anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) Antibodies

DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Additionally we are shipping DNA (Cytosine-5)-Methyltransferase 1 Kits (31) and DNA (Cytosine-5)-Methyltransferase 1 Proteins (10) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DNMT1 1786 P26358
DNMT1 84350  
DNMT1 13433 P13864
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Top anti-DNA (Cytosine-5)-Methyltransferase 1 Antibodies at

Showing 10 out of 536 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated ChIP, CyTOF, FACS, ICC, IF, IHC, IHC (ff), IHC (fro), IHC (p), IP, SimWes, WB Western Blot: Dnmt1 Antibody (60B1220.1) [ABIN252481] - Western blot analysis for Dnmt1 using ABIN252481 at 2 ug/ml against 10 µg of cell lysates of mouse ES cell. Immunohistochemistry: Dnmt1 Antibody (60B1220.1) [ABIN252481] - IHC analysis of Dnmt1 using ABIN252481 at 2 ug/ml on formalin-fixed, paraffin-embedded medullar kidney tissue sections 0.1 mg Log in to see 7 to 9 Days
Human Rabbit Un-conjugated WB Western blot analysis of DNMT1 Antibody (S1105) (ABIN387879) in MDA-MB435 cell line lysates (35 µg/lane). DNMT1 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
Human Mouse Un-conjugated ChIP, IP, IHC, WB DNMT1 antibody (mAb) tested by Western blot. Detection of DNMT1 by Western blot. The analysis was performed using mouse ES whole-cell extract and DNMT1 antibody (mAb) at a 2 µg/ml dilution. 100 μg Log in to see 1 to 2 Days
Mouse Rabbit Un-conjugated WB Researcher: AnonymousApplication: Western BlottingSpecies+tissue/cell type: Lane 1:241 µg mouse mesenchymal stem cell lysate Primary Antibody dilution: 1:0000<br />Secondary Antibody: Anti-rabbit-HRP <br />Secondary Antibody Dilution: 1:00,000 WB Suggested Anti-Dnmt1 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  Mouse Lung 100 μL Log in to see 2 to 3 Days
Human Goat Un-conjugated ELISA, IHC, WB ABIN308397 (0.5µg/ml) staining of Jurkat cell lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
Human Rabbit Un-conjugated FACS, WB The anti-Dnmt1 C-term Pab (ABIN387878) is used in Western blot to detect Dnmt1 in Jurkat cell lysate. 400 μL Log in to see 10 to 11 Days
Human Rabbit Un-conjugated DB Dot blot analysis of anti-Dnmt1 Phospho-specific Pab (ABIN389901) on nitrocellulose membrane.  50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5 µg/mL. 400 μL Log in to see 10 to 11 Days
Fish Mouse Un-conjugated ChIP, IP, IHC, WB Dnmt1, 18ug H1299 lysate 1 in1000 Western Blotting. 100 μg Log in to see 2 to 3 Days
Fish Mouse Un-conjugated ChIP, IP, IHC, WB Dnmt1, 18ug H1299 lysate 1 in1000 Western Blotting. 100 μg Log in to see 2 to 3 Days
Human Mouse Un-conjugated ELISA, IHC, WB Black line: Control Antigen (100 ng);Purple line: Antigen(10ng);Blue line: Antigen (50 ng);Red line: Antigen (100 ng); Dilution: 1/10000 Figure 1: Western blot analysis using DNMT1 mAb against human DNMT1 recombinant protein. (Expected MW is 42.6 kDa) Dilution: 1/500 - 1/2000 100 μL Log in to see 8 to 11 Days

Top referenced anti-DNA (Cytosine-5)-Methyltransferase 1 Antibodies

  1. Human Monoclonal DNMT1 Primary Antibody for ChIP, CyTOF - ABIN252481 : Dennis, Fan, Geiman, Yan, Muegge: Lsh, a member of the SNF2 family, is required for genome-wide methylation. in Genes & development 2001 (PubMed)
    Show all 108 Pubmed References

  2. Human Monoclonal DNMT1 Primary Antibody for ChIP, IP - ABIN2668504 : Schnekenburger, Talaska, Puga: Chromium cross-links histone deacetylase 1-DNA methyltransferase 1 complexes to chromatin, inhibiting histone-remodeling marks critical for transcriptional activation. in Molecular and cellular biology 2007 (PubMed)
    Show all 4 Pubmed References

  3. Human Polyclonal DNMT1 Primary Antibody for WB - ABIN387879 : Peterson, Bögler, Taylor: p53-mediated repression of DNA methyltransferase 1 expression by specific DNA binding. in Cancer research 2003 (PubMed)
    Show all 9 Pubmed References

  4. Human Polyclonal DNMT1 Primary Antibody for DB, ELISA - ABIN4369817 : Saito, Kanai, Nakagawa, Sakamoto, Saito, Ishii, Hirohashi: Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas. in International journal of cancer. Journal international du cancer 2003 (PubMed)
    Show all 3 Pubmed References

  5. Human Polyclonal DNMT1 Primary Antibody for IHC (p), IHC - ABIN314281 : Nanduri, Makarenko, Reddy, Yuan, Pawar, Wang, Khan, Zhang, Kinsman, Peng, Kumar, Fox, Godley, Semenza, Prabhakar: Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis. in Proceedings of the National Academy of Sciences of the United States of America 2012 (PubMed)
    Show all 2 Pubmed References

  6. Human Polyclonal DNMT1 Primary Antibody for FACS, WB - ABIN387878 : Leu, Rahmatpanah, Shi, Wei, Liu, Yan, Huang: Double RNA interference of DNMT3b and DNMT1 enhances DNA demethylation and gene reactivation. in Cancer research 2003 (PubMed)
    Show all 7 Pubmed References

  7. Human Polyclonal DNMT1 Primary Antibody for EIA - ABIN358462 : Liao, Siu, Chan, Wong, Ngan, Chan, Li, Khoo, Cheung: Hypermethylation of RAS effector related genes and DNA methyltransferase 1 expression in endometrial carcinogenesis. in International journal of cancer. Journal international du cancer 2008 (PubMed)
    Show all 2 Pubmed References

  8. Human Polyclonal DNMT1 Primary Antibody for EIA - ABIN358447 : Yang, Andrade, Labialle, Moussette, Geneau, Sinnett, Belisle, Greenwood, Naumova: Parental effect of DNA (Cytosine-5) methyltransferase 1 on grandparental-origin-dependent transmission ratio distortion in mouse crosses and human families. in Genetics 2008 (PubMed)
    Show all 2 Pubmed References

  9. Human Polyclonal DNMT1 Primary Antibody for IF (p), IHC (p) - ABIN671796 : Khan, Tania, Wei, Mei, Fu, Cheng, Xu, Fu: Thymoquinone inhibits cancer metastasis by downregulating TWIST1 expression to reduce epithelial to mesenchymal transition. in Oncotarget 2015 (PubMed)

  10. Human Polyclonal DNMT1 Primary Antibody for IF (p), IHC (p) - ABIN757717 : Tan, Xu, Zeisberg, Zeisberg: High inorganic phosphate causes DNMT1 phosphorylation and subsequent fibrotic fibroblast activation. in Biochemical and biophysical research communications 2016 (PubMed)

More Antibodies against DNA (Cytosine-5)-Methyltransferase 1 Interaction Partners

Zebrafish DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) interaction partners

  1. Dnmt1 stability requires UHRF1 (show UHRF1 Antibodies) phosphorylation and that crosstalk between the proteins is essential for the function of these two important epigenetic regulators during gastrulation

  2. Lsh (show HELLS Antibodies) Is Essential for Maintaining Global DNA Methylation (show HELLS Antibodies) Levels in Amphibia and Fish and Interacts Directly with Dnmt1.

  3. Dnmt1 is required for hematopoietic stem and progenitor cells maintenance via cebpa (show CEBPA Antibodies) regulation during definitive hematopoiesis in zebrafish

  4. These data provide the first evidence that Uhrf1 (show UHRF1 Antibodies) and Dnmt1 function is required for vertebrate lens development and maintenance.

  5. These results suggest that Dnmt1 activity helps direct histone methylation by Suv39h1 (show SUV39H1 Antibodies) and that, together, Dnmt1 and Suv39h1 (show SUV39H1 Antibodies) help guide the terminal differentiation of particular tissues.

  6. Data show that in dnmt1 homozygous mutants, reactivation of gfp expression occurs in a reproducible subset of cells, raising the possibility of different sensitivities or alternative silencing mechanisms in discrete cell populations.

  7. Thus, our data suggest that Dnmt1 is dispensable for pancreatic duct or endocrine cell formation, but not for acinar cell survival. In addition, Dnmt1 may influence the differentiation of pancreatic beta cell progenitors.

Human DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) interaction partners

  1. Knockdown of DNMT1 could block the role of miR (show MLXIP Antibodies)-148a in promoting myocardial differentiation of human bone mesenchymal stromal cells.

  2. Data show that long noncoding RNA LUCAT1 activated DNA methyltransferase 1 (DNMT1), a major DNA methylation (show HELLS Antibodies) protein, to repress the expression of tumor-suppressor genes, leading to the development and progression of esophageal squamous cell carcinoma (ESCC).

  3. Genetic variation in DNMT1 gene is not associated with gastric cancer.

  4. Study investigated the counteraction of oxidative stress by vitamin E in the colorectal cancer cell line Caco-2 under normal and high glucose cell culture condition. Gene expression and promoter methylation of the DNA repair gene MutL homolog 1 (MLH1 (show MLH1 Antibodies)) and the DNA methyltransferase 1 (DNMT1) were investigated. Induction of MLH1 (show MLH1 Antibodies) and DNMT1 gene expression was noticed, accompanied by an increase in global methylation.

  5. The finding that zebularine upregulates CYP (show PPIG Antibodies) gene expression through DNMT1 and PKR (show PKLR Antibodies) modulation sheds light on the mechanisms controlling hepatocyte function and thus may aid in the development of new in-vitro systems using high-functioning hepatocytes

  6. Results show that upon DNMT1 depletion, overall pattern of sites show significant differential methylation.

  7. DNMT1 contributes to promoter hypermethylation and epigenetic NHERF1 (show SLC9A3R1 Antibodies) silencing in colon cancer.

  8. the expression of WIF-1 (show WIF1 Antibodies) was low in GBC cells due to aberrant hypermethylation of its promoter region. Additionally, an alternative pathogenesis of GBC was indicated in which c-Jun (show JUN Antibodies) causes hypermethylation of the WIF-1 (show WIF1 Antibodies) promoter region, and represses the expression of WIF-1 (show WIF1 Antibodies) through transcriptional regulation and interaction with DNMT1 as an early event in the tumorigenesis of GBC.

  9. DNMT1 was downregulated in the Lung Cancer group and its expression was further reduced in the presence of increasing malignant burden as indicated by the endobronchial findings further suggesting an Lung Cancer-specific signature.

  10. SAC (show ADCY10 Antibodies) decreased the levels of 5-methylcytosine, DNMT activity, messenger RNA (mRNA) and protein levels of DNMT1. Additionally, SAC (show ADCY10 Antibodies) treatment resulted in re-expression of the mRNA and proteins of silenced tumor suppressor gene CDKN1A accompany with reduced cell division control 2 (show CDK1 Antibodies) expression.

Pig (Porcine) DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) interaction partners

  1. Dnmt1 was indispensable for oocyte cytoplasmic maturation, providing a novel role for Dnmt1 in the regulation of oocyte maturation.

  2. Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1, Dnmt3a (show DNMT3A Antibodies), Hdac1 (show HDAC1 Antibodies), Kdm3a (show KDM3A Antibodies) and Uhrf1 (show UHRF1 Antibodies) were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).

  3. DNMT1o is localized mainly in the nuclei of oocytes and early embryos, whereas DNMT1s is expressed in the ooplasm (show NLRP5 Antibodies) cortex of oocytes and cytoplasm of early embryos.

  4. results indicate that loss of Dnmt1 in the maternal nucleus during SCNT significantly contributes to the unfaithful maintenance of methylation imprints in cloned embryos

  5. Oocyte-specific Dnmt1 is cytoplasmic during early development.

  6. Dnmt1 mRNA abundance plays an important role during protein regulation, Dnmt1 enzyme is mainly posttranscriptionally regulated.

Cow (Bovine) DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) interaction partners

  1. DNMT1 silencing significantly decreased the methylation levels of miR (show MYLIP Antibodies)-29b promoter, up-regulated miR (show MYLIP Antibodies)-29b expression and inhibited bovine viral diarrhea virus replication.

  2. Through down-regulating the expression of DNMT1, miR (show MYLIP Antibodies)-152 reduced Global DNA methylation (show HELLS Antibodies) and the activity of DNMT to reactivate the lactation signal transduction genes Akt (show AKT1 Antibodies) and Ppar gamma (show PPARG Antibodies).

  3. More DNMT1 mRNA was detected in the transgenic somatic cell nuclear transfer (SCNT) group than the other three groups. Hsp 70.1 mRNA was detected in the in vitro fertilzation embryos. Mash2 (show ASCL2 Antibodies) mRNA was present at highest levels in transgenic SCNT embryos.

  4. Our results indicate an essential role for Dnmt1 during bovine preimplantation development (show MTA2 Antibodies), and suggest proper transcriptional reprogramming of this gene family in SCNT embryos.

  5. Abnormal gene expression of DNMT, INFT, and MHC1 was noted in the majority of cloned embryos, indicating inefficient nuclear reprogramming and retarded embryo development.

  6. Results describe the alternative splicing and expression analysis of bovine DNA methyltransferase 1.

  7. Report inhibition of DNA methyltransferase 1 expression in bovine fibroblast cells used for nuclear transfer.

Arabidopsis thaliana DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) interaction partners

  1. The findings reveal that MET1-mediated shoot regeneration is regulated by the cytokinin-induced cell cycle, and provide new insights into the regulation of DNA methylation (show HELLS Antibodies) in shoot regeneration.

  2. Long-term stability and epigenetic features differ for individual loci. Our data show that over-expression of MET1, and potentially of other genes encoding epigenetic factors, offers an alternative strategy to identify epigenetic target genes and to create novel epi (show TFPI Antibodies)-alleles

  3. MET1 confines ARID1 to the vegetative cell of male gametes, but ARID1 conversely represses MET1 in the central cell of female gametes.

  4. MET1 is a thylakoid-associated TPR protein involved in photosystem II supercomplex formation and repair in Arabidopsis

  5. Met1 gene expression throughout normal development, particularly in the flower

  6. MET1 is a contributor to epigenetic diversity in Arabidopsis.

  7. VIM (show VIM Antibodies) proteins regulate genome-wide epigenetic gene silencing through coordinated modulation of DNA methylation (show HELLS Antibodies) and histone modification status in collaboration with MET1

  8. VIM (show VIM Antibodies) proteins function in transcriptional regulation via their roles in the MET1 DNA methylation (show HELLS Antibodies) pathway.

  9. Genetic studies indicate that the Polycomb (show CBX2 Antibodies) Repressive Complex 2 (PRC2) but not the DNA METHYLTRANSFERASE1 (MET1) is involved in regulating imprinted expression in the embryo. [MET1]

  10. MET1 restores body methylation, which is region-specific but random with respect to the affected CG sites, and is moderately although not decisively influenced by transcription.

Mouse (Murine) DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) interaction partners

  1. knockdown of DNMT1 in cerebellar granule neurons caused upregulation of some, but not all subtypes of MHC-I genes.

  2. Findings indicate that the steady-state level of DNMT1 protein in cycling cell populations is controlled at the level of transcription and that the interaction of DNMT1 and USP7 (show USP7 Antibodies) is unlikely to play a major role in DNMT1 homeostasis.

  3. Increased shear stress without a change in flow direction initiates arteriogenic growth; however, it also elicits DNMT1-dependent endothelial cells DNA hypermethylation. In turn, this diminishes mechanosensing, augments shear stress set point, and constrains the ultimate arteriogenic capacity of the vessel.

  4. Single-cell transcriptome analysis detected Dnmt1 expression in murine migratory GABAergic embryonic preoptic area (POA)-derived cells. Deletion of Dnmt1 in postmitotic immature cells of the POA caused defective migration and severely diminished adult cortical interneuron numbers. DNMT1 preserves the migratory shape in part through negative regulation of Pak6 (show PAK6 Antibodies), which stimulates neuritogenesis postmigration.

  5. The aim of the present study is to investigate spatial and temporal expression levels and subcellular localizations of the DNMT1, DNMT3A (show DNMT3A Antibodies), and DNMT3B (show DNMT3B Antibodies) proteins in the mouse germinal vesicle (GV) and metaphase II (MII) oocytes, and early embryos from 1-cell to blastocyst stages.

  6. DNMT1 ablation from kidney proximal tubules enhanced cisplatin-induced acute kidney injury in mice, suggesting a renoprotective role of DNA methylation (show HELLS Antibodies).

  7. Epigenetic enhancement of the post-replicative DNA mismatch repair of mammalian genomes by a Hemi-(m)CpG-Np95 (show UHRF1 Antibodies)-Dnmt1 axis has been demonstrated for humans and mice.

  8. We show that expression of Id-1 (show IDH1 Antibodies), a negative regulator of myogenesis, is enhanced in Dnmt1-deficient cultures, leading to enhanced transdifferentiation of myoblasts toward the osteogenic lineage. Thus, these studies demonstrate that Dnmt1 influences cellular identity and determines lineage fidelity.

  9. this study shows that DNMT1 might directly repress p53 (show TP53 Antibodies), at least in part, by binding to the p53 (show TP53 Antibodies) promoter locus

  10. Knockdown of DNMT3A (show DNMT3A Antibodies) or DNMT1 protected neurons against mutant Htt (show HTT Antibodies)-induced toxicity, together demonstrating a requirement for DNMTs in mutant Htt (show HTT Antibodies)-triggered neuronal death and suggesting a neurodegenerative mechanism based on DNA methylation (show HELLS Antibodies)-mediated transcriptional repression.

DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) Antigen Profile

Protein Summary

DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with DNMT1

  • DNA methyltransferase 1 (DNMT1) antibody
  • DNA (cytosine-5-)-methyltransferase 1 (dnmt1) antibody
  • DNA methyltransferase 1 (Dnmt1) antibody
  • methyltransferase 1 (MET1) antibody
  • DNA methyltransferase (cytosine-5) 1 (Dnmt1) antibody
  • ADCADN antibody
  • AIM antibody
  • cb983 antibody
  • cb1075 antibody
  • Cxxc9 antibody
  • DDM2 antibody
  • dmnt1 antibody
  • DMT01 antibody
  • DMT1 antibody
  • Dnmt antibody
  • Dnmt1o antibody
  • fb05h01 antibody
  • HSN1E antibody
  • m.MmuI antibody
  • MCMT antibody
  • Met-1 antibody
  • Met1 antibody
  • MET2 antibody
  • methyltransferase 1 antibody
  • METI antibody
  • MommeD2 antibody
  • mta antibody
  • MTase antibody
  • wu:fb05h01 antibody

Protein level used designations for DNMT1

DNA (cytosine-5)-methyltransferase 1 , ddn , CXXC-type zinc finger protein 9 , DNA MTase HsaI , DNA methyltransferase HsaI , m.HsaI , DNA methyltransferase 1 , DNA (cytosine 5 ) methyltransferase 1 , DNA methyltransferase (cytosine 5 ) methyltransferase , DNA methyltransferase b , DNA MTase RnoIP , DNA methyltransferase (cytosine-5) 1 , DNA methyltransferase I , MCMT , m.RnoIP , DNA MTase GgaI , DNA MeTase , DNA methyltransferase GgaI , m.GgaI , DNA MTase MmuI , DNA methyltransferase MmuI

443549 Ovis aries
30430 Danio rerio
1786 Homo sapiens
476715 Canis lupus familiaris
606746 Sus scrofa
281119 Bos taurus
84350 Rattus norvegicus
396011 Gallus gallus
834975 Arabidopsis thaliana
13433 Mus musculus
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