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DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Additionally we are shipping DNA (Cytosine-5)-Methyltransferase 1 Antibodies (479) and DNA (Cytosine-5)-Methyltransferase 1 Proteins (8) and many more products for this protein.
Showing 7 out of 28 products:
Qin, Leonhardt, Pichler: Regulation of DNA methyltransferase 1 by interactions and modifications. in Nucleus (Austin, Tex.) 2011
Dnmt1 stability requires UHRF1 phosphorylation and that crosstalk between the proteins is essential for the function of these two important epigenetic regulators during gastrulation
Lsh Is Essential for Maintaining Global DNA Methylation Levels in Amphibia and Fish and Interacts Directly with Dnmt1.
Dnmt1 is required for hematopoietic stem and progenitor cells maintenance via cebpa (show CEBPA ELISA Kits) regulation during definitive hematopoiesis in zebrafish
These data provide the first evidence that Uhrf1 and Dnmt1 function is required for vertebrate lens development and maintenance.
These results suggest that Dnmt1 activity helps direct histone methylation by Suv39h1 and that, together, Dnmt1 and Suv39h1 help guide the terminal differentiation of particular tissues.
Data show that in dnmt1 homozygous mutants, reactivation of gfp expression occurs in a reproducible subset of cells, raising the possibility of different sensitivities or alternative silencing mechanisms in discrete cell populations.
Thus, our data suggest that Dnmt1 is dispensable for pancreatic duct or endocrine cell formation, but not for acinar cell survival. In addition, Dnmt1 may influence the differentiation of pancreatic beta cell progenitors.
This is the first demonstration that dysregulated KLF4 (show KLF4 ELISA Kits) expression associates with poor differentiation of pancreatic cancer. Epigenetic activation of miR (show MLXIP ELISA Kits)-152/DNMT1/KLF4 (show KLF4 ELISA Kits) signaling pathway by dietary DIM causes differentiation and significant growth inhibition of pancreatic cancer cells, highlighting its translational implications for pancreatic and other cancers.
Investigations demonstrate that KLF5 (show KLF5 ELISA Kits) genomic loci are hypermethylated at proximal exon 4 and suppression of DNA methyltransferase 1 (DNMT1) expression by ShRNAs or a methylation inhibitor 5-Aza-CdR (show RUNX1T1 ELISA Kits) can recover KLF5 (show KLF5 ELISA Kits) expression.
(i) ectopic expression of miR (show MLXIP ELISA Kits)-148a induces programmed cell death and represses cell proliferation by targeting DNMT1; (ii) miR (show MLXIP ELISA Kits)-148a gene is regulated by DNA methylation and DNMT1 in prostate cancer. We conclude that miR (show MLXIP ELISA Kits)-148a is silenced by DNA methylation and ectopic expression of miR (show MLXIP ELISA Kits)-148a suppresses DNMT1 expression and induced apoptotic genes expression in hormone-refractory prostate cancer cells.
Results show that DNMT1 function is regulated by LSD1 which mediates its recruitment at the transcriptional start site of its target genes to modulates there epigenetic status by altering H3K4me2 and H3K9Ac and DNA methylation.
elevated DNMT1 was correlated with decreased PPAR-gamma (show PPARG ELISA Kits), and increased proinflammatory cytokine production in the peripheral blood monocytes isolated from the patients with atherosclerosis, compared to those of healthy donors.
Results indicated that miR (show MLXIP ELISA Kits)-152-3p can inhibit glioma cell proliferation and invasion activities by decreasing DNMT1.
PRIMA-1 could cause the demethylation of TP73 (show TP73 ELISA Kits), through DNMT1 depletion, to subsequently enhance the unfolded protein response
Results show that DNMT1 is highly expressed in lung tumors compared to normal tissues, and that DBCCR1 attenuates its expression suggesting a reciprocal regulation between genetic silencing of cancer suppressor genes and activating DNA methylation.
A decreased expression of anti-DNMT1 miRNAs might account for azacitidine resistance in higher-risk myelodysplastic syndrome and acute myeloid leukemia (show BCL11A ELISA Kits) , and measuring miRNA expression before and during treatment might help predict primary or secondary azacitidine resistance
these findings revealed that miR (show MLXIP ELISA Kits)-217 promotes fibroblasts senescence by suppressing DNMT1-mediated methylation of p16 and pRb (show RB1 ELISA Kits) by targeting the DNMT1 3'-UTR (show UTS2R ELISA Kits).
Dnmt1 was indispensable for oocyte cytoplasmic maturation, providing a novel role for Dnmt1 in the regulation of oocyte maturation.
Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1, Dnmt3a, Hdac1, Kdm3a and Uhrf1 were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).
DNMT1o is localized mainly in the nuclei of oocytes and early embryos, whereas DNMT1s is expressed in the ooplasm cortex of oocytes and cytoplasm of early embryos.
results indicate that loss of Dnmt1 in the maternal nucleus during SCNT significantly contributes to the unfaithful maintenance of methylation imprints in cloned embryos
Oocyte-specific Dnmt1 is cytoplasmic during early development.
Dnmt1 mRNA abundance plays an important role during protein regulation, Dnmt1 enzyme is mainly posttranscriptionally regulated.
DNMT1 silencing significantly decreased the methylation levels of miR (show MYLIP ELISA Kits)-29b promoter, up-regulated miR (show MYLIP ELISA Kits)-29b expression and inhibited bovine viral diarrhea virus replication.
Through down-regulating the expression of DNMT1, miR (show MYLIP ELISA Kits)-152 reduced Global DNA methylation and the activity of DNMT to reactivate the lactation signal transduction genes Akt (show AKT1 ELISA Kits) and Ppar gamma (show PPARG ELISA Kits).
More DNMT1 mRNA was detected in the transgenic somatic cell nuclear transfer (SCNT) group than the other three groups. Hsp 70.1 mRNA was detected in the in vitro fertilzation embryos. Mash2 (show ASCL2 ELISA Kits) mRNA was present at highest levels in transgenic SCNT embryos.
Our results indicate an essential role for Dnmt1 during bovine preimplantation development (show MTA2 ELISA Kits), and suggest proper transcriptional reprogramming of this gene family in SCNT embryos.
Dnmt1 is retained in the cytoplasm in metaphase II stage oocytes and zygotes, it enters the nuclei of 8-16 cell stage embryos
Abnormal gene expression of DNMT, INFT, and MHC1 was noted in the majority of cloned embryos, indicating inefficient nuclear reprogramming and retarded embryo development.
Results describe the alternative splicing and expression analysis of bovine DNA methyltransferase 1.
Report inhibition of DNA methyltransferase 1 expression in bovine fibroblast cells used for nuclear transfer.
Long-term stability and epigenetic features differ for individual loci. Our data show that over-expression of MET1, and potentially of other genes encoding epigenetic factors, offers an alternative strategy to identify epigenetic target genes and to create novel epi (show TFPI ELISA Kits)-alleles
MET1 confines ARID1 to the vegetative cell of male gametes, but ARID1 conversely represses MET1 in the central cell of female gametes.
MET1 is a thylakoid-associated TPR protein involved in photosystem II supercomplex formation and repair in Arabidopsis
Met1 gene expression throughout normal development, particularly in the flower
MET1 is a contributor to epigenetic diversity in Arabidopsis.
VIM (show VIM ELISA Kits) proteins regulate genome-wide epigenetic gene silencing through coordinated modulation of DNA methylation and histone modification status in collaboration with MET1
VIM proteins function in transcriptional regulation via their roles in the MET1 DNA methylation pathway.
Genetic studies indicate that the Polycomb Repressive Complex 2 (PRC2) but not the DNA METHYLTRANSFERASE1 (MET1) is involved in regulating imprinted expression in the embryo. [MET1]
MET1 restores body methylation, which is region-specific but random with respect to the affected CG sites, and is moderately although not decisively influenced by transcription.
There is a mechanistic link between two major epigenetic pathways involved in histone and DNA methylation in plants by physical interaction of MET1 with the FIS-PRC2 core component MEA.
We show that expression of Id-1 (show IDH1 ELISA Kits), a negative regulator of myogenesis, is enhanced in Dnmt1-deficient cultures, leading to enhanced transdifferentiation of myoblasts toward the osteogenic lineage. Thus, these studies demonstrate that Dnmt1 influences cellular identity and determines lineage fidelity.
this study shows that DNMT1 might directly repress p53 (show TP53 ELISA Kits), at least in part, by binding to the p53 (show TP53 ELISA Kits) promoter locus
Knockdown of DNMT3A or DNMT1 protected neurons against mutant Htt-induced toxicity, together demonstrating a requirement for DNMTs in mutant Htt-triggered neuronal death and suggesting a neurodegenerative mechanism based on DNA methylation-mediated transcriptional repression.
Sp1 (show SP1 ELISA Kits)/NFkappaB p65 (show NFkBP65 ELISA Kits)-Dnmt1 pathway may be exploited as a therapeutic target for protecting against podocyte injury in diabetic nephropathy.
2-hydroxyglutarate bound to DNMT1 and stimulated its association with the RIP3 promoter, inducing hypermethylation that reduces RIP3 protein and consequently impaired RIP3-dependent necroptosis.
The results demonstrated that Islet1 (show ISL1 ELISA Kits) upregulated expression of general control of amino acid biosynthesis protein 5 (show CAPS ELISA Kits) (Gcn5) and enhanced the binding of Gcn5 to the promoters of GATA binding protein 4 (GATA4 (show GATA4 ELISA Kits)) and NK2 homeobox 5 (Nkx2.5 (show NKX2-5 ELISA Kits)). In addition, Islet-1 (show ISL1 ELISA Kits) downregulated DNA methyltransferase (DNMT)1 expression and reduced its binding to the GATA4 (show GATA4 ELISA Kits) promoter.
Data show that RGS6 (show RGS6 ELISA Kits) loss impairs p53 (show TP53 ELISA Kits) activation and promotes aberrant accumulation of oncogenic protein DNMT1 in urothelium.
Data (including data from studies using knockout/transgenic mice) suggest that neuronal Dnmt1 regulates energy homeostasis through pathways controlling energy homeostasis; here, neuronal Dnmt1 deficiency prevents diet-induced obesity, reduces adiposity, reduces food intake, and increases energy expenditure in male mice.
Deletion of DNmt1 in postnatal forebrain neurons results in anxiolytic and antidepressant-like responses.
Upon lysolecithin injection in the spinal cord of transgenic mice, study detected defective oligodendrocyte progenitor cells differentiation and inefficient remyelination in the DNA methyltransferase 3a (show DNMT3A ELISA Kits) null and DNA methyltransferase 1/DNA methyltransferase 3a (show DNMT3A ELISA Kits) null mice.
DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene.
DNA (cytosine-5)-methyltransferase 1
, CXXC-type zinc finger protein 9
, DNA MTase HsaI
, DNA methyltransferase HsaI
, DNA methyltransferase 1
, DNA (cytosine 5 ) methyltransferase 1
, DNA methyltransferase (cytosine 5 ) methyltransferase
, DNA methyltransferase b
, DNA MTase RnoIP
, DNA methyltransferase (cytosine-5) 1
, DNA methyltransferase I
, DNA MTase GgaI
, DNA MeTase
, DNA methyltransferase GgaI
, DNA MTase MmuI
, DNA methyltransferase MmuI