anti-DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) Antibodies

DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Additionally we are shipping DNA (Cytosine-5)-Methyltransferase 1 Kits (28) and DNA (Cytosine-5)-Methyltransferase 1 Proteins (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DNMT1 1786 P26358
DNMT1 84350  
DNMT1 13433 P13864
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Top anti-DNA (Cytosine-5)-Methyltransferase 1 Antibodies at antibodies-online.com

Showing 10 out of 488 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated ChIP, CyTOF, FACS, ICC, IF, IHC, IHC (ff), IHC (fro), IHC (p), IP, SimWes, WB Western Blot: Dnmt1 Antibody (60B1220.1) [ABIN252481] - Western blot analysis for Dnmt1 using ABIN252481 at 2 ug/ml against 10 µg of cell lysates of mouse ES cell. Immunohistochemistry: Dnmt1 Antibody (60B1220.1) [ABIN252481] - IHC analysis of Dnmt1 using ABIN252481 at 2 ug/ml on formalin-fixed, paraffin-embedded medullar kidney tissue sections 0.1 mg Log in to see 7 to 9 Days
$514.63
Details
Human Mouse Un-conjugated ChIP, IP, IHC, WB DNMT1 antibody (mAb) tested by Western blot. Detection of DNMT1 by Western blot. The analysis was performed using mouse ES whole-cell extract and DNMT1 antibody (mAb) at a 2 µg/ml dilution. 100 μg Log in to see 1 to 2 Days
$495.83
Details
Mouse Rabbit Un-conjugated WB Researcher: AnonymousApplication: Western BlottingSpecies+tissue/cell type: Lane 1:241 µg mouse mesenchymal stem cell lysate Primary Antibody dilution: 1:0000<br />Secondary Antibody: Anti-rabbit-HRP <br />Secondary Antibody Dilution: 1:00,000 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of DNMT1 Antibody (S1105) (ABIN387879) in MDA-MB435 cell line lysates (35 µg/lane). DNMT1 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated FACS, WB The anti-Dnmt1 C-term Pab (ABIN387878) is used in Western blot to detect Dnmt1 in Jurkat cell lysate. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated DB Dot blot analysis of anti-Dnmt1 Phospho-specific Pab (ABIN389901) on nitrocellulose membrane.  50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5 µg/mL. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Fish Mouse Un-conjugated ChIP, IP, IHC, WB Dnmt1, 18ug H1299 lysate 1 in1000 Western Blotting. 100 μg Log in to see 2 to 3 Days
$383.90
Details
Fish Mouse Un-conjugated ChIP, IP, IHC, WB Dnmt1, 18ug H1299 lysate 1 in1000 Western Blotting. 100 μg Log in to see 2 to 3 Days
$383.90
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IF (p), IHC (p) Formalin-fixed and paraffin embedded mouse lymphoma tissue labeled with Anti-Dnmt1 Polyclonal Antibody, Unconjugated (ABIN671796) at 1:200, followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-Dnmt1 Polyclonal Antibody, Unconjugated (ABIN671796) at 1:200, followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$318.45
Details

DNMT1 Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-DNA (Cytosine-5)-Methyltransferase 1 Antibodies

  1. Human Monoclonal DNMT1 Primary Antibody for ChIP, CyTOF - ABIN252481 : Dennis, Fan, Geiman, Yan, Muegge: Lsh, a member of the SNF2 family, is required for genome-wide methylation. in Genes & development 2001 (PubMed)
    Show all 106 Pubmed References

  2. Human Monoclonal DNMT1 Primary Antibody for IF, WB - ABIN968896 : Robertson, Ait-Si-Ali, Yokochi, Wade, Jones, Wolffe: DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters. in Nature genetics 2000 (PubMed)
    Show all 4 Pubmed References

  3. Human Monoclonal DNMT1 Primary Antibody for ChIP, IP - ABIN2668504 : Schnekenburger, Talaska, Puga: Chromium cross-links histone deacetylase 1-DNA methyltransferase 1 complexes to chromatin, inhibiting histone-remodeling marks critical for transcriptional activation. in Molecular and cellular biology 2007 (PubMed)
    Show all 4 Pubmed References

  4. Human Monoclonal DNMT1 Primary Antibody for IF, WB - ABIN968895 : Robertson, Uzvolgyi, Liang, Talmadge, Sumegi, Gonzales, Jones: The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. in Nucleic acids research 1999 (PubMed)
    Show all 4 Pubmed References

  5. Human Polyclonal DNMT1 Primary Antibody for DB, ELISA - ABIN4369817 : Saito, Kanai, Nakagawa, Sakamoto, Saito, Ishii, Hirohashi: Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas. in International journal of cancer. Journal international du cancer 2003 (PubMed)
    Show all 3 Pubmed References

  6. Human Polyclonal DNMT1 Primary Antibody for IHC (p), IHC - ABIN314281 : Nanduri, Makarenko, Reddy, Yuan, Pawar, Wang, Khan, Zhang, Kinsman, Peng, Kumar, Fox, Godley, Semenza, Prabhakar: Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis. in Proceedings of the National Academy of Sciences of the United States of America 2012 (PubMed)
    Show all 2 Pubmed References

  7. Human Polyclonal DNMT1 Primary Antibody for FACS, WB - ABIN387878 : Peterson, Bögler, Taylor: p53-mediated repression of DNA methyltransferase 1 expression by specific DNA binding. in Cancer research 2003 (PubMed)
    Show all 7 Pubmed References

  8. Human Polyclonal DNMT1 Primary Antibody for WB - ABIN387879 : Leu, Rahmatpanah, Shi, Wei, Liu, Yan, Huang: Double RNA interference of DNMT3b and DNMT1 enhances DNA demethylation and gene reactivation. in Cancer research 2003 (PubMed)
    Show all 7 Pubmed References

  9. Human Polyclonal DNMT1 Primary Antibody for IF (p), IHC (p) - ABIN671796 : Khan, Tania, Wei, Mei, Fu, Cheng, Xu, Fu: Thymoquinone inhibits cancer metastasis by downregulating TWIST1 expression to reduce epithelial to mesenchymal transition. in Oncotarget 2015 (PubMed)

  10. Human Polyclonal DNMT1 Primary Antibody for WB - ABIN151855 : Min, Kim, Choi, Liang, Ko, Rhee, Bang, Ham, Park, Lee: Selective death of cancer cells by preferential induction of reactive oxygen species in response to (-)-epigallocatechin-3-gallate. in Biochemical and biophysical research communications 2012 (PubMed)

More Antibodies against DNA (Cytosine-5)-Methyltransferase 1 Interaction Partners

Zebrafish DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) interaction partners

  1. Dnmt1 stability requires UHRF1 (show UHRF1 Antibodies) phosphorylation and that crosstalk between the proteins is essential for the function of these two important epigenetic regulators during gastrulation

  2. Lsh (show HELLS Antibodies) Is Essential for Maintaining Global DNA Methylation (show HELLS Antibodies) Levels in Amphibia and Fish and Interacts Directly with Dnmt1.

  3. Dnmt1 is required for hematopoietic stem and progenitor cells maintenance via cebpa (show CEBPA Antibodies) regulation during definitive hematopoiesis in zebrafish

  4. These data provide the first evidence that Uhrf1 (show UHRF1 Antibodies) and Dnmt1 function is required for vertebrate lens development and maintenance.

  5. These results suggest that Dnmt1 activity helps direct histone methylation by Suv39h1 (show SUV39H1 Antibodies) and that, together, Dnmt1 and Suv39h1 (show SUV39H1 Antibodies) help guide the terminal differentiation of particular tissues.

  6. Data show that in dnmt1 homozygous mutants, reactivation of gfp expression occurs in a reproducible subset of cells, raising the possibility of different sensitivities or alternative silencing mechanisms in discrete cell populations.

  7. Thus, our data suggest that Dnmt1 is dispensable for pancreatic duct or endocrine cell formation, but not for acinar cell survival. In addition, Dnmt1 may influence the differentiation of pancreatic beta cell progenitors.

Human DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) interaction partners

  1. PRIMA-1 could cause the demethylation of TP73 (show TP73 Antibodies), through DNMT1 depletion, to subsequently enhance the unfolded protein response

  2. Results show that DNMT1 is highly expressed in lung tumors compared to normal tissues, and that DBCCR1 attenuates its expression suggesting a reciprocal regulation between genetic silencing of cancer suppressor genes and activating DNA methylation (show HELLS Antibodies).

  3. A decreased expression of anti-DNMT1 miRNAs might account for azacitidine resistance in higher-risk myelodysplastic syndrome and acute myeloid leukemia (show BCL11A Antibodies) , and measuring miRNA expression before and during treatment might help predict primary or secondary azacitidine resistance

  4. these findings revealed that miR (show MLXIP Antibodies)-217 promotes fibroblasts senescence by suppressing DNMT1-mediated methylation of p16 and pRb (show RB1 Antibodies) by targeting the DNMT1 3'-UTR (show UTS2R Antibodies).

  5. Ultraviolet B rays suppressed SIRT1 (show SIRT1 Antibodies) expression by activating AhR (show AHR Antibodies), and subsequently inhibited DNMT1 activity in CD4 (show CD4 Antibodies)+ T cells from systemic lupus erythematosus patients.

  6. DNMT1 expression is increased in low-grade gliomas and is associated with improved survival. Its expression is regulated by phosphorylated c-Jun (show JUN Antibodies) and correlates with high DNA methylation (show HELLS Antibodies).

  7. in patents with chronic hepatitis B, data showed a DNMT1 overexpression significantly correlated to nucleo(t)side analogs (NA) therapy duration and higher regional mitochondrial DNA hypermethylation; this might suggest an epigenetic alteration that could be involved in one of the possible mechanisms of mitochondrial gene regulation during NAs (show SCN9A Antibodies) therapy

  8. The meta-analysis also suggested that DNMT1 rs16999593 (T/C) may be associated with gastric cancer, while rs2228611 (G/A) may be associated with breast cancer. In future research, large-scale and well-designed studies are required to verify these findings.

  9. FQI1 mediates alteration of the tumor epigenome by DNMT1-LSF (show TFCP2 Antibodies) complex disruption, leading to aberrant DNA methylation (show HELLS Antibodies) and gene expression.

  10. DNMT1-mediated transcriptional upregulation of IGF2 is a novel mechanism of resistance to HDIs, highlighting the role of epigenetic deregulation of IGF2 in HDI resistance and the potential value of the H19 (show NCKAP1 Antibodies)/IGF2 ICR hypermethylation and DNMT1 expression as predictive biomarkers in HDI-based anticancer therapies.

Pig (Porcine) DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) interaction partners

  1. Dnmt1 was indispensable for oocyte cytoplasmic maturation, providing a novel role for Dnmt1 in the regulation of oocyte maturation.

  2. Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1, Dnmt3a (show DNMT3A Antibodies), Hdac1 (show HDAC1 Antibodies), Kdm3a (show KDM3A Antibodies) and Uhrf1 (show UHRF1 Antibodies) were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).

  3. DNMT1o is localized mainly in the nuclei of oocytes and early embryos, whereas DNMT1s is expressed in the ooplasm (show NLRP5 Antibodies) cortex of oocytes and cytoplasm of early embryos.

  4. results indicate that loss of Dnmt1 in the maternal nucleus during SCNT significantly contributes to the unfaithful maintenance of methylation imprints in cloned embryos

  5. Oocyte-specific Dnmt1 is cytoplasmic during early development.

  6. Dnmt1 mRNA abundance plays an important role during protein regulation, Dnmt1 enzyme is mainly posttranscriptionally regulated.

Cow (Bovine) DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) interaction partners

  1. DNMT1 silencing significantly decreased the methylation levels of miR (show MYLIP Antibodies)-29b promoter, up-regulated miR (show MYLIP Antibodies)-29b expression and inhibited bovine viral diarrhea virus replication.

  2. Through down-regulating the expression of DNMT1, miR (show MYLIP Antibodies)-152 reduced Global DNA methylation (show HELLS Antibodies) and the activity of DNMT to reactivate the lactation signal transduction genes Akt (show AKT1 Antibodies) and Ppar gamma (show PPARG Antibodies).

  3. More DNMT1 mRNA was detected in the transgenic somatic cell nuclear transfer (SCNT) group than the other three groups. Hsp 70.1 mRNA was detected in the in vitro fertilzation embryos. Mash2 (show ASCL2 Antibodies) mRNA was present at highest levels in transgenic SCNT embryos.

  4. Our results indicate an essential role for Dnmt1 during bovine preimplantation development (show MTA2 Antibodies), and suggest proper transcriptional reprogramming of this gene family in SCNT embryos.

  5. Dnmt1 is retained in the cytoplasm in metaphase II stage oocytes and zygotes, it enters the nuclei of 8-16 cell stage embryos

  6. Abnormal gene expression of DNMT, INFT, and MHC1 was noted in the majority of cloned embryos, indicating inefficient nuclear reprogramming and retarded embryo development.

  7. Results describe the alternative splicing and expression analysis of bovine DNA methyltransferase 1.

  8. Report inhibition of DNA methyltransferase 1 expression in bovine fibroblast cells used for nuclear transfer.

Arabidopsis thaliana DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) interaction partners

  1. Long-term stability and epigenetic features differ for individual loci. Our data show that over-expression of MET1, and potentially of other genes encoding epigenetic factors, offers an alternative strategy to identify epigenetic target genes and to create novel epi (show TFPI Antibodies)-alleles

  2. MET1 confines ARID1 to the vegetative cell of male gametes, but ARID1 conversely represses MET1 in the central cell of female gametes.

  3. MET1 is a thylakoid-associated TPR protein involved in photosystem II supercomplex formation and repair in Arabidopsis

  4. Met1 gene expression throughout normal development, particularly in the flower

  5. MET1 is a contributor to epigenetic diversity in Arabidopsis.

  6. VIM (show VIM Antibodies) proteins regulate genome-wide epigenetic gene silencing through coordinated modulation of DNA methylation (show HELLS Antibodies) and histone modification status in collaboration with MET1

  7. VIM (show VIM Antibodies) proteins function in transcriptional regulation via their roles in the MET1 DNA methylation (show HELLS Antibodies) pathway.

  8. Genetic studies indicate that the Polycomb (show CBX2 Antibodies) Repressive Complex 2 (PRC2) but not the DNA METHYLTRANSFERASE1 (MET1) is involved in regulating imprinted expression in the embryo. [MET1]

  9. MET1 restores body methylation, which is region-specific but random with respect to the affected CG sites, and is moderately although not decisively influenced by transcription.

  10. There is a mechanistic link between two major epigenetic pathways involved in histone and DNA methylation (show HELLS Antibodies) in plants by physical interaction of MET1 with the FIS-PRC2 core component MEA.

Mouse (Murine) DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) interaction partners

  1. Sp1 (show SP1 Antibodies)/NFkappaB p65 (show NFkBP65 Antibodies)-Dnmt1 pathway may be exploited as a therapeutic target for protecting against podocyte injury in diabetic nephropathy.

  2. 2-hydroxyglutarate bound to DNMT1 and stimulated its association with the RIP3 (show MPRIP Antibodies) promoter, inducing hypermethylation that reduces RIP3 (show MPRIP Antibodies) protein and consequently impaired RIP3 (show MPRIP Antibodies)-dependent necroptosis.

  3. The results demonstrated that Islet1 (show ISL1 Antibodies) upregulated expression of general control of amino acid biosynthesis protein 5 (show CAPS Antibodies) (Gcn5 (show KAT2A Antibodies)) and enhanced the binding of Gcn5 (show KAT2A Antibodies) to the promoters of GATA binding protein 4 (GATA4 (show GATA4 Antibodies)) and NK2 homeobox 5 (Nkx2.5 (show NKX2-5 Antibodies)). In addition, Islet-1 (show ISL1 Antibodies) downregulated DNA methyltransferase (DNMT)1 expression and reduced its binding to the GATA4 (show GATA4 Antibodies) promoter.

  4. Data show that RGS6 (show RGS6 Antibodies) loss impairs p53 (show TP53 Antibodies) activation and promotes aberrant accumulation of oncogenic protein DNMT1 in urothelium.

  5. Data (including data from studies using knockout/transgenic mice) suggest that neuronal Dnmt1 regulates energy homeostasis through pathways controlling energy homeostasis; here, neuronal Dnmt1 deficiency prevents diet-induced obesity, reduces adiposity, reduces food intake, and increases energy expenditure in male mice.

  6. Deletion of DNmt1 in postnatal forebrain neurons results in anxiolytic and antidepressant-like responses.

  7. Upon lysolecithin injection in the spinal cord of transgenic mice, study detected defective oligodendrocyte progenitor cells differentiation and inefficient remyelination in the DNA methyltransferase 3a (show DNMT3A Antibodies) null and DNA methyltransferase 1/DNA methyltransferase 3a (show DNMT3A Antibodies) null mice.

  8. Data from studies using mouse embryonic fibroblasts suggest that cell proliferation rate positively correlates with expression of Dnmt1 in G1 phase; global DNA methylation (show HELLS Antibodies) is significantly higher in G1 phase than in G2/M phase; larger methylation differences are observed on promoters of pluripotency-related genes; thus, high cell proliferation rates promote generation of induced pluripotent stem cells.

  9. Dnmt1 and Ezh2 (show EZH2 Antibodies) play distinct roles in the different islet cell types

  10. we extended this work by using a biotinylation tagging approach to characterize DNMT1 protein complexes in mouse erythroleukemic cells. We identified novel DNMT1 interactions with several hematopoietic transcription factors with essential roles in erythroid differentiation

DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) Antigen Profile

Protein Summary

DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with DNMT1

  • DNA methyltransferase 1 (DNMT1) antibody
  • DNA (cytosine-5-)-methyltransferase 1 (dnmt1) antibody
  • DNA methyltransferase 1 (Dnmt1) antibody
  • methyltransferase 1 (MET1) antibody
  • DNA methyltransferase (cytosine-5) 1 (Dnmt1) antibody
  • ADCADN antibody
  • AIM antibody
  • cb983 antibody
  • cb1075 antibody
  • Cxxc9 antibody
  • DDM2 antibody
  • DECREASED DNA METHYLATION 2 antibody
  • dmnt1 antibody
  • DMT01 antibody
  • DMT1 antibody
  • DNA METHYLTRANSFERASE antibody
  • DNA METHYLTRANSFERASE 01 antibody
  • DNA METHYLTRANSFERASE 1 antibody
  • Dnmt antibody
  • Dnmt1o antibody
  • fb05h01 antibody
  • HSN1E antibody
  • m.MmuI antibody
  • MCMT antibody
  • Met-1 antibody
  • Met1 antibody
  • MET2 antibody
  • methyltransferase 1 antibody
  • METHYLTRANSFERASE 2 antibody
  • METHYLTRANSFERASE I antibody
  • METI antibody
  • MommeD2 antibody
  • mta antibody
  • MTase antibody
  • wu:fb05h01 antibody

Protein level used designations for DNMT1

DNA (cytosine-5)-methyltransferase 1 , ddn , CXXC-type zinc finger protein 9 , DNA MTase HsaI , DNA methyltransferase HsaI , m.HsaI , DNA methyltransferase 1 , DNA (cytosine 5 ) methyltransferase 1 , DNA methyltransferase (cytosine 5 ) methyltransferase , DNA methyltransferase b , DNA MTase RnoIP , DNA methyltransferase (cytosine-5) 1 , DNA methyltransferase I , MCMT , m.RnoIP , DNA MTase GgaI , DNA MeTase , DNA methyltransferase GgaI , m.GgaI , DNA MTase MmuI , DNA methyltransferase MmuI

GENE ID SPECIES
443549 Ovis aries
30430 Danio rerio
1786 Homo sapiens
476715 Canis lupus familiaris
606746 Sus scrofa
281119 Bos taurus
84350 Rattus norvegicus
396011 Gallus gallus
834975 Arabidopsis thaliana
13433 Mus musculus
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