreatic duct or endocrine cell formation, but not for acinar cell survival. In addition, Dnmt1 may influence the differentiation of pancreatic beta cell progenitors.
DNMT1 is associated with cell cycle and DNA replication gene sets in diffuse large B-cell lymphoma
both messenger RNA and protein levels of KLF2 (show KLF2 Antibodies) in HUVEC co-treated with LPS (show IRF6 Antibodies) and DNA methyltransferase (DNMT) 1 small interfering RNA were dramatically higher than that treated with LPS (show IRF6 Antibodies) only.
By perturbing BCL11A (show BCL11A Antibodies)-DNMT1 interaction, miR (show MLXIP Antibodies)-137 impairs cancer stemness and suppresses tumor development in Triple negative breast cancer.
DNMT3B (show DNMT3B Antibodies) rs1569686 gene polymorphism in women might be a genetic marker for the susceptibility to recurrent spontaneous abortion
we demonstrated that the downregulation of CLDN6 (show CLDN6 Antibodies) is regulated through promoter methylation by DNMT1, which depends on the SMAD2 (show SMAD2 Antibodies) pathway, and that CLDN6 (show CLDN6 Antibodies) is a key regulator in the SMAD2 (show SMAD2 Antibodies)/DNMT1/CLDN6 (show CLDN6 Antibodies) pathway to inhibit EMT (show ITK Antibodies), migration and invasion of breast cancer cells
GNAO1 (show GNAO1 Antibodies) transcription was inhibited by promoter hypermethylation, contributing to its low expression. It was further revealed that the silencing effect was regulated by methyltransferase 1 (DNMT1), and was further enhanced by transforming growth factor beta (TGF-beta).
These results demonstrate that targeting NFkappaB (show NFKB1 Antibodies)/PDL1 (show CD274 Antibodies)/STAT3 (show STAT3 Antibodies)/DNMT1 axis is a new therapeutic strategy for preventing or overcoming the acquired resistance to sorafenib in hepatocellular carcinoma (HCC (show FAM126A Antibodies))patients
PPI decreased expression of DNMT1. Silenced HOTAIR reduced DNMT1 protein expression. Exogenously expressed HOTAIR resisted PPI-inhibited DNMT1 protein expression. Excessive EZH2 (show EZH2 Antibodies) antagonized PPI-suppressed DNMT1 protein expression or vice versa. The interactions among HOTAIR, DNMT1 and EZH2 (show EZH2 Antibodies), and reciprocal regulation of DNMT1 and EZH2 (show EZH2 Antibodies) contribute to the overall responses of PPI.
Epigenetic enhancement of the post-replicative DNA mismatch repair of mammalian genomes by a Hemi-(m)CpG-Np95 (show UHRF1 Antibodies)-Dnmt1 axis has been demonstrated for humans and mice.
DNMT1 is predictive of diffuse large B-cell lymphomas (DLBCLs) patients' survival, and suggest that DNMT1 could be a DLBCL therapeutic target due to its significant association with Ki-67 (show MKI67 Antibodies).
Dnmt1 was indispensable for oocyte cytoplasmic maturation, providing a novel role for Dnmt1 in the regulation of oocyte maturation.
Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1, Dnmt3a (show DNMT3A Antibodies), Hdac1 (show HDAC1 Antibodies), Kdm3a (show KDM3A Antibodies) and Uhrf1 (show UHRF1 Antibodies) were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).
DNMT1o is localized mainly in the nuclei of oocytes and early embryos, whereas DNMT1s is expressed in the ooplasm (show NLRP5 Antibodies) cortex of oocytes and cytoplasm of early embryos.
results indicate that loss of Dnmt1 in the maternal nucleus during SCNT significantly contributes to the unfaithful maintenance of methylation imprints in cloned embryos
Oocyte-specific Dnmt1 is cytoplasmic during early development.
Dnmt1 mRNA abundance plays an important role during protein regulation, Dnmt1 enzyme is mainly posttranscriptionally regulated.
DNMT1 silencing significantly decreased the methylation levels of miR (show MYLIP Antibodies)-29b promoter, up-regulated miR (show MYLIP Antibodies)-29b expression and inhibited bovine viral diarrhea virus replication.
Through down-regulating the expression of DNMT1, miR (show MYLIP Antibodies)-152 reduced Global DNA methylation (show HELLS Antibodies) and the activity of DNMT to reactivate the lactation signal transduction genes Akt (show AKT1 Antibodies) and Ppar gamma (show PPARG Antibodies).
More DNMT1 mRNA was detected in the transgenic somatic cell nuclear transfer (SCNT) group than the other three groups. Hsp 70.1 mRNA was detected in the in vitro fertilzation embryos. Mash2 (show ASCL2 Antibodies) mRNA was present at highest levels in transgenic SCNT embryos.
Our results indicate an essential role for Dnmt1 during bovine preimplantation development (show MTA2 Antibodies), and suggest proper transcriptional reprogramming of this gene family in SCNT embryos.
Dnmt1 is retained in the cytoplasm in metaphase II stage oocytes and zygotes, it enters the nuclei of 8-16 cell stage embryos
Abnormal gene expression of DNMT, INFT, and MHC1 was noted in the majority of cloned embryos, indicating inefficient nuclear reprogramming and retarded embryo development.
Results describe the alternative splicing and expression analysis of bovine DNA methyltransferase 1.
Report inhibition of DNA methyltransferase 1 expression in bovine fibroblast cells used for nuclear transfer.
The findings reveal that MET1-mediated shoot regeneration is regulated by the cytokinin-induced cell cycle, and provide new insights into the regulation of DNA methylation (show HELLS Antibodies) in shoot regeneration.
Long-term stability and epigenetic features differ for individual loci. Our data show that over-expression of MET1, and potentially of other genes encoding epigenetic factors, offers an alternative strategy to identify epigenetic target genes and to create novel epi (show TFPI Antibodies)-alleles
MET1 confines ARID1 to the vegetative cell of male gametes, but ARID1 conversely represses MET1 in the central cell of female gametes.
MET1 is a thylakoid-associated TPR protein involved in photosystem II supercomplex formation and repair in Arabidopsis
Met1 gene expression throughout normal development, particularly in the flower
MET1 is a contributor to epigenetic diversity in Arabidopsis.
VIM (show VIM Antibodies) proteins regulate genome-wide epigenetic gene silencing through coordinated modulation of DNA methylation (show HELLS Antibodies) and histone modification status in collaboration with MET1
VIM (show VIM Antibodies) proteins function in transcriptional regulation via their roles in the MET1 DNA methylation (show HELLS Antibodies) pathway.
Genetic studies indicate that the Polycomb (show CBX2 Antibodies) Repressive Complex 2 (PRC2) but not the DNA METHYLTRANSFERASE1 (MET1) is involved in regulating imprinted expression in the embryo. [MET1]
MET1 restores body methylation, which is region-specific but random with respect to the affected CG sites, and is moderately although not decisively influenced by transcription.
Increased shear stress without a change in flow direction initiates arteriogenic growth; however, it also elicits DNMT1-dependent endothelial cells DNA hypermethylation. In turn, this diminishes mechanosensing, augments shear stress set point, and constrains the ultimate arteriogenic capacity of the vessel.
Single-cell transcriptome analysis detected Dnmt1 expression in murine migratory GABAergic embryonic preoptic area (POA)-derived cells. Deletion of Dnmt1 in postmitotic immature cells of the POA caused defective migration and severely diminished adult cortical interneuron numbers. DNMT1 preserves the migratory shape in part through negative regulation of Pak6 (show PAK6 Antibodies), which stimulates neuritogenesis postmigration.
The aim of the present study is to investigate spatial and temporal expression levels and subcellular localizations of the DNMT1, DNMT3A (show DNMT3A Antibodies), and DNMT3B (show DNMT3B Antibodies) proteins in the mouse germinal vesicle (GV) and metaphase II (MII) oocytes, and early embryos from 1-cell to blastocyst stages.
DNMT1 ablation from kidney proximal tubules enhanced cisplatin-induced acute kidney injury in mice, suggesting a renoprotective role of DNA methylation (show HELLS Antibodies).
We show that expression of Id-1 (show IDH1 Antibodies), a negative regulator of myogenesis, is enhanced in Dnmt1-deficient cultures, leading to enhanced transdifferentiation of myoblasts toward the osteogenic lineage. Thus, these studies demonstrate that Dnmt1 influences cellular identity and determines lineage fidelity.
this study shows that DNMT1 might directly repress p53 (show TP53 Antibodies), at least in part, by binding to the p53 (show TP53 Antibodies) promoter locus
Knockdown of DNMT3A (show DNMT3A Antibodies) or DNMT1 protected neurons against mutant Htt (show HTT Antibodies)-induced toxicity, together demonstrating a requirement for DNMTs in mutant Htt (show HTT Antibodies)-triggered neuronal death and suggesting a neurodegenerative mechanism based on DNA methylation (show HELLS Antibodies)-mediated transcriptional repression.
Sp1 (show SP1 Antibodies)/NFkappaB p65 (show NFkBP65 Antibodies)-Dnmt1 pathway may be exploited as a therapeutic target for protecting against podocyte injury in diabetic nephropathy.
2-hydroxyglutarate bound to DNMT1 and stimulated its association with the RIP3 (show MPRIP Antibodies) promoter, inducing hypermethylation that reduces RIP3 (show MPRIP Antibodies) protein and consequently impaired RIP3 (show MPRIP Antibodies)-dependent necroptosis.
DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene.
DNA (cytosine-5)-methyltransferase 1
, CXXC-type zinc finger protein 9
, DNA MTase HsaI
, DNA methyltransferase HsaI
, DNA methyltransferase 1
, DNA (cytosine 5 ) methyltransferase 1
, DNA methyltransferase (cytosine 5 ) methyltransferase
, DNA methyltransferase b
, DNA MTase RnoIP
, DNA methyltransferase (cytosine-5) 1
, DNA methyltransferase I
, DNA MTase GgaI
, DNA MeTase
, DNA methyltransferase GgaI
, DNA MTase MmuI
, DNA methyltransferase MmuI