anti-DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1) Antibodies

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Additionally we are shipping DNA (Cytosine-5-)-Methyltransferase 3 Like Proteins (12) and DNA (Cytosine-5-)-Methyltransferase 3 Like Kits (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TRDMT1 54427 Q9CWR8
TRDMT1 29947 Q9UJW3
TRDMT1 309680 Q1LZ50
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Top anti-DNA (Cytosine-5-)-Methyltransferase 3 Like Antibodies at antibodies-online.com

Showing 10 out of 201 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated AA, ICC, IF, IHC, IP, WB SMC 341DNMT3LRat Tissue Mix Western Blotting. 100 μg Log in to see 3 to 4 Days
$453.70
Details
Human Rabbit Un-conjugated ChIP, ELISA, ICC, IF, IHC, IP, WB Western blot analysis of Hela whole cell lysates, using DNMT3L Antibody. The lane on the left is treated with the antigen-specific peptide. ABIN6277187 at 1/100 staining Mouse testis tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$484.00
Details
Human Mouse FITC AA, ICC, IF, IHC, IP, WB Immunohistochemistry analysis using Mouse Anti-Dnmt3L Monoclonal Antibody, Clone S117-9 . Tissue: backskin. Species: Mouse. Fixation: Bouin's Fixative and paraffin-embedded. Primary Antibody: Mouse Anti-Dnmt3L Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Lower layers of the epidermis have positive cell staining in the cytoplasm. Western Blot analysis of Human tissue lysate showing detection of Dnmt3L protein using Mouse Anti-Dnmt3L Monoclonal Antibody, Clone S117-9 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Dnmt3L Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Log in to see 3 to 4 Days
$504.40
Details
Human Mouse APC AA, ICC, IF, IHC, IP, WB Immunohistochemistry analysis using Mouse Anti-Dnmt3L Monoclonal Antibody, Clone S117-9 . Tissue: backskin. Species: Mouse. Fixation: Bouin's Fixative and paraffin-embedded. Primary Antibody: Mouse Anti-Dnmt3L Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Lower layers of the epidermis have positive cell staining in the cytoplasm. Western Blot analysis of Human tissue lysate showing detection of Dnmt3L protein using Mouse Anti-Dnmt3L Monoclonal Antibody, Clone S117-9 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Dnmt3L Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Log in to see 3 to 4 Days
$513.50
Details
Human Mouse PerCP AA, ICC, IF, IHC, IP, WB Immunohistochemistry analysis using Mouse Anti-Dnmt3L Monoclonal Antibody, Clone S117-9 . Tissue: backskin. Species: Mouse. Fixation: Bouin's Fixative and paraffin-embedded. Primary Antibody: Mouse Anti-Dnmt3L Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Lower layers of the epidermis have positive cell staining in the cytoplasm. Western Blot analysis of Human tissue lysate showing detection of Dnmt3L protein using Mouse Anti-Dnmt3L Monoclonal Antibody, Clone S117-9 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Dnmt3L Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Log in to see 3 to 4 Days
$513.50
Details
Human Mouse Atto 488 AA, ICC, IF, IHC, IP, WB Immunohistochemistry analysis using Mouse Anti-Dnmt3L Monoclonal Antibody, Clone S117-9 . Tissue: backskin. Species: Mouse. Fixation: Bouin's Fixative and paraffin-embedded. Primary Antibody: Mouse Anti-Dnmt3L Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Lower layers of the epidermis have positive cell staining in the cytoplasm. Western Blot analysis of Human tissue lysate showing detection of Dnmt3L protein using Mouse Anti-Dnmt3L Monoclonal Antibody, Clone S117-9 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Dnmt3L Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Log in to see 3 to 4 Days
$514.80
Details
Human Mouse Atto 565 AA, ICC, IF, IHC, IP, WB Immunohistochemistry analysis using Mouse Anti-Dnmt3L Monoclonal Antibody, Clone S117-9 . Tissue: backskin. Species: Mouse. Fixation: Bouin's Fixative and paraffin-embedded. Primary Antibody: Mouse Anti-Dnmt3L Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Lower layers of the epidermis have positive cell staining in the cytoplasm. Western Blot analysis of Human tissue lysate showing detection of Dnmt3L protein using Mouse Anti-Dnmt3L Monoclonal Antibody, Clone S117-9 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Dnmt3L Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Log in to see 3 to 4 Days
$514.80
Details
Human Mouse Atto 594 AA, ICC, IF, IHC, IP, WB Immunohistochemistry analysis using Mouse Anti-Dnmt3L Monoclonal Antibody, Clone S117-9 . Tissue: backskin. Species: Mouse. Fixation: Bouin's Fixative and paraffin-embedded. Primary Antibody: Mouse Anti-Dnmt3L Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Lower layers of the epidermis have positive cell staining in the cytoplasm. Western Blot analysis of Human tissue lysate showing detection of Dnmt3L protein using Mouse Anti-Dnmt3L Monoclonal Antibody, Clone S117-9 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Dnmt3L Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Log in to see 3 to 4 Days
$514.80
Details
Human Mouse Atto 633 AA, ICC, IF, IHC, IP, WB Immunohistochemistry analysis using Mouse Anti-Dnmt3L Monoclonal Antibody, Clone S117-9 . Tissue: backskin. Species: Mouse. Fixation: Bouin's Fixative and paraffin-embedded. Primary Antibody: Mouse Anti-Dnmt3L Monoclonal Antibody  at 1:100 for 1 hour at RT. Secondary Antibody: FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Lower layers of the epidermis have positive cell staining in the cytoplasm. Western Blot analysis of Human tissue lysate showing detection of Dnmt3L protein using Mouse Anti-Dnmt3L Monoclonal Antibody, Clone S117-9 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Dnmt3L Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Log in to see 3 to 4 Days
$514.80
Details

Top referenced anti-DNA (Cytosine-5-)-Methyltransferase 3 Like Antibodies

  1. Mouse (Murine) Polyclonal TRDMT1 Primary Antibody for ELISA - ABIN543192 : Aapola, Lyle, Krohn, Antonarakis, Peterson: Isolation and initial characterization of the mouse Dnmt3l gene. in Cytogenetics and cell genetics 2001 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal TRDMT1 Primary Antibody for IHC (p), ELISA - ABIN543180 : Deplus, Brenner, Burgers, Putmans, Kouzarides, de Launoit, Fuks: Dnmt3L is a transcriptional repressor that recruits histone deacetylase. in Nucleic acids research 2002 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal TRDMT1 Primary Antibody for IHC (p), WB - ABIN387892 : Chedin, Lieber, Hsieh: The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3a. in Proceedings of the National Academy of Sciences of the United States of America 2002 (PubMed)
    Show all 3 Pubmed References

  4. Human Polyclonal TRDMT1 Primary Antibody for IHC (p), WB - ABIN4305755 : Bonnin, Belville, Chiambaretta, Sapin, Blanchon: DNA methyl transferases are differentially expressed in the human anterior eye segment. in Acta ophthalmologica 2014 (PubMed)

  5. Human Polyclonal TRDMT1 Primary Antibody for WB - ABIN2668677 : Ajj, Chesnel, Pinel, Plenat, Flament, Dumond: An alkylphenol mix promotes seminoma derived cell proliferation through an ERalpha36-mediated mechanism. in PLoS ONE 2013 (PubMed)

  6. Mammalian Monoclonal TRDMT1 Primary Antibody for ISt, IHC - ABIN1304620 : Satterlee, Beckel-Mitchener, McAllister, Procaccini, Rutter, Tyson, Chadwick: Community resources and technologies developed through the NIH Roadmap Epigenomics Program. in Methods in molecular biology (Clifton, N.J.) 2014 (PubMed)

More Antibodies against DNA (Cytosine-5-)-Methyltransferase 3 Like Interaction Partners

Mouse (Murine) DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1) interaction partners

  1. The Sirt1 protein suppressed transcription of Dnmt3l.

  2. The Dnmt3l mutation greatly reduced DNA methylation levels at most retrotransposons, but its impact on their RNA abundance was limited in prospermatogonia. In Pld6 mutant germ cells, although only a few retrotransposons exhibited reduced DNA methylation, many showed increased expression at the RNA level.

  3. Dnmt3l-KO donor cells may offer a more permissive epigenetic state that is beneficial for Nuclear transfer reprogramming

  4. By interacting with TRIM28, DNMT3L can attract various enzymes to form a DNMT3L-induced repressive complex to remove active marks and add repressive marks to histone proteins.

  5. Hypomethylation of highly methylated CpG islands was caused by the downregulation of Dnmt3L and Dnmt3a due to hepatitis B X-protein bound to their promoters.

  6. DNMT3L is required to delicately balance the cycling and quiescence of spermatogonial progenitor cells

  7. Study demonstrates that Dnmt3L interacts with the Polycomb PRC2 complex in competition with the DNA methyltransferases Dnmt3a and Dnmt3b to maintain low methylation levels at the Histone 3 H3K27me3 regions.

  8. Data indicate that expression of Dnmt3a, Dnmt3b, Dnmt3L as well as maintenance Dnmt1o in oocytes and zygotes was not disrupted.

  9. Reduced expression of DNMT3L in male germ cells, associated with haploinsufficiency of the paternal-effect gene Dnmt3L, results in abnormal hypomethylation of prenatal germline progenitor cells.

  10. The maternal store of Dnmt3L is not involved in embryonic de novo methylation.

  11. Dnmt3l is one of the key players in de novo DNA methylation of imprinting control elements and retrotransposons, which occurs after genome-wide epigenetic erasure during germ cell development. (Review)

  12. We observe evidence for a context-dependent contribution of Dnmt3l to set and maintain CpG and non-CpG methylation at distinct classes of repetitive elements and selected single copy genes

  13. Data show in DNMT3L-deficient germ cells at 16.5 dpc, average DNA methylation levels were about 30% of wildtype levels; however, by postnatal day 6, about half of the DNMT3L deficiency-specific hypomethylated loci had acquired normal methylation levels.

  14. Reduced dosage of the modifiers of epigenetic reprogramming Dnmt1, Dnmt3L, SmcHD1 and Foxo3a has no detectable effect on mouse telomere length in vivo.

  15. show that both Dnmt3L(s) and Dnmt3L(o) produce full-length proteins but that the Dnmt3L(at) transcripts are not translated

  16. The data demonstrate previously unrecognised roles for DNMT3L in late meiosis and in the transcriptional regulation of meiotic and post-meiotic germ cells.

  17. CG dinucleotide recognized by the Dnmt3a and Dnmt3L complex are distinctive at retroelements and imprinted domains.

  18. likely to function not directly as a DNA methyltransferase but as a regulator of methylation at imprinted loci

  19. Dnmt3L is required for the establishment of methylation imprints in oocyte. Dnmt3L is required for spermatogenesis.

  20. Loss of Dnmt3L from early germ cells caused meiotic failure in spermatocytes, which do not express Dnmt3L

Human DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1) interaction partners

  1. DNMT3L overexpression is associated with Down syndrome.

  2. the present study has demonstrated that variations in the DNMT3L gene do not contribute to stage I-II endometriosis-associated infertility.

  3. DNMT3L rs2070565 (genotype P = 0.007, allele P = 0.0026) confers an increased risk of developing schizophrenia at an early age in individuals with family history.

  4. crystal structures of DNMT3A-DNMT3L (autoinhibitory form) and DNMT3A-DNMT3L-H3 (active form) complexes at 3.82 and 2.90 A resolution, respectively

  5. DNMT3L can address DNMT3A/B to specific sites by directly interacting with TFs that do not directly interact with DNMT3A/B

  6. CpG island encompassing the promoter and first exon of human DNMT3L gene is a PcG/TrX response element

  7. DNMT3L is one of the key players in de novo DNA methylation of imprinting control elements and retrotransposons, which occurs after genome-wide epigenetic erasure during germ cell development. (Review)

  8. SNP rs2070565, as well as haplotypes AAA and GAA, may be associated with male infertility; DNMT3L may contribute to azoospermia susceptibility in humans

  9. Genetic polymorphisms of DNMT3L involved in hypermethylation of chromosomal ends are associated with greater risk of developing ovarian endometriosis.

  10. mutation analysis of SYCP3, DNMT3L and MSH4 in patients with maturation arrest of spermatogenesis and couples with recurrent miscarriages.

  11. This study offers insights into the manner by which DNA methylation patterns are deposited and reveals a new level of interplay between members of the de novo DNMT family.

  12. Processive methylation is enhanced 3-fold in the presence of DNMT3L, an inactive homolog of DNMT3A, therefore providing a mechanism for the previously described DNMT3L activation of DNMT3A.

  13. We have identified loss of methylation at the DNMT3L promoter in ocular surface squamous neoplasia cases.

  14. DNMT3L is a novel marker and is essential for the growth of human embryonal carcinoma.

  15. DNMT3L exerts a major effect on the transcriptional regulation of a specific target gene, such as thymine DNA glycosylase

  16. CG dinucleotide recognized by the Dnmt3a and Dnmt3L complex are distinctive at retroelements and imprinted domains.

  17. DNMT3L stimulates de novo methylation by Dnmt3a.

  18. The carboxyl-terminal half of DNMT3L was found to be responsible for the stimulation of the DNA methylation activity of Dnmt3a and Dnmt3b.

  19. Regulates germ cell-specific gene expression and intracisternal A-particle suppression, which are critical for male germ cell proliferation and meiosis.

  20. Dnmt3L-Dnmt3b interactions play an important role in the regulation of DNA methylation during mammalian development.

DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1) Antigen Profile

Protein Summary

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with TRDMT1

  • DNA methyltransferase 3 like (DNMT3L) antibody
  • DNA (cytosine-5-)-methyltransferase 3-like (Dnmt3l) antibody
  • DNA methyltransferase 3 like (Dnmt3l) antibody
  • D6Ertd14e antibody
  • DNMT3L antibody
  • ecat7 antibody

Protein level used designations for TRDMT1

DNA (cytosine-5-)-methyltransferase 3-like , cytosine-5-methyltransferase 3-like protein , DNA (cytosine-5)-methyltransferase 3-like , human cytosine-5-methyltransferase 3-like protein

GENE ID SPECIES
100050680 Equus caballus
470099 Pan troglodytes
613785 Bos taurus
608536 Canis lupus familiaris
54427 Mus musculus
29947 Homo sapiens
309680 Rattus norvegicus
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